Požymis
Mental deterioration
Loss of previously present mental abilities, generally in adults.
Santrauka
- Taip pat vadinama
- Cognitive decline, Cognitive decline, progressive, Intellectual deterioration, Progressive cognitive decline
- Kūno sistema
- Abnormality of the nervous system
Atskaitos genomasGRCh38hg38
Pozicijos genų ir variantų puslapiuose rodomos pagal šį pasirinkimą šioje naršyklėje.
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Įsigyti savo Genome Test189 genų susiję su Mental deterioration
Šių genų pakitimai sukelia retas ligas, kuriose pasireiškia Mental deterioration. Dauguma žmonių, turinčių šį požymį, neturi nė vienos iš tų ligų, o šiame sąraše esantis genas nieko nesako apie kieno nors paties genomą.
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| AARS1alanyl-tRNA synthetase 1 | Visada | 2 ligose |
| ARHGEF15Rho guanine nucleotide exchange factor 15 | Visada | 1 ligoje |
| ATP13A2ATPase cation transporting 13A2 | Visada | 2 ligose |
| CARS2cysteinyl-tRNA synthetase 2, mitochondrial | Visada | 1 ligoje |
| CLN6CLN6 transmembrane ER protein | Visada | 1 ligoje |
| COX6B1cytochrome c oxidase subunit 6B1 | Visada | 1 ligoje |
| CTSAcathepsin A | Visada | 1 ligoje |
| CTSDcathepsin D | Visada | 1 ligoje |
| CTSFcathepsin F | Visada | 1 ligoje |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Visada | 1 ligoje |
| FMR1fragile X messenger ribonucleoprotein 1 | Visada | 1 ligoje |
| FUCA1alpha-L-fucosidase 1 | Visada | 1 ligoje |
| KARS1lysyl-tRNA synthetase 1 | Visada | 1 ligoje |
| PLA2G6phospholipase A2 group VI | Visada | 3 ligose |
| PLP1proteolipid protein 1 | Visada | 2 ligose |
| POLR3KRNA polymerase III subunit K | Visada | 1 ligoje |
| RPS6KC1ribosomal protein S6 kinase C1 | Visada | 1 ligoje |
| STUB1STIP1 homology and U-box containing protein 1 | Visada | 1 ligoje |
| TSPOAP1TSPO associated protein 1 | Visada | 2 ligose |
| VPS13Cvacuolar protein sorting 13 homolog C | Visada | 1 ligoje |
| WDR45WD repeat domain 45 | Visada | 1 ligoje |
| XPAXPA, DNA damage recognition and repair factor | Visada | 1 ligoje |
| ABCD1ATP binding cassette subfamily D member 1 | Labai dažnai (80–99%) | 2 ligose |
| ACTBactin beta | Labai dažnai (80–99%) | 1 ligoje |
| APPamyloid beta precursor protein | Labai dažnai (80–99%) | 2 ligose |
| CHMP2Bcharged multivesicular body protein 2B | Labai dažnai (80–99%) | 2 ligose |
| DCAF17DDB1 and CUL4 associated factor 17 | Labai dažnai (80–99%) | 1 ligoje |
| FA2Hfatty acid 2-hydroxylase | Labai dažnai (80–99%) | 3 ligose |
| GALCgalactosylceramidase | Labai dažnai (80–99%) | 3 ligose |
| GRNgranulin precursor | Labai dažnai (80–99%) | 3 ligose |
| HEPACAMhepatic and glial cell adhesion molecule | Labai dažnai (80–99%) | 2 ligose |
| HTThuntingtin | Labai dažnai (80–99%) | 1 ligoje |
| MAPTmicrotubule associated protein tau | Labai dažnai (80–99%) | 6 ligose |
| NBNnibrin | Labai dažnai (80–99%) | 1 ligoje |
| PSAPprosaposin | Labai dažnai (80–99%) | 2 ligose |
