Trait

Wide nasal bridge

Increased breadth of the nasal bridge (and with it, the nasal root).

Also called: Broad flat nasal bridge, Broad nasal bridge, Broad nasal root, Broadened nasal bridge, Increased breadth of bridge of nose, Increased breadth of nasal bridge, Increased width of bridge of nose, Increased width of nasal bridge, Nasal bridge broad, Wide bridge of nose, Widened nasal bridge, Nasal bridge, wide
Body system: Abnormality of head or neck

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215 condition reports read genes linked to this trait

Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.

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538 genes linked to Wide nasal bridge

Changes in these genes cause rare conditions in which Wide nasal bridge is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
AGO1argonaute RISC component 1	Always	In 1 condition
ALX1ALX homeobox 1	Always	In 2 conditions
ALX3ALX homeobox 3	Always	In 1 condition
ALX4ALX homeobox 4	Always	In 1 condition
ANKHANKH inorganic pyrophosphate transport regulator	Always	In 2 conditions
AP3B1adaptor related protein complex 3 subunit beta 1	Always	In 1 condition
APC2APC regulator of Wnt signaling pathway 2	Always	In 1 condition
CAMSAP1calmodulin regulated spectrin associated protein 1	Always	In 1 condition
CDH11cadherin 11	Always	In 1 condition
CHD8chromodomain helicase DNA binding protein 8	Always	In 2 conditions
CILK1ciliogenesis associated kinase 1	Always	In 2 conditions
CLP1cleavage factor polyribonucleotide kinase subunit 1	Always	In 2 conditions
CREBBPCREB binding lysine acetyltransferase	Always	In 1 condition
CRNKL1crooked neck pre-mRNA splicing factor 1	Always	In 1 condition
DHX9DExH-box helicase 9	Always	In 1 condition
DIS3L2DIS3 like 3'-5' exoribonuclease 2	Always	In 2 conditions
DMRT2doublesex and mab-3 related transcription factor 2	Always	In 1 condition
DRG1developmentally regulated GTP binding protein 1	Always	In 1 condition
DVL1dishevelled segment polarity protein 1	Always	In 3 conditions
DVL3dishevelled segment polarity protein 3	Always	In 2 conditions
EIF4A2eukaryotic translation initiation factor 4A2	Always	In 1 condition
EP300EP300 lysine acetyltransferase	Always	In 1 condition
ERI1exoribonuclease 1	Always	In 1 condition
ESAMendothelial cell adhesion molecule	Always	In 1 condition
FBXO31F-box protein 31	Always	In 1 condition
FGD1FYVE, RhoGEF and PH domain containing 1	Always	In 2 conditions
FGFR1fibroblast growth factor receptor 1	Always	In 2 conditions
FILIP1filamin A interacting protein 1	Always	In 1 condition
FLNAfilamin A	Always	In 5 conditions
FLVCR1FLVCR choline and heme transporter 1	Always	In 1 condition
GPC3glypican 3	Always	In 2 conditions
HYAL2hyaluronidase 2	Always	In 1 condition
HYOU1hypoxia up-regulated 1	Always	In 1 condition
IDUAalpha-L-iduronidase	Always	In 2 conditions
IFT122intraflagellar transport 122	Always	In 1 condition
IFT140intraflagellar transport 140	Always	In 2 conditions
IFT52intraflagellar transport 52	Always	In 1 condition
IRX5iroquois homeobox 5	Always	In 1 condition
JKAMPJNK1/MAPK8 associated membrane protein	Always	In 1 condition
KDM1Alysine demethylase 1A	Always	In 2 conditions

Show 498 more genes

Gene	How often it is seen	Conditions
KIAA0753KIAA0753	Always	In 2 conditions
KIF7kinesin family member 7	Always	In 3 conditions
LIG4DNA ligase 4	Always	In 2 conditions
LRRC7leucine rich repeat containing 7	Always	In 1 condition
LTBP1latent transforming growth factor beta binding protein 1	Always	In 1 condition
