Požymis
Dementia
A loss of global cognitive ability of sufficient amount to interfere with normal social or occupational function. Dementia represents a loss of previously present cognitive abilities, generally in adults, and can affect memory, thinking, language, judgment, and behavior.
Santrauka
- Taip pat vadinama
- Dementia, progressive, Progressive dementia
- Kūno sistema
- Abnormality of the nervous system
Atskaitos genomasGRCh38hg38
Pozicijos genų ir variantų puslapiuose rodomos pagal šį pasirinkimą šioje naršyklėje.
Read the genes linked to Dementia, and the rest of your genome, with one test.
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Įsigyti savo Genome Test195 genų susiję su Dementia
Šių genų pakitimai sukelia retas ligas, kuriose pasireiškia Dementia. Dauguma žmonių, turinčių šį požymį, neturi nė vienos iš tų ligų, o šiame sąraše esantis genas nieko nesako apie kieno nors paties genomą.
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| AARS1alanyl-tRNA synthetase 1 | Visada | 1 ligoje |
| ABCB7ATP binding cassette subfamily B member 7 | Visada | 1 ligoje |
| ATP13A2ATPase cation transporting 13A2 | Visada | 4 ligose |
| CERS1ceramide synthase 1 | Visada | 1 ligoje |
| CTSFcathepsin F | Visada | 1 ligoje |
| CYLDCYLD lysine 63 deubiquitinase | Visada | 1 ligoje |
| DNAJC5DnaJ heat shock protein family (Hsp40) member C5 | Visada | 1 ligoje |
| GBA2glucosylceramidase beta 2 | Visada | 2 ligose |
| GPRC5BG protein-coupled receptor class C group 5 member B | Visada | 1 ligoje |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Visada | 1 ligoje |
| PRNPprion protein (Kanno blood group) | Visada | 9 ligose |
| SPG21SPG21 abhydrolase domain containing, maspardin | Visada | 2 ligose |
| TBPTATA-box binding protein | Visada | 2 ligose |
| TREM2triggering receptor expressed on myeloid cells 2 | Visada | 5 ligose |
| TYROBPtransmembrane immune signaling adaptor TYROBP | Visada | 1 ligoje |
| VPS13Cvacuolar protein sorting 13 homolog C | Visada | 2 ligose |
| WDR45WD repeat domain 45 | Visada | 2 ligose |
| APPamyloid beta precursor protein | Labai dažnai (80–99%) | 7 ligose |
| ATP6V0A2ATPase H+ transporting V0 subunit a2 | Labai dažnai (80–99%) | 1 ligoje |
| ATP6V1AATPase H+ transporting V1 subunit A | Labai dažnai (80–99%) | 1 ligoje |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Labai dažnai (80–99%) | 1 ligoje |
| FMR1fragile X messenger ribonucleoprotein 1 | Labai dažnai (80–99%) | 2 ligose |
| HTRA1HtrA serine peptidase 1 | Labai dažnai (80–99%) | 3 ligose |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Labai dažnai (80–99%) | 2 ligose |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Labai dažnai (80–99%) | 2 ligose |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Labai dažnai (80–99%) | 2 ligose |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Labai dažnai (80–99%) | 2 ligose |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Labai dažnai (80–99%) | 1 ligoje |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Labai dažnai (80–99%) | 2 ligose |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Labai dažnai (80–99%) | 2 ligose |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Labai dažnai (80–99%) | 2 ligose |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Labai dažnai (80–99%) | 2 ligose |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Labai dažnai (80–99%) | 3 ligose |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Labai dažnai (80–99%) | 2 ligose |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Labai dažnai (80–99%) | 2 ligose |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Labai dažnai (80–99%) | 2 ligose |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Labai dažnai (80–99%) | 2 ligose |
| PSEN1presenilin 1 | Labai dažnai (80–99%) | 4 ligose |
| PSEN2presenilin 2 | Labai dažnai (80–99%) | 3 ligose |
| ROGDIrogdi atypical leucine zipper | Labai dažnai (80–99%) | 2 ligose |
Rodyti dar 155 genų
| Genas | Kaip dažnai pasireiškia | Ligos |
|---|---|---|
| SLC13A5solute carrier family 13 member 5 | Labai dažnai (80–99%) | 1 ligoje |
| SORL1sortilin related receptor 1 | Labai dažnai (80–99%) | 1 ligoje |
| TOMM40translocase of outer mitochondrial membrane 40 | Labai dažnai (80–99%) | 1 ligoje |
| WFS1wolframin ER transmembrane glycoprotein | Labai dažnai (80–99%) | 2 ligose |
| ADA2adenosine deaminase 2 | Dažnai (30–79%) | 1 ligoje |
| APOEapolipoprotein E | Dažnai (30–79%) | 3 ligose |
| ARSAarylsulfatase A | Dažnai (30–79%) | 1 ligoje |
| ATN1atrophin 1 | Dažnai (30–79%) | 2 ligose |
| ATXN2ataxin 2 | Dažnai (30–79%) | 3 ligose |
| CBLIFcobalamin binding intrinsic factor | Dažnai (30–79%) | 1 ligoje |
| CHMP2Bcharged multivesicular body protein 2B | Dažnai (30–79%) | 1 ligoje |
| CLN6CLN6 transmembrane ER protein | Dažnai (30–79%) | 1 ligoje |
| CMPK2cytidine/uridine monophosphate kinase 2 | Dažnai (30–79%) | 1 ligoje |
| CSTBcystatin B | Dažnai (30–79%) | 2 ligose |
| DNMT1DNA methyltransferase 1 | Dažnai (30–79%) | 2 ligose |
| EPG5ectopic P-granules 5 autophagy tethering factor | Dažnai (30–79%) | 1 ligoje |
| EPM2AEPM2A glucan phosphatase, laforin | Dažnai (30–79%) | 2 ligose |
| GBA1glucosylceramidase beta 1 | Dažnai (30–79%) | 5 ligose |
| GRNgranulin precursor | Dažnai (30–79%) | 1 ligoje |
| HTThuntingtin | Dažnai (30–79%) | 2 ligose |
| JAM2junctional adhesion molecule 2 | Dažnai (30–79%) | 1 ligoje |
| MAPTmicrotubule associated protein tau | Dažnai (30–79%) | 5 ligose |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Dažnai (30–79%) | 1 ligoje |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Dažnai (30–79%) | 2 ligose |
| MYORGmyogenesis regulating glycosidase | Dažnai (30–79%) | 1 ligoje |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Dažnai (30–79%) | 1 ligoje |
| NDUFA1NADH:ubiquinone oxidoreductase subunit A1 | Dažnai (30–79%) | 1 ligoje |
| NHLRC1NHL repeat containing E3 ubiquitin protein ligase 1 | Dažnai (30–79%) | 2 ligose |
| NOTCH2NLCnotch 2 N-terminal like C | Dažnai (30–79%) | 2 ligose |
| NOTCH3notch receptor 3 | Dažnai (30–79%) | 2 ligose |
| PANK2pantothenate kinase 2 | Dažnai (30–79%) | 1 ligoje |