| PSEN1presenilin 1 | Labai dažnai (80–99%) | 2 ligose |
| ROGDIrogdi atypical leucine zipper | Labai dažnai (80–99%) | 1 ligoje |
| SLC13A5solute carrier family 13 member 5 | Labai dažnai (80–99%) | 2 ligose |
| SLC2A3solute carrier family 2 member 3 | Labai dažnai (80–99%) | 1 ligoje |
| SLC44A1solute carrier family 44 member 1 | Labai dažnai (80–99%) | 1 ligoje |
Rodyti dar 149 genų
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| SPG11SPG11 vesicle trafficking associated, spatacsin | Labai dažnai (80–99%) | 2 ligose |
| SQSTM1sequestosome 1 | Labai dažnai (80–99%) | 2 ligose |
| TMEM106Btransmembrane protein 106B | Labai dažnai (80–99%) | 2 ligose |
| TREM2triggering receptor expressed on myeloid cells 2 | Labai dažnai (80–99%) | 2 ligose |
| VCPvalosin containing protein | Labai dažnai (80–99%) | 2 ligose |
| ADA2adenosine deaminase 2 | Dažnai (30–79%) | 2 ligose |
| AGKacylglycerol kinase | Dažnai (30–79%) | 1 ligoje |
| AQP4aquaporin 4 | Dažnai (30–79%) | 1 ligoje |
| ATXN7ataxin 7 | Dažnai (30–79%) | 2 ligose |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Dažnai (30–79%) | 2 ligose |
| CHD2chromodomain helicase DNA binding protein 2 | Dažnai (30–79%) | 1 ligoje |
| CNTNAP2contactin associated protein 2 | Dažnai (30–79%) | 1 ligoje |
| CPLX1complexin 1 | Dažnai (30–79%) | 1 ligoje |
| CST3cystatin C | Dažnai (30–79%) | 1 ligoje |
| CSTBcystatin B | Dažnai (30–79%) | 1 ligoje |
| CUX2cut like homeobox 2 | Dažnai (30–79%) | 1 ligoje |
| DNM1dynamin 1 | Dažnai (30–79%) | 2 ligose |
| EPG5ectopic P-granules 5 autophagy tethering factor | Dažnai (30–79%) | 1 ligoje |
| EPM2AEPM2A glucan phosphatase, laforin | Dažnai (30–79%) | 1 ligoje |
| FTH1ferritin heavy chain 1 | Dažnai (30–79%) | 1 ligoje |
| GABRB3gamma-aminobutyric acid type A receptor subunit beta3 | Dažnai (30–79%) | 1 ligoje |
| GALTgalactose-1-phosphate uridylyltransferase | Dažnai (30–79%) | 1 ligoje |
| GDAP2ganglioside induced differentiation associated protein 2 | Dažnai (30–79%) | 1 ligoje |
| GOSR2golgi SNAP receptor complex member 2 | Dažnai (30–79%) | 1 ligoje |
| GPRC5BG protein-coupled receptor class C group 5 member B | Dažnai (30–79%) | 1 ligoje |
| HEXBhexosaminidase subunit beta | Dažnai (30–79%) | 1 ligoje |
| HMBShydroxymethylbilane synthase | Dažnai (30–79%) | 1 ligoje |
| JAM2junctional adhesion molecule 2 | Dažnai (30–79%) | 2 ligose |
| KCNC1potassium voltage-gated channel subfamily C member 1 | Dažnai (30–79%) | 1 ligoje |
| MAPK10mitogen-activated protein kinase 10 | Dažnai (30–79%) | 1 ligoje |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Dažnai (30–79%) | 1 ligoje |
| MLC1modulator of VRAC current 1 | Dažnai (30–79%) | 1 ligoje |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Dažnai (30–79%) | 1 ligoje |
| MTHFRmethylenetetrahydrofolate reductase | Dažnai (30–79%) | 1 ligoje |
| NHLRC1NHL repeat containing E3 ubiquitin protein ligase 1 | Dažnai (30–79%) | 1 ligoje |