LTBP4latent transforming growth factor beta binding protein 4	Always	In 1 condition
MAP3K7mitogen-activated protein kinase kinase kinase 7	Always	In 3 conditions
MAPRE2microtubule associated protein RP/EB family member 2	Always	In 1 condition
MDGA2MAM domain containing glycosylphosphatidylinositol anchor 2	Always	In 1 condition
MED12mediator complex subunit 12	Always	In 1 condition
MGPmatrix Gla protein	Always	In 1 condition
MYCNMYCN proto-oncogene, bHLH transcription factor	Always	In 2 conditions
MYH3myosin heavy chain 3	Always	In 3 conditions
MYT1Lmyelin transcription factor 1 like	Always	In 1 condition
NALCNsodium leak channel, non-selective	Always	In 4 conditions
NAV3neuron navigator 3	Always	In 1 condition
NBNnibrin	Always	In 1 condition
NDE1nudE neurodevelopment protein 1	Always	In 2 conditions
NFASCneurofascin	Always	In 1 condition
NUDT2nudix hydrolase 2	Always	In 1 condition
NUP188nucleoporin 188	Always	In 1 condition
NUP88nucleoporin 88	Always	In 1 condition
OFD1OFD1 centriole and centriolar satellite protein	Always	In 3 conditions
PAX3paired box 3	Always	In 3 conditions
PDGFRBplatelet derived growth factor receptor beta	Always	In 1 condition
PEX10peroxisomal biogenesis factor 10	Always	In 3 conditions
PEX12peroxisomal biogenesis factor 12	Always	In 3 conditions
PEX14peroxisomal biogenesis factor 14	Always	In 3 conditions
PEX19peroxisomal biogenesis factor 19	Always	In 3 conditions
PGAP2post-GPI attachment to proteins 2	Always	In 2 conditions
PGAP3post-GPI attachment to proteins phospholipase 3	Always	In 2 conditions
PIGLphosphatidylinositol glycan anchor biosynthesis class L	Always	In 2 conditions
PIGOphosphatidylinositol glycan anchor biosynthesis class O	Always	In 2 conditions
PIGWphosphatidylinositol glycan anchor biosynthesis class W	Always	In 2 conditions
PPFIA3PPFI scaffold protein A3	Always	In 1 condition
PSMD12proteasome 26S subunit, non-ATPase 12	Always	In 2 conditions
RAC3Rac family small GTPase 3	Always	In 1 condition
RAD21RAD21 cohesin complex component	Always	In 2 conditions
RAPSNreceptor associated protein of the synapse	Always	In 1 condition
RBL2RB transcriptional corepressor like 2	Always	In 1 condition
RIN2Ras and Rab interactor 2	Always	In 1 condition
RNU2-2RNA, U2 small nuclear 2	Always	In 1 condition
RSRC1arginine and serine rich coiled-coil 1	Always	In 1 condition
SCNM1sodium channel modifier 1	Always	In 1 condition
SCO2synthesis of cytochrome C oxidase 2	Always	In 1 condition
SEC23ASEC23 homolog A, COPII component	Always	In 1 condition
SETD5SET domain containing 5	Always	In 1 condition
SIN3ASIN3 transcription regulator family member A	Always	In 1 condition
SKIC2SKI2 subunit of superkiller complex	Always	In 2 conditions
SLC35A2solute carrier family 35 member A2	Always	In 1 condition
SMARCAL1SNF2 related chromatin remodeling annealing helicase 1	Always	In 1 condition
SNAP29synaptosome associated protein 29	Always	In 1 condition
SPOUT1SPOUT domain containing methyltransferase 1	Always	In 1 condition
SRD5A3steroid 5 alpha-reductase 3	Always	In 1 condition
STRADASTE20 related adaptor alpha	Always	In 1 condition
TAF4TATA-box binding protein associated factor 4	Always	In 1 condition
TASP1taspase 1	Always	In 1 condition
TMCO1transmembrane and coiled-coil domains 1	Always	In 1 condition
TOR1Atorsin family 1 member A	Always	In 1 condition
UBAP2Lubiquitin associated protein 2 like	Always	In 1 condition
UGGT1UDP-glucose glycoprotein glucosyltransferase 1	Always	In 1 condition
UNC13Aunc-13 homolog A	Always	In 1 condition