| PDGFBplatelet derived growth factor subunit B | Dažnai (30–79%) | 2 ligose |
| PDGFRBplatelet derived growth factor receptor beta | Dažnai (30–79%) | 2 ligose |
| PSAPprosaposin | Dažnai (30–79%) | 1 ligoje |
| RNF216ring finger protein 216 | Dažnai (30–79%) | 2 ligose |
| RRP12ribosomal RNA processing 12 homolog | Dažnai (30–79%) | 1 ligoje |
| SLC20A2solute carrier family 20 member 2 | Dažnai (30–79%) | 1 ligoje |
| TMEM106Btransmembrane protein 106B | Dažnai (30–79%) | 1 ligoje |
| TREX1three prime repair exonuclease 1 | Dažnai (30–79%) | 1 ligoje |
| TRPM7transient receptor potential cation channel subfamily M member 7 | Dažnai (30–79%) | 1 ligoje |
| VCPvalosin containing protein | Dažnai (30–79%) | 2 ligose |
| XPR1xenotropic and polytropic retrovirus receptor 1 | Dažnai (30–79%) | 2 ligose |
| AARS2alanyl-tRNA synthetase 2, mitochondrial | Kartais (5–29%) | 1 ligoje |
| ALDH18A1aldehyde dehydrogenase 18 family member A1 | Kartais (5–29%) | 2 ligose |
| AUHAU RNA binding methylglutaconyl-CoA hydratase | Kartais (5–29%) | 1 ligoje |
| CISD2CDGSH iron sulfur domain 2 | Kartais (5–29%) | 1 ligoje |
| CLN8CLN8 transmembrane ER and ERGIC protein | Kartais (5–29%) | 1 ligoje |
| COL4A1collagen type IV alpha 1 chain | Kartais (5–29%) | 1 ligoje |
| DCTN1dynactin subunit 1 | Kartais (5–29%) | 1 ligoje |
| DGUOKdeoxyguanosine kinase | Kartais (5–29%) | 2 ligose |
| DLATdihydrolipoamide S-acetyltransferase | Kartais (5–29%) | 1 ligoje |
| DNAJC6DnaJ heat shock protein family (Hsp40) member C6 | Kartais (5–29%) | 1 ligoje |
| ERCC4ERCC excision repair 4, endonuclease catalytic subunit | Kartais (5–29%) | 1 ligoje |
| FBXO7F-box protein 7 | Kartais (5–29%) | 1 ligoje |
| GALCgalactosylceramidase | Kartais (5–29%) | 1 ligoje |
| GBE11,4-alpha-glucan branching enzyme 1 | Kartais (5–29%) | 1 ligoje |
| GCDHglutaryl-CoA dehydrogenase | Kartais (5–29%) | 1 ligoje |
| HTRA2HtrA serine peptidase 2 | Kartais (5–29%) | 1 ligoje |
| JPH3junctophilin 3 | Kartais (5–29%) | 2 ligose |
| KCTD7potassium channel tetramerization domain containing 7 | Kartais (5–29%) | 1 ligoje |
| LRRK2leucine rich repeat kinase 2 | Kartais (5–29%) | 3 ligose |
| LYSTlysosomal trafficking regulator | Kartais (5–29%) | 1 ligoje |
| MATR3matrin 3 | Kartais (5–29%) | 2 ligose |
| MT-ATP8mitochondrially encoded ATP synthase membrane subunit 8 | Kartais (5–29%) | 1 ligoje |
| PARK7Parkinsonism associated deglycase | Kartais (5–29%) | 1 ligoje |
| PINK1PTEN induced kinase 1 | Kartais (5–29%) | 2 ligose |
| PNPLA6patatin like domain 6, lysophospholipase | Kartais (5–29%) | 1 ligoje |
| PODXLpodocalyxin like | Kartais (5–29%) | 1 ligoje |
| POLGDNA polymerase gamma, catalytic subunit | Kartais (5–29%) | 3 ligose |
| PPP2R2Bprotein phosphatase 2 regulatory subunit Bbeta | Kartais (5–29%) | 2 ligose |
| PRICKLE1prickle planar cell polarity protein 1 | Kartais (5–29%) | 1 ligoje |
| PRKNparkin RBR E3 ubiquitin protein ligase | Kartais (5–29%) | 1 ligoje |
| RAB39BRAB39B, member RAS oncogene family | Kartais (5–29%) | 1 ligoje |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Kartais (5–29%) | 2 ligose |