| PANK2pantothenate kinase 2 | Dažnai (30–79%) | 1 ligoje |
| PRNPprion protein (Kanno blood group) | Dažnai (30–79%) | 2 ligose |
| RRP12ribosomal RNA processing 12 homolog | Dažnai (30–79%) | 1 ligoje |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Dažnai (30–79%) | 3 ligose |
| SCN8Asodium voltage-gated channel alpha subunit 8 | Dažnai (30–79%) | 2 ligose |
| SLC7A6OSsolute carrier family 7 member 6 opposite strand | Dažnai (30–79%) | 1 ligoje |
| SLC9A6solute carrier family 9 member A6 | Dažnai (30–79%) | 1 ligoje |
| SMPD1sphingomyelin phosphodiesterase 1 | Dažnai (30–79%) | 1 ligoje |
| SNORD118small nucleolar RNA, C/D box 118 | Dažnai (30–79%) | 2 ligose |
| SPG21SPG21 abhydrolase domain containing, maspardin | Dažnai (30–79%) | 1 ligoje |
| SYNJ1synaptojanin 1 | Dažnai (30–79%) | 2 ligose |
| TBC1D24TBC1 domain family member 24 | Dažnai (30–79%) | 1 ligoje |
| TBPTATA-box binding protein | Dažnai (30–79%) | 1 ligoje |
| TIMM8Atranslocase of inner mitochondrial membrane 8A | Dažnai (30–79%) | 2 ligose |
| TMEM240transmembrane protein 240 | Dažnai (30–79%) | 1 ligoje |
| AASSaminoadipate-semialdehyde synthase | Kartais (5–29%) | 1 ligoje |
| ACTL6Bactin like 6B | Kartais (5–29%) | 1 ligoje |
| AMACRalpha-methylacyl-CoA racemase | Kartais (5–29%) | 1 ligoje |
| AP3B2adaptor related protein complex 3 subunit beta 2 | Kartais (5–29%) | 1 ligoje |
| APTXaprataxin | Kartais (5–29%) | 1 ligoje |
| ASAH1N-acylsphingosine amidohydrolase 1 | Kartais (5–29%) | 1 ligoje |
| ATP1A2ATPase Na+/K+ transporting subunit alpha 2 | Kartais (5–29%) | 1 ligoje |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Kartais (5–29%) | 2 ligose |
| ATP6V1AATPase H+ transporting V1 subunit A | Kartais (5–29%) | 1 ligoje |
| CACNA1Bcalcium voltage-gated channel subunit alpha1 B | Kartais (5–29%) | 1 ligoje |
| CACNA2D1calcium voltage-gated channel auxiliary subunit alpha2delta 1 | Kartais (5–29%) | 1 ligoje |
| CDK19cyclin dependent kinase 19 | Kartais (5–29%) | 1 ligoje |
| CELF2CUGBP Elav-like family member 2 | Kartais (5–29%) | 1 ligoje |
| CLTCclathrin heavy chain | Kartais (5–29%) | 1 ligoje |
| CNKSR2connector enhancer of kinase suppressor of Ras 2 | Kartais (5–29%) | 1 ligoje |
| CYFIP2cytoplasmic FMR1 interacting protein 2 | Kartais (5–29%) | 1 ligoje |
| DALRD3DALR anticodon binding domain containing 3 | Kartais (5–29%) | 1 ligoje |
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Kartais (5–29%) | 1 ligoje |
| DEPDC5DEP domain containing 5, GATOR1 subcomplex subunit | Kartais (5–29%) | 1 ligoje |
| DHDDSdehydrodolichyl diphosphate synthase subunit | Kartais (5–29%) | 1 ligoje |
| DNAJC13DnaJ heat shock protein family (Hsp40) member C13 | Kartais (5–29%) | 1 ligoje |
| DNMT1DNA methyltransferase 1 | Kartais (5–29%) | 1 ligoje |
| EEF1A2eukaryotic translation elongation factor 1 alpha 2 | Kartais (5–29%) | 1 ligoje |
| EIF4G1eukaryotic translation initiation factor 4 gamma 1 | Kartais (5–29%) | 1 ligoje |
