Kenmerk
Mental deterioration
Loss of previously present mental abilities, generally in adults.
Samenvatting
- Ook bekend als
- Cognitive decline, Cognitive decline, progressive, Intellectual deterioration, Progressive cognitive decline
- Lichaamssysteem
- Abnormality of the nervous system
ReferentiegenoomGRCh38hg38
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Mijn Genome Test bestellen189 genen gekoppeld aan Mental deterioration
Veranderingen in deze genen veroorzaken zeldzame aandoeningen waarbij Mental deterioration voorkomt. De meeste mensen met dit kenmerk hebben geen van die aandoeningen, en een gen op deze lijst zegt niets over het eigen genoom van iemand.
| Gen | Hoe vaak het voorkomt | Aandoeningen |
|---|---|---|
| AARS1alanyl-tRNA synthetase 1 | Altijd | In 2 aandoeningen |
| ARHGEF15Rho guanine nucleotide exchange factor 15 | Altijd | In 1 aandoening |
| ATP13A2ATPase cation transporting 13A2 | Altijd | In 2 aandoeningen |
| CARS2cysteinyl-tRNA synthetase 2, mitochondrial | Altijd | In 1 aandoening |
| CLN6CLN6 transmembrane ER protein | Altijd | In 1 aandoening |
| COX6B1cytochrome c oxidase subunit 6B1 | Altijd | In 1 aandoening |
| CTSAcathepsin A | Altijd | In 1 aandoening |
| CTSDcathepsin D | Altijd | In 1 aandoening |
| CTSFcathepsin F | Altijd | In 1 aandoening |
| ERCC6ERCC excision repair 6, chromatin remodeling factor | Altijd | In 1 aandoening |
| FMR1fragile X messenger ribonucleoprotein 1 | Altijd | In 1 aandoening |
| FUCA1alpha-L-fucosidase 1 | Altijd | In 1 aandoening |
| KARS1lysyl-tRNA synthetase 1 | Altijd | In 1 aandoening |
| PLA2G6phospholipase A2 group VI | Altijd | In 3 aandoeningen |
| PLP1proteolipid protein 1 | Altijd | In 2 aandoeningen |
| POLR3KRNA polymerase III subunit K | Altijd | In 1 aandoening |
| RPS6KC1ribosomal protein S6 kinase C1 | Altijd | In 1 aandoening |
| STUB1STIP1 homology and U-box containing protein 1 | Altijd | In 1 aandoening |
| TSPOAP1TSPO associated protein 1 | Altijd | In 2 aandoeningen |
| VPS13Cvacuolar protein sorting 13 homolog C | Altijd | In 1 aandoening |
| WDR45WD repeat domain 45 | Altijd | In 1 aandoening |
| XPAXPA, DNA damage recognition and repair factor | Altijd | In 1 aandoening |
| ABCD1ATP binding cassette subfamily D member 1 | Heel vaak (80–99%) | In 2 aandoeningen |
| ACTBactin beta | Heel vaak (80–99%) | In 1 aandoening |
| APPamyloid beta precursor protein | Heel vaak (80–99%) | In 2 aandoeningen |
| CHMP2Bcharged multivesicular body protein 2B | Heel vaak (80–99%) | In 2 aandoeningen |
| DCAF17DDB1 and CUL4 associated factor 17 | Heel vaak (80–99%) | In 1 aandoening |
| FA2Hfatty acid 2-hydroxylase | Heel vaak (80–99%) | In 3 aandoeningen |
| GALCgalactosylceramidase | Heel vaak (80–99%) | In 3 aandoeningen |
| GRNgranulin precursor | Heel vaak (80–99%) | In 3 aandoeningen |
| HEPACAMhepatic and glial cell adhesion molecule | Heel vaak (80–99%) | In 2 aandoeningen |
| HTThuntingtin | Heel vaak (80–99%) | In 1 aandoening |
| MAPTmicrotubule associated protein tau | Heel vaak (80–99%) | In 6 aandoeningen |
| NBNnibrin | Heel vaak (80–99%) | In 1 aandoening |
| PSAPprosaposin | Heel vaak (80–99%) | In 2 aandoeningen |
| PSEN1presenilin 1 | Heel vaak (80–99%) | In 2 aandoeningen |