| SCARB2scavenger receptor class B member 2 | Kartais (5–29%) | 1 ligoje |
| SMPD1sphingomyelin phosphodiesterase 1 | Kartais (5–29%) | 1 ligoje |
| SNCAsynuclein alpha | Kartais (5–29%) | 6 ligose |
| SPG11SPG11 vesicle trafficking associated, spatacsin | Kartais (5–29%) | 1 ligoje |
| SYNJ1synaptojanin 1 | Kartais (5–29%) | 1 ligoje |
| TIMM8Atranslocase of inner mitochondrial membrane 8A | Kartais (5–29%) | 1 ligoje |
| TUBA4Atubulin alpha 4a | Kartais (5–29%) | 1 ligoje |
| TUBB4Atubulin beta 4A class IVa | Kartais (5–29%) | 1 ligoje |
| TWNKtwinkle mtDNA helicase | Kartais (5–29%) | 2 ligose |
| UCHL1ubiquitin C-terminal hydrolase L1 | Kartais (5–29%) | 1 ligoje |
| VPS13Avacuolar protein sorting 13 homolog A | Kartais (5–29%) | 1 ligoje |
| ZFYVE26zinc finger FYVE-type containing 26 | Kartais (5–29%) | 1 ligoje |
| ATRXATRX chromatin remodeler | Retai (1–4 %) | 1 ligoje |
| BRAFB-Raf proto-oncogene, serine/threonine kinase | Retai (1–4 %) | 1 ligoje |
| CDH23cadherin related 23 | Retai (1–4 %) | 1 ligoje |
| DNAJC13DnaJ heat shock protein family (Hsp40) member C13 | Retai (1–4 %) | 1 ligoje |
| DNM1Ldynamin 1L | Retai (1–4 %) | 1 ligoje |
| EIF4G1eukaryotic translation initiation factor 4 gamma 1 | Retai (1–4 %) | 1 ligoje |
| GIGYF2GRB10 interacting GYF protein 2 | Retai (1–4 %) | 1 ligoje |
| LIG3DNA ligase 3 | Retai (1–4 %) | 1 ligoje |
| LMNB1lamin B1 | Retai (1–4 %) | 1 ligoje |
| MMACHCmetabolism of cobalamin associated C | Retai (1–4 %) | 2 ligose |
| MT-TEmitochondrially encoded tRNA-Glu (GAA/G) | Retai (1–4 %) | 1 ligoje |
| NR3C1nuclear receptor subfamily 3 group C member 1 | Retai (1–4 %) | 1 ligoje |
| OPA1OPA1 mitochondrial dynamin like GTPase | Retai (1–4 %) | 1 ligoje |
| PPIBpeptidylprolyl isomerase B | Retai (1–4 %) | 1 ligoje |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Retai (1–4 %) | 1 ligoje |
| SDHAF1succinate dehydrogenase complex assembly factor 1 | Retai (1–4 %) | 1 ligoje |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Retai (1–4 %) | 1 ligoje |
| SDHDsuccinate dehydrogenase complex subunit D | Retai (1–4 %) | 1 ligoje |
| STARD7StAR related lipid transfer domain containing 7 | Retai (1–4 %) | 1 ligoje |
| TP53tumor protein p53 | Retai (1–4 %) | 1 ligoje |
| TYMPthymidine phosphorylase | Retai (1–4 %) | 1 ligoje |
| USP48ubiquitin specific peptidase 48 | Retai (1–4 %) | 1 ligoje |
| USP8ubiquitin specific peptidase 8 | Retai (1–4 %) | 1 ligoje |
| VPS35VPS35 retromer complex component | Retai (1–4 %) | 1 ligoje |
| ABCD1ATP binding cassette subfamily D member 1 | Neužfiksuota | 1 ligoje |
| ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptide | Neužfiksuota | 1 ligoje |
| APTXaprataxin | Neužfiksuota | 1 ligoje |
| ASAH1N-acylsphingosine amidohydrolase 1 | Neužfiksuota | 1 ligoje |
| ATP7BATPase copper transporting beta | Neužfiksuota | 1 ligoje |
| ATXN10ataxin 10 | Neužfiksuota | 1 ligoje |
| ATXN3ataxin 3 | Neužfiksuota | 2 ligose |
| ATXN8OSATXN8 opposite strand lncRNA | Neužfiksuota | 1 ligoje |