| FBXO28F-box protein 28 | Kartais (5–29%) | 1 ligoje |
| FGF12fibroblast growth factor 12 | Kartais (5–29%) | 1 ligoje |
| FOXG1forkhead box G1 | Kartais (5–29%) | 1 ligoje |
| FZR1fizzy and cell division cycle 20 related 1 | Kartais (5–29%) | 1 ligoje |
| GABBR2gamma-aminobutyric acid type B receptor subunit 2 | Kartais (5–29%) | 1 ligoje |
| GABRA2gamma-aminobutyric acid type A receptor subunit alpha2 | Kartais (5–29%) | 1 ligoje |
| GABRA5gamma-aminobutyric acid type A receptor subunit alpha5 | Kartais (5–29%) | 1 ligoje |
| GABRB2gamma-aminobutyric acid type A receptor subunit beta2 | Kartais (5–29%) | 1 ligoje |
| GABRG2gamma-aminobutyric acid type A receptor subunit gamma2 | Kartais (5–29%) | 1 ligoje |
| GBA1glucosylceramidase beta 1 | Kartais (5–29%) | 1 ligoje |
| GIGYF2GRB10 interacting GYF protein 2 | Kartais (5–29%) | 1 ligoje |
| GRIN2Dglutamate ionotropic receptor NMDA type subunit 2D | Kartais (5–29%) | 1 ligoje |
| HCN1hyperpolarization activated cyclic nucleotide gated potassium channel 1 | Kartais (5–29%) | 1 ligoje |
| HTRA1HtrA serine peptidase 1 | Kartais (5–29%) | 2 ligose |
| KCNA2potassium voltage-gated channel subfamily A member 2 | Kartais (5–29%) | 1 ligoje |
| KCNB1potassium voltage-gated channel subfamily B member 1 | Kartais (5–29%) | 1 ligoje |
| KCNC2potassium voltage-gated channel subfamily C member 2 | Kartais (5–29%) | 1 ligoje |
| KCNH5potassium voltage-gated channel subfamily H member 5 | Kartais (5–29%) | 1 ligoje |
| L1CAML1 cell adhesion molecule | Kartais (5–29%) | 1 ligoje |
| LIG3DNA ligase 3 | Kartais (5–29%) | 1 ligoje |
| LRRK2leucine rich repeat kinase 2 | Kartais (5–29%) | 1 ligoje |
| MAP2K1mitogen-activated protein kinase kinase 1 | Kartais (5–29%) | 1 ligoje |
| MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2 | Kartais (5–29%) | 1 ligoje |
| MFN2mitofusin 2 | Kartais (5–29%) | 1 ligoje |
| MMACHCmetabolism of cobalamin associated C | Kartais (5–29%) | 1 ligoje |
| MYORGmyogenesis regulating glycosidase | Kartais (5–29%) | 2 ligose |
| NECAP1NECAP endocytosis associated 1 | Kartais (5–29%) | 1 ligoje |
| NRASNRAS proto-oncogene, GTPase | Kartais (5–29%) | 2 ligose |
| NTRK2neurotrophic receptor tyrosine kinase 2 | Kartais (5–29%) | 1 ligoje |
| NUS1NUS1 dehydrodolichyl diphosphate synthase subunit | Kartais (5–29%) | 1 ligoje |
| PACS2phosphofurin acidic cluster sorting protein 2 | Kartais (5–29%) | 1 ligoje |
| PARS2prolyl-tRNA synthetase 2, mitochondrial | Kartais (5–29%) | 1 ligoje |
| PPP3CAprotein phosphatase 3 catalytic subunit alpha | Kartais (5–29%) | 1 ligoje |
| PRDM8PR/SET domain 8 | Kartais (5–29%) | 1 ligoje |
| SCN3Asodium voltage-gated channel alpha subunit 3 | Kartais (5–29%) | 1 ligoje |
| SLC1A2solute carrier family 1 member 2 | Kartais (5–29%) | 1 ligoje |
| SLC38A3solute carrier family 38 member 3 | Kartais (5–29%) | 1 ligoje |
| SNCAsynuclein alpha | Kartais (5–29%) | 2 ligose |
| SYNGAP1synaptic Ras GTPase activating protein 1 | Kartais (5–29%) | 1 ligoje |