| ROGDIrogdi atypical leucine zipper | Heel vaak (80–99%) | In 1 aandoening |
| SLC13A5solute carrier family 13 member 5 | Heel vaak (80–99%) | In 2 aandoeningen |
| SLC2A3solute carrier family 2 member 3 | Heel vaak (80–99%) | In 1 aandoening |
| SLC44A1solute carrier family 44 member 1 | Heel vaak (80–99%) | In 1 aandoening |
Toon nog 149 genen
| Gen | Hoe vaak het voorkomt | Aandoeningen |
|---|---|---|
| SPG11SPG11 vesicle trafficking associated, spatacsin | Heel vaak (80–99%) | In 2 aandoeningen |
| SQSTM1sequestosome 1 | Heel vaak (80–99%) | In 2 aandoeningen |
| TMEM106Btransmembrane protein 106B | Heel vaak (80–99%) | In 2 aandoeningen |
| TREM2triggering receptor expressed on myeloid cells 2 | Heel vaak (80–99%) | In 2 aandoeningen |
| VCPvalosin containing protein | Heel vaak (80–99%) | In 2 aandoeningen |
| ADA2adenosine deaminase 2 | Vaak (30–79%) | In 2 aandoeningen |
| AGKacylglycerol kinase | Vaak (30–79%) | In 1 aandoening |
| AQP4aquaporin 4 | Vaak (30–79%) | In 1 aandoening |
| ATXN7ataxin 7 | Vaak (30–79%) | In 2 aandoeningen |
| CACNA1Acalcium voltage-gated channel subunit alpha1 A | Vaak (30–79%) | In 2 aandoeningen |
| CHD2chromodomain helicase DNA binding protein 2 | Vaak (30–79%) | In 1 aandoening |
| CNTNAP2contactin associated protein 2 | Vaak (30–79%) | In 1 aandoening |
| CPLX1complexin 1 | Vaak (30–79%) | In 1 aandoening |
| CST3cystatin C | Vaak (30–79%) | In 1 aandoening |
| CSTBcystatin B | Vaak (30–79%) | In 1 aandoening |
| CUX2cut like homeobox 2 | Vaak (30–79%) | In 1 aandoening |
| DNM1dynamin 1 | Vaak (30–79%) | In 2 aandoeningen |
| EPG5ectopic P-granules 5 autophagy tethering factor | Vaak (30–79%) | In 1 aandoening |
| EPM2AEPM2A glucan phosphatase, laforin | Vaak (30–79%) | In 1 aandoening |
| FTH1ferritin heavy chain 1 | Vaak (30–79%) | In 1 aandoening |
| GABRB3gamma-aminobutyric acid type A receptor subunit beta3 | Vaak (30–79%) | In 1 aandoening |
| GALTgalactose-1-phosphate uridylyltransferase | Vaak (30–79%) | In 1 aandoening |
| GDAP2ganglioside induced differentiation associated protein 2 | Vaak (30–79%) | In 1 aandoening |
| GOSR2golgi SNAP receptor complex member 2 | Vaak (30–79%) | In 1 aandoening |
| GPRC5BG protein-coupled receptor class C group 5 member B | Vaak (30–79%) | In 1 aandoening |
| HEXBhexosaminidase subunit beta | Vaak (30–79%) | In 1 aandoening |
| HMBShydroxymethylbilane synthase | Vaak (30–79%) | In 1 aandoening |
| JAM2junctional adhesion molecule 2 | Vaak (30–79%) | In 2 aandoeningen |
| KCNC1potassium voltage-gated channel subfamily C member 1 | Vaak (30–79%) | In 1 aandoening |
| MAPK10mitogen-activated protein kinase 10 | Vaak (30–79%) | In 1 aandoening |
| MBTPS2membrane bound transcription factor peptidase, site 2 | Vaak (30–79%) | In 1 aandoening |
| MLC1modulator of VRAC current 1 | Vaak (30–79%) | In 1 aandoening |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Vaak (30–79%) | In 1 aandoening |
| MTHFRmethylenetetrahydrofolate reductase | Vaak (30–79%) | In 1 aandoening |
| NHLRC1NHL repeat containing E3 ubiquitin protein ligase 1 | Vaak (30–79%) | In 1 aandoening |
| PANK2pantothenate kinase 2 | Vaak (30–79%) | In 1 aandoening |
| PRNPprion protein (Kanno blood group) | Vaak (30–79%) | In 2 aandoeningen |