VDRvitamin D receptor	Always	In 1 condition
WDR19WD repeat domain 19	Always	In 1 condition
ZSWIM6zinc finger SWIM-type containing 6	Always	In 1 condition
ACTBactin beta	Very often (80–99%)	In 3 conditions
ACTG1actin gamma 1	Very often (80–99%)	In 1 condition
ADAMTS3ADAM metallopeptidase with thrombospondin type 1 motif 3	Very often (80–99%)	In 1 condition
ADAMTSL2ADAMTS like 2	Very often (80–99%)	In 1 condition
AGAaspartylglucosaminidase	Very often (80–99%)	In 1 condition
ARVCFARVCF delta catenin family member	Very often (80–99%)	In 1 condition
ATP6V1B2ATPase H+ transporting V1 subunit B2	Very often (80–99%)	In 1 condition
BAZ1Bbromodomain adjacent to zinc finger domain 1B	Very often (80–99%)	In 1 condition
BCL11ABCL11 transcription factor A	Very often (80–99%)	In 1 condition
BUD23BUD23 rRNA methyltransferase and ribosome maturation factor	Very often (80–99%)	In 1 condition
CASZ1castor zinc finger 1	Very often (80–99%)	In 1 condition
CCBE1collagen and calcium binding EGF domains 1	Very often (80–99%)	In 2 conditions
CCDC22CCC complex scaffolding subunit CCDC22	Very often (80–99%)	In 1 condition
CKAP2Lcytoskeleton associated protein 2L	Very often (80–99%)	In 2 conditions
CLIP2CAP-Gly domain containing linker protein 2	Very often (80–99%)	In 1 condition
COL11A1collagen type XI alpha 1 chain	Very often (80–99%)	In 1 condition
COMTcatechol-O-methyltransferase	Very often (80–99%)	In 1 condition
CPLX1complexin 1	Very often (80–99%)	In 2 conditions
CTBP1C-terminal binding protein 1	Very often (80–99%)	In 2 conditions
CTNND2catenin delta 2	Very often (80–99%)	In 1 condition
DHCR77-dehydrocholesterol reductase	Very often (80–99%)	In 2 conditions
DNAJC30DnaJ heat shock protein family (Hsp40) member C30	Very often (80–99%)	In 1 condition
DPYSL5dihydropyrimidinase like 5	Very often (80–99%)	In 2 conditions
EFNB1ephrin B1	Very often (80–99%)	In 2 conditions
EIF4Heukaryotic translation initiation factor 4H	Very often (80–99%)	In 1 condition
ELNelastin	Very often (80–99%)	In 1 condition
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit	Very often (80–99%)	In 1 condition
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit	Very often (80–99%)	In 1 condition
ERCC5ERCC excision repair 5, endonuclease	Very often (80–99%)	In 1 condition
ERCC6ERCC excision repair 6, chromatin remodeling factor	Very often (80–99%)	In 1 condition
FAT4FAT atypical cadherin 4	Very often (80–99%)	In 3 conditions
FKBP6FKBP prolyl isomerase family member 6 (inactive)	Very often (80–99%)	In 1 condition
FZD2frizzled class receptor 2	Very often (80–99%)	In 2 conditions
GABRDgamma-aminobutyric acid type A receptor subunit delta	Very often (80–99%)	In 1 condition
GJA1gap junction protein alpha 1	Very often (80–99%)	In 2 conditions
GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Very often (80–99%)	In 2 conditions
GP1BBglycoprotein Ib platelet subunit beta	Very often (80–99%)	In 1 condition
GTF2Igeneral transcription factor IIi	Very often (80–99%)	In 1 condition
GTF2IRD1GTF2I repeat domain containing 1	Very often (80–99%)	In 1 condition
GTF2IRD2GTF2I repeat domain containing 2	Very often (80–99%)	In 1 condition
HIRAhistone cell cycle regulator	Very often (80–99%)	In 1 condition
HSPG2heparan sulfate proteoglycan 2	Very often (80–99%)	In 3 conditions
INTS1integrator complex subunit 1	Very often (80–99%)	In 1 condition
JMJD1Cjumonji domain containing 1C	Very often (80–99%)	In 1 condition
KCNAB2potassium voltage-gated channel subfamily A regulatory beta subunit 2	Very often (80–99%)	In 1 condition