| SZT2SZT2 subunit of KICSTOR complex | Kartais (5–29%) | 1 ligoje |
| TRAK1trafficking kinesin protein 1 | Kartais (5–29%) | 1 ligoje |
| TTPAalpha tocopherol transfer protein | Kartais (5–29%) | 1 ligoje |
| UBA5ubiquitin like modifier activating enzyme 5 | Kartais (5–29%) | 1 ligoje |
| UBAP1ubiquitin associated protein 1 | Kartais (5–29%) | 1 ligoje |
| UFSP2UFM1 specific peptidase 2 | Kartais (5–29%) | 1 ligoje |
| VPS13Avacuolar protein sorting 13 homolog A | Kartais (5–29%) | 1 ligoje |
| VPS35VPS35 retromer complex component | Kartais (5–29%) | 1 ligoje |
| YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma | Kartais (5–29%) | 1 ligoje |
| KCNQ2potassium voltage-gated channel subfamily Q member 2 | Retai (1–4 %) | 1 ligoje |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Retai (1–4 %) | 1 ligoje |
| TLR3toll like receptor 3 | Retai (1–4 %) | 1 ligoje |
| AP5Z1adaptor related protein complex 5 subunit zeta 1 | Neužfiksuota | 1 ligoje |
| ARSAarylsulfatase A | Neužfiksuota | 1 ligoje |
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Neužfiksuota | 1 ligoje |
| C19orf12chromosome 19 open reading frame 12 | Neužfiksuota | 1 ligoje |
| CLN8CLN8 transmembrane ER and ERGIC protein | Neužfiksuota | 1 ligoje |
| COASYCoenzyme A synthase | Neužfiksuota | 1 ligoje |
| CSF1Rcolony stimulating factor 1 receptor | Neužfiksuota | 2 ligose |
| CTC1CST telomere replication complex component 1 | Neužfiksuota | 1 ligoje |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Neužfiksuota | 1 ligoje |
| GBA2glucosylceramidase beta 2 | Neužfiksuota | 1 ligoje |
| GNASGNAS complex locus | Neužfiksuota | 1 ligoje |
| MFSD8major facilitator superfamily domain containing 8 | Neužfiksuota | 1 ligoje |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Neužfiksuota | 1 ligoje |
| PDE10Aphosphodiesterase 10A | Neužfiksuota | 1 ligoje |
| PDE11Aphosphodiesterase 11A | Neužfiksuota | 1 ligoje |
| PDGFBplatelet derived growth factor subunit B | Neužfiksuota | 1 ligoje |
| PDGFRBplatelet derived growth factor receptor beta | Neužfiksuota | 1 ligoje |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Neužfiksuota | 1 ligoje |
| PRKCGprotein kinase C gamma | Neužfiksuota | 1 ligoje |
| SGPL1sphingosine-1-phosphate lyase 1 | Neužfiksuota | 1 ligoje |
| SLC20A2solute carrier family 20 member 2 | Neužfiksuota | 1 ligoje |
| TBK1TANK binding kinase 1 | Neužfiksuota | 1 ligoje |
| UBTFupstream binding transcription factor | Neužfiksuota | 1 ligoje |
| XPR1xenotropic and polytropic retrovirus receptor 1 | Neužfiksuota | 1 ligoje |
Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.
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- Žmogaus fenotipo ontologija, 2026-09-01 leidimas: požymis, jo pavadinimai, apibrėžimas ir su juo susiję genai. Daugiau sužinokite svetainėje hpo.jax.org.
- Duomenų leidimas 2026.10.16-c6eea6bf.
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