| RRP12ribosomal RNA processing 12 homolog | Vaak (30–79%) | In 1 aandoening |
| SCN1Asodium voltage-gated channel alpha subunit 1 | Vaak (30–79%) | In 3 aandoeningen |
| SCN8Asodium voltage-gated channel alpha subunit 8 | Vaak (30–79%) | In 2 aandoeningen |
| SLC7A6OSsolute carrier family 7 member 6 opposite strand | Vaak (30–79%) | In 1 aandoening |
| SLC9A6solute carrier family 9 member A6 | Vaak (30–79%) | In 1 aandoening |
| SMPD1sphingomyelin phosphodiesterase 1 | Vaak (30–79%) | In 1 aandoening |
| SNORD118small nucleolar RNA, C/D box 118 | Vaak (30–79%) | In 2 aandoeningen |
| SPG21SPG21 abhydrolase domain containing, maspardin | Vaak (30–79%) | In 1 aandoening |
| SYNJ1synaptojanin 1 | Vaak (30–79%) | In 2 aandoeningen |
| TBC1D24TBC1 domain family member 24 | Vaak (30–79%) | In 1 aandoening |
| TBPTATA-box binding protein | Vaak (30–79%) | In 1 aandoening |
| TIMM8Atranslocase of inner mitochondrial membrane 8A | Vaak (30–79%) | In 2 aandoeningen |
| TMEM240transmembrane protein 240 | Vaak (30–79%) | In 1 aandoening |
| AASSaminoadipate-semialdehyde synthase | Soms (5–29%) | In 1 aandoening |
| ACTL6Bactin like 6B | Soms (5–29%) | In 1 aandoening |
| AMACRalpha-methylacyl-CoA racemase | Soms (5–29%) | In 1 aandoening |
| AP3B2adaptor related protein complex 3 subunit beta 2 | Soms (5–29%) | In 1 aandoening |
| APTXaprataxin | Soms (5–29%) | In 1 aandoening |
| ASAH1N-acylsphingosine amidohydrolase 1 | Soms (5–29%) | In 1 aandoening |
| ATP1A2ATPase Na+/K+ transporting subunit alpha 2 | Soms (5–29%) | In 1 aandoening |
| ATP1A3ATPase Na+/K+ transporting subunit alpha 3 | Soms (5–29%) | In 2 aandoeningen |
| ATP6V1AATPase H+ transporting V1 subunit A | Soms (5–29%) | In 1 aandoening |
| CACNA1Bcalcium voltage-gated channel subunit alpha1 B | Soms (5–29%) | In 1 aandoening |
| CACNA2D1calcium voltage-gated channel auxiliary subunit alpha2delta 1 | Soms (5–29%) | In 1 aandoening |
| CDK19cyclin dependent kinase 19 | Soms (5–29%) | In 1 aandoening |
| CELF2CUGBP Elav-like family member 2 | Soms (5–29%) | In 1 aandoening |
| CLTCclathrin heavy chain | Soms (5–29%) | In 1 aandoening |
| CNKSR2connector enhancer of kinase suppressor of Ras 2 | Soms (5–29%) | In 1 aandoening |
| CYFIP2cytoplasmic FMR1 interacting protein 2 | Soms (5–29%) | In 1 aandoening |
| DALRD3DALR anticodon binding domain containing 3 | Soms (5–29%) | In 1 aandoening |
| DARS2aspartyl-tRNA synthetase 2, mitochondrial | Soms (5–29%) | In 1 aandoening |
| DEPDC5DEP domain containing 5, GATOR1 subcomplex subunit | Soms (5–29%) | In 1 aandoening |
| DHDDSdehydrodolichyl diphosphate synthase subunit | Soms (5–29%) | In 1 aandoening |
| DNAJC13DnaJ heat shock protein family (Hsp40) member C13 | Soms (5–29%) | In 1 aandoening |
| DNMT1DNA methyltransferase 1 | Soms (5–29%) | In 1 aandoening |
| EEF1A2eukaryotic translation elongation factor 1 alpha 2 | Soms (5–29%) | In 1 aandoening |
| EIF4G1eukaryotic translation initiation factor 4 gamma 1 | Soms (5–29%) | In 1 aandoening |
| FBXO28F-box protein 28 | Soms (5–29%) | In 1 aandoening |
| FGF12fibroblast growth factor 12 | Soms (5–29%) | In 1 aandoening |
| FOXG1forkhead box G1 | Soms (5–29%) | In 1 aandoening |