| C19orf12chromosome 19 open reading frame 12 | Neužfiksuota | 1 ligoje |
| C9orf72C9orf72-SMCR8 complex subunit | Neužfiksuota | 1 ligoje |
| CFAP43cilia and flagella associated protein 43 | Neužfiksuota | 1 ligoje |
| CLN3CLN3 lysosomal/endosomal transmembrane protein, battenin | Neužfiksuota | 1 ligoje |
| CPceruloplasmin | Neužfiksuota | 1 ligoje |
| CPT1Ccarnitine palmitoyltransferase 1C | Neužfiksuota | 1 ligoje |
| CST3cystatin C | Neužfiksuota | 1 ligoje |
| CUBNcubilin | Neužfiksuota | 1 ligoje |
| CYP27A1cytochrome P450 family 27 subfamily A member 1 | Neužfiksuota | 1 ligoje |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Neužfiksuota | 1 ligoje |
| FTLferritin light chain | Neužfiksuota | 1 ligoje |
| GM2Aganglioside GM2 activator | Neužfiksuota | 1 ligoje |
| HEXAhexosaminidase subunit alpha | Neužfiksuota | 1 ligoje |
| HLA-DQB1major histocompatibility complex, class II, DQ beta 1 | Neužfiksuota | 1 ligoje |
| IRF6interferon regulatory factor 6 | Neužfiksuota | 1 ligoje |
| ITM2Bintegral membrane protein 2B | Neužfiksuota | 2 ligose |
| MMEmembrane metalloendopeptidase | Neužfiksuota | 1 ligoje |
| MPOmyeloperoxidase | Neužfiksuota | 1 ligoje |
| MT-CYBmitochondrially encoded cytochrome b | Neužfiksuota | 1 ligoje |
| MT-TCmitochondrially encoded tRNA-Cys (UGU/C) | Neužfiksuota | 1 ligoje |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Neužfiksuota | 1 ligoje |
| MT-TL2mitochondrially encoded tRNA-Leu (CUN) 2 | Neužfiksuota | 1 ligoje |
| MT-TTmitochondrially encoded tRNA-Thr (ACN) | Neužfiksuota | 1 ligoje |
| MT-TVmitochondrially encoded tRNA-Val (GUN) | Neužfiksuota | 1 ligoje |
| NDPnorrin cystine knot growth factor NDP | Neužfiksuota | 1 ligoje |
| NPC1NPC intracellular cholesterol transporter 1 | Neužfiksuota | 1 ligoje |
| NPC2NPC intracellular cholesterol transporter 2 | Neužfiksuota | 1 ligoje |
| NR4A2nuclear receptor subfamily 4 group A member 2 | Neužfiksuota | 1 ligoje |
| PDE10Aphosphodiesterase 10A | Neužfiksuota | 1 ligoje |
| PLAUplasminogen activator, urokinase | Neužfiksuota | 1 ligoje |
| PRDM8PR/SET domain 8 | Neužfiksuota | 1 ligoje |
| PRDX1peroxiredoxin 1 | Neužfiksuota | 1 ligoje |
| SERPINI1serpin family I member 1 | Neužfiksuota | 1 ligoje |
| SNCAIPsynuclein alpha interacting protein | Neužfiksuota | 1 ligoje |
| SNCBsynuclein beta | Neužfiksuota | 1 ligoje |
| SPASTspastin | Neužfiksuota | 1 ligoje |
| TTRtransthyretin | Neužfiksuota | 1 ligoje |
Kaip dažnai šis požymis pasitaiko žmonėms, turintiems vieną iš geno sukeliamų ligų, ir kuris dažnis tarp jų didžiausias, pagal Žmogaus fenotipo ontologijos duomenis. Šiuose puslapiuose aprašomi požymiai ir juos grindžiantys tyrimai; tai nėra diagnozė, o su simptomais kreipkitės į gydytoją ar genetikos konsultantą.
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- Žmogaus fenotipo ontologija, 2026-09-01 leidimas: požymis, jo pavadinimai, apibrėžimas ir su juo susiję genai. Daugiau sužinokite svetainėje hpo.jax.org.
- Duomenų leidimas 2026.10.16-c6eea6bf.
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