KCNMA1potassium calcium-activated channel subfamily M alpha 1	Very often (80–99%)	In 1 condition
KDM6Alysine demethylase 6A	Very often (80–99%)	In 1 condition
KMT2Alysine methyltransferase 2A	Very often (80–99%)	In 2 conditions
KMT2Dlysine methyltransferase 2D	Very often (80–99%)	In 2 conditions
LETM1leucine zipper and EF-hand containing transmembrane protein 1	Very often (80–99%)	In 2 conditions
LIMK1LIM domain kinase 1	Very often (80–99%)	In 1 condition
LMNAlamin A/C	Very often (80–99%)	In 1 condition
LUZP1leucine zipper protein 1	Very often (80–99%)	In 1 condition
METTL27methyltransferase like 27	Very often (80–99%)	In 1 condition
MID1midline 1	Very often (80–99%)	In 2 conditions
MMP23Bmatrix metallopeptidase 23B	Very often (80–99%)	In 1 condition
NCF1neutrophil cytosolic factor 1	Very often (80–99%)	In 1 condition
NELFAnegative elongation factor complex member A	Very often (80–99%)	In 1 condition
NEU1neuraminidase 1	Very often (80–99%)	In 1 condition
NSD2nuclear receptor binding SET domain protein 2	Very often (80–99%)	In 3 conditions
NXNnucleoredoxin	Very often (80–99%)	In 2 conditions
PDE4Dphosphodiesterase 4D	Very often (80–99%)	In 1 condition
PDPNpodoplanin	Very often (80–99%)	In 1 condition
PEX1peroxisomal biogenesis factor 1	Very often (80–99%)	In 3 conditions
PEX11Bperoxisomal biogenesis factor 11 beta	Very often (80–99%)	In 2 conditions
PEX13peroxisomal biogenesis factor 13	Very often (80–99%)	In 2 conditions
PEX16peroxisomal biogenesis factor 16	Very often (80–99%)	In 2 conditions
PEX2peroxisomal biogenesis factor 2	Very often (80–99%)	In 2 conditions
PEX26peroxisomal biogenesis factor 26	Very often (80–99%)	In 2 conditions
PEX3peroxisomal biogenesis factor 3	Very often (80–99%)	In 2 conditions
PEX5peroxisomal biogenesis factor 5	Very often (80–99%)	In 3 conditions
PEX6peroxisomal biogenesis factor 6	Very often (80–99%)	In 2 conditions
PIGGphosphatidylinositol glycan anchor biosynthesis class G (EMM blood group)	Very often (80–99%)	In 1 condition
PIGNphosphatidylinositol glycan anchor biosynthesis class N	Very often (80–99%)	In 1 condition
PIGVphosphatidylinositol glycan anchor biosynthesis class V	Very often (80–99%)	In 2 conditions
PQBP1polyglutamine binding protein 1	Very often (80–99%)	In 2 conditions
PRDM16PR/SET domain 16	Very often (80–99%)	In 1 condition
PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha	Very often (80–99%)	In 1 condition
PRKCZprotein kinase C zeta	Very often (80–99%)	In 1 condition
PTH1Rparathyroid hormone 1 receptor	Very often (80–99%)	In 1 condition
RAB18RAB18, member RAS oncogene family	Very often (80–99%)	In 1 condition
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1	Very often (80–99%)	In 2 conditions
RAB3GAP2RAB3 GTPase activating non-catalytic protein subunit 2	Very often (80–99%)	In 1 condition
RAI1retinoic acid induced 1	Very often (80–99%)	In 2 conditions
RB1RB transcriptional corepressor 1	Very often (80–99%)	In 1 condition
RELREL proto-oncogene, NF-kB subunit	Very often (80–99%)	In 1 condition
REREarginine-glutamic acid dipeptide repeats	Very often (80–99%)	In 1 condition
RFC2replication factor C subunit 2	Very often (80–99%)	In 1 condition
ROR2ROR family WNT receptor 2	Very often (80–99%)	In 2 conditions
RREB1ras responsive element binding protein 1	Very often (80–99%)	In 1 condition
SEC24CSEC24 homolog C, COPII component	Very often (80–99%)	In 1 condition
SEMA5Asemaphorin 5A	Very often (80–99%)	In 1 condition
SH3PXD2BSH3 and PX domains 2B	Very often (80–99%)	In 1 condition
SHOXSHOX homeobox	Very often (80–99%)	In 1 condition
SKISKI proto-oncogene	Very often (80–99%)	In 1 condition
SOSTsclerostin	Very often (80–99%)	In 3 conditions
SP7Sp7 transcription factor	Very often (80–99%)	In 1 condition
SPENspen family transcriptional repressor	Very often (80–99%)	In 2 conditions
STX1Asyntaxin 1A	Very often (80–99%)	In 1 condition
TBC1D20TBC1 domain family member 20	Very often (80–99%)	In 1 condition
TBC1D24TBC1 domain family member 24	Very often (80–99%)	In 2 conditions
TBC1D7TBC1 domain family member 7	Very often (80–99%)	In 1 condition
TBL2transducin beta like 2	Very often (80–99%)	In 1 condition
TBX1T-box transcription factor 1	Very often (80–99%)	In 1 condition
TMEM270transmembrane protein 270	Very often (80–99%)	In 1 condition
TRAPPC9trafficking protein particle complex subunit 9	Very often (80–99%)	In 2 conditions
TWIST2twist family bHLH transcription factor 2	Very often (80–99%)	In 2 conditions
UBE4Bubiquitination factor E4B	Very often (80–99%)	In 1 condition
UFD1ubiquitin recognition factor in ER associated degradation 1	Very often (80–99%)	In 1 condition
VPS35LVPS35 endosomal protein sorting factor like	Very often (80–99%)	In 1 condition
VPS37DVPS37D subunit of ESCRT-I	Very often (80–99%)	In 1 condition
WASHC5WASH complex subunit 5	Very often (80–99%)	In 1 condition
WNT5AWnt family member 5A	Very often (80–99%)	In 2 conditions
XPO1exportin 1	Very often (80–99%)	In 1 condition
ABCC9ATP binding cassette subfamily C member 9	Often (30–79%)	In 2 conditions
ADAMTSL1ADAMTS like 1	Often (30–79%)	In 1 condition
ADNPactivity dependent neuroprotector homeobox	Often (30–79%)	In 1 condition
ALG2ALG2 alpha-1,3/1,6-mannosyltransferase	Often (30–79%)	In 2 conditions
AMER1APC membrane recruitment protein 1	Often (30–79%)	In 2 conditions
ARID1BAT-rich interaction domain 1B	Often (30–79%)	In 1 condition
ARSKarylsulfatase family member K	Often (30–79%)	In 1 condition
ASXL1ASXL transcriptional regulator 1	Often (30–79%)	In 2 conditions
ASXL3ASXL transcriptional regulator 3	Often (30–79%)	In 1 condition
ATP6V1AATPase H+ transporting V1 subunit A	Often (30–79%)	In 1 condition
AUTS2activator of transcription and developmental regulator AUTS2	Often (30–79%)	In 2 conditions
B4GALT1beta-1,4-galactosyltransferase 1	Often (30–79%)	In 1 condition
B4GALT7beta-1,4-galactosyltransferase 7	Often (30–79%)	In 2 conditions
BPTFbromodomain PHD finger transcription factor	Often (30–79%)	In 1 condition
BRAFB-Raf proto-oncogene, serine/threonine kinase	Often (30–79%)	In 1 condition
C1GALT1C1C1GALT1 specific chaperone 1	Often (30–79%)	In 1 condition
CASKcalcium/calmodulin dependent serine protein kinase	Often (30–79%)	In 3 conditions
CCNQcyclin Q	Often (30–79%)	In 1 condition
CDK10cyclin dependent kinase 10	Often (30–79%)	In 1 condition
COG1component of oligomeric golgi complex 1	Often (30–79%)	In 2 conditions
COX7Bcytochrome c oxidase subunit 7B	Often (30–79%)	In 1 condition
CTNNB1catenin beta 1	Often (30–79%)	In 1 condition
DOT1LDOT1 like histone lysine methyltransferase	Often (30–79%)	In 1 condition
DPH5diphthamide biosynthesis 5	Often (30–79%)	In 1 condition
EBF3EBF transcription factor 3	Often (30–79%)	In 1 condition
EDN3endothelin 3	Often (30–79%)	In 1 condition
EDNRBendothelin receptor type B	Often (30–79%)	In 1 condition
ERFETS2 repressor factor	Often (30–79%)	In 1 condition
EXOC2exocyst complex component 2	Often (30–79%)	In 1 condition
FBN1fibrillin 1	Often (30–79%)	In 1 condition
FGF3fibroblast growth factor 3	Often (30–79%)	In 1 condition
FGFRL1fibroblast growth factor receptor like 1	Often (30–79%)	In 1 condition
FOXL2forkhead box L2	Often (30–79%)	In 2 conditions
FREM1FRAS1 related extracellular matrix 1	Often (30–79%)	In 2 conditions
FUT8fucosyltransferase 8	Often (30–79%)	In 1 condition
GATA4GATA binding protein 4	Often (30–79%)	In 1 condition
GLI3GLI family zinc finger 3	Often (30–79%)	In 2 conditions
GLULglutamate-ammonia ligase	Often (30–79%)	In 1 condition
GON4Lgon-4 like	Often (30–79%)	In 1 condition
GPC4glypican 4	Often (30–79%)	In 1 condition
GPRASP2G protein-coupled receptor associated sorting protein 2	Often (30–79%)	In 1 condition
HBA1hemoglobin subunit alpha 1	Often (30–79%)	In 1 condition
HBA2hemoglobin subunit alpha 2	Often (30–79%)	In 1 condition
HCCSholocytochrome c synthase	Often (30–79%)	In 1 condition
HIVEP2HIVEP zinc finger 2	Often (30–79%)	In 1 condition
HNRNPKheterogeneous nuclear ribonucleoprotein K	Often (30–79%)	In 2 conditions
IGF1Rinsulin like growth factor 1 receptor	Often (30–79%)	In 2 conditions
KAT6Blysine acetyltransferase 6B	Often (30–79%)	In 1 condition
KATNB1katanin regulatory subunit B1	Often (30–79%)	In 1 condition
KCNH1potassium voltage-gated channel subfamily H member 1	Often (30–79%)	In 2 conditions
KCNJ8potassium inwardly rectifying channel subfamily J member 8	Often (30–79%)	In 1 condition
KCNN3potassium calcium-activated channel subfamily N member 3	Often (30–79%)	In 1 condition
KICS2KICSTOR subunit 2	Often (30–79%)	In 1 condition
KIF14kinesin family member 14	Often (30–79%)	In 1 condition
KNSTRNkinetochore localized astrin (SPAG5) binding protein	Often (30–79%)	In 2 conditions
LTBP3latent transforming growth factor beta binding protein 3	Often (30–79%)	In 1 condition
MAN1B1mannosidase alpha class 1B member 1	Often (30–79%)	In 2 conditions
MARS2methionyl-tRNA synthetase 2, mitochondrial	Often (30–79%)	In 1 condition
MED13Lmediator complex subunit 13L	Often (30–79%)	In 1 condition
MEGF8multiple EGF like domains 8	Often (30–79%)	In 1 condition
MITFmelanocyte inducing transcription factor	Often (30–79%)	In 2 conditions
MKS1MKS transition zone complex subunit 1	Often (30–79%)	In 1 condition
MYRFmyelin regulatory factor	Often (30–79%)	In 1 condition
NDUFB11NADH:ubiquinone oxidoreductase subunit B11	Often (30–79%)	In 1 condition
NECTIN1nectin cell adhesion molecule 1	Often (30–79%)	In 1 condition
NEK1NIMA related kinase 1	Often (30–79%)	In 1 condition
NOGnoggin	Often (30–79%)	In 1 condition
PACS2phosphofurin acidic cluster sorting protein 2	Often (30–79%)	In 1 condition
PAN2poly(A) specific ribonuclease subunit PAN2	Often (30–79%)	In 1 condition
PAX1paired box 1	Often (30–79%)	In 1 condition
PCNTpericentrin	Often (30–79%)	In 1 condition
PIGTphosphatidylinositol glycan anchor biosynthesis class T	Often (30–79%)	In 1 condition
PIGYphosphatidylinositol glycan anchor biosynthesis class Y	Often (30–79%)	In 1 condition
PIK3C2Aphosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Often (30–79%)	In 2 conditions
PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Often (30–79%)	In 2 conditions
PKDCCprotein kinase domain containing, cytoplasmic	Often (30–79%)	In 1 condition
PLK4polo like kinase 4	Often (30–79%)	In 1 condition
POLR1BRNA polymerase I subunit B	Often (30–79%)	In 1 condition
POLR1CRNA polymerase I and III subunit C	Often (30–79%)	In 1 condition
POLR1DRNA polymerase I and III subunit D	Often (30–79%)	In 1 condition
PPP1R21protein phosphatase 1 regulatory subunit 21	Often (30