| FZR1fizzy and cell division cycle 20 related 1 | Soms (5–29%) | In 1 aandoening |
| GABBR2gamma-aminobutyric acid type B receptor subunit 2 | Soms (5–29%) | In 1 aandoening |
| GABRA2gamma-aminobutyric acid type A receptor subunit alpha2 | Soms (5–29%) | In 1 aandoening |
| GABRA5gamma-aminobutyric acid type A receptor subunit alpha5 | Soms (5–29%) | In 1 aandoening |
| GABRB2gamma-aminobutyric acid type A receptor subunit beta2 | Soms (5–29%) | In 1 aandoening |
| GABRG2gamma-aminobutyric acid type A receptor subunit gamma2 | Soms (5–29%) | In 1 aandoening |
| GBA1glucosylceramidase beta 1 | Soms (5–29%) | In 1 aandoening |
| GIGYF2GRB10 interacting GYF protein 2 | Soms (5–29%) | In 1 aandoening |
| GRIN2Dglutamate ionotropic receptor NMDA type subunit 2D | Soms (5–29%) | In 1 aandoening |
| HCN1hyperpolarization activated cyclic nucleotide gated potassium channel 1 | Soms (5–29%) | In 1 aandoening |
| HTRA1HtrA serine peptidase 1 | Soms (5–29%) | In 2 aandoeningen |
| KCNA2potassium voltage-gated channel subfamily A member 2 | Soms (5–29%) | In 1 aandoening |
| KCNB1potassium voltage-gated channel subfamily B member 1 | Soms (5–29%) | In 1 aandoening |
| KCNC2potassium voltage-gated channel subfamily C member 2 | Soms (5–29%) | In 1 aandoening |
| KCNH5potassium voltage-gated channel subfamily H member 5 | Soms (5–29%) | In 1 aandoening |
| L1CAML1 cell adhesion molecule | Soms (5–29%) | In 1 aandoening |
| LIG3DNA ligase 3 | Soms (5–29%) | In 1 aandoening |
| LRRK2leucine rich repeat kinase 2 | Soms (5–29%) | In 1 aandoening |
| MAP2K1mitogen-activated protein kinase kinase 1 | Soms (5–29%) | In 1 aandoening |
| MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2 | Soms (5–29%) | In 1 aandoening |
| MFN2mitofusin 2 | Soms (5–29%) | In 1 aandoening |
| MMACHCmetabolism of cobalamin associated C | Soms (5–29%) | In 1 aandoening |
| MYORGmyogenesis regulating glycosidase | Soms (5–29%) | In 2 aandoeningen |
| NECAP1NECAP endocytosis associated 1 | Soms (5–29%) | In 1 aandoening |
| NRASNRAS proto-oncogene, GTPase | Soms (5–29%) | In 2 aandoeningen |
| NTRK2neurotrophic receptor tyrosine kinase 2 | Soms (5–29%) | In 1 aandoening |
| NUS1NUS1 dehydrodolichyl diphosphate synthase subunit | Soms (5–29%) | In 1 aandoening |
| PACS2phosphofurin acidic cluster sorting protein 2 | Soms (5–29%) | In 1 aandoening |
| PARS2prolyl-tRNA synthetase 2, mitochondrial | Soms (5–29%) | In 1 aandoening |
| PPP3CAprotein phosphatase 3 catalytic subunit alpha | Soms (5–29%) | In 1 aandoening |
| PRDM8PR/SET domain 8 | Soms (5–29%) | In 1 aandoening |
| SCN3Asodium voltage-gated channel alpha subunit 3 | Soms (5–29%) | In 1 aandoening |
| SLC1A2solute carrier family 1 member 2 | Soms (5–29%) | In 1 aandoening |
| SLC38A3solute carrier family 38 member 3 | Soms (5–29%) | In 1 aandoening |
| SNCAsynuclein alpha | Soms (5–29%) | In 2 aandoeningen |
| SYNGAP1synaptic Ras GTPase activating protein 1 | Soms (5–29%) | In 1 aandoening |
| SZT2SZT2 subunit of KICSTOR complex | Soms (5–29%) | In 1 aandoening |
| TRAK1trafficking kinesin protein 1 | Soms (5–29%) | In 1 aandoening |
| TTPAalpha tocopherol transfer protein | Soms (5–29%) | In 1 aandoening |
| UBA5ubiquitin like modifier activating enzyme 5 | Soms (5–29%) | In 1 aandoening |
| UBAP1ubiquitin associated protein 1 | Soms (5–29%) | In 1 aandoening |
| UFSP2UFM1 specific peptidase 2 | Soms (5–29%) | In 1 aandoening |
| VPS13Avacuolar protein sorting 13 homolog A | Soms (5–29%) | In 1 aandoening |
| VPS35VPS35 retromer complex component | Soms (5–29%) | In 1 aandoening |
| YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma | Soms (5–29%) | In 1 aandoening |
| KCNQ2potassium voltage-gated channel subfamily Q member 2 | Zelden (1–4%) | In 1 aandoening |
| SCN2Asodium voltage-gated channel alpha subunit 2 | Zelden (1–4%) | In 1 aandoening |
| TLR3toll like receptor 3 | Zelden (1–4%) | In 1 aandoening |
| AP5Z1adaptor related protein complex 5 subunit zeta 1 | Niet vastgelegd | In 1 aandoening |
| ARSAarylsulfatase A | Niet vastgelegd | In 1 aandoening |
| BSCL2BSCL2 lipid droplet biogenesis associated, seipin | Niet vastgelegd | In 1 aandoening |
| C19orf12chromosome 19 open reading frame 12 | Niet vastgelegd | In 1 aandoening |
| CLN8CLN8 transmembrane ER and ERGIC protein | Niet vastgelegd | In 1 aandoening |
| COASYCoenzyme A synthase | Niet vastgelegd | In 1 aandoening |
| CSF1Rcolony stimulating factor 1 receptor | Niet vastgelegd | In 2 aandoeningen |
| CTC1CST telomere replication complex component 1 | Niet vastgelegd | In 1 aandoening |
| ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit | Niet vastgelegd | In 1 aandoening |
| GBA2glucosylceramidase beta 2 | Niet vastgelegd | In 1 aandoening |
| GNASGNAS complex locus | Niet vastgelegd | In 1 aandoening |
| MFSD8major facilitator superfamily domain containing 8 | Niet vastgelegd | In 1 aandoening |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Niet vastgelegd | In 1 aandoening |
| PDE10Aphosphodiesterase 10A | Niet vastgelegd | In 1 aandoening |
| PDE11Aphosphodiesterase 11A | Niet vastgelegd | In 1 aandoening |
| PDGFBplatelet derived growth factor subunit B | Niet vastgelegd | In 1 aandoening |
| PDGFRBplatelet derived growth factor receptor beta | Niet vastgelegd | In 1 aandoening |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Niet vastgelegd | In 1 aandoening |
| PRKCGprotein kinase C gamma | Niet vastgelegd | In 1 aandoening |
| SGPL1sphingosine-1-phosphate lyase 1 | Niet vastgelegd | In 1 aandoening |
| SLC20A2solute carrier family 20 member 2 | Niet vastgelegd | In 1 aandoening |
| TBK1TANK binding kinase 1 | Niet vastgelegd | In 1 aandoening |
| UBTFupstream binding transcription factor | Niet vastgelegd | In 1 aandoening |
| XPR1xenotropic and polytropic retrovirus receptor 1 | Niet vastgelegd | In 1 aandoening |
Hoe vaak dit voorkomt bij mensen met een van de aandoeningen van het gen, de hoogste frequentie binnen die aandoeningen, zoals de Human Phenotype Ontology dit vastlegt. Deze pagina's beschrijven kenmerken en het onderzoek erachter; het zijn geen diagnose, en over symptomen kunt u het best een arts of genetisch adviseur raadplegen.
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Waar dit vandaan komt
- De Human Phenotype Ontology, release 2026-09-01: het kenmerk, de namen, de definitie en de genen die ermee verbonden zijn. Meer informatie vindt u op hpo.jax.org.
- Gegevensrelease 2026.10.16-c6eea6bf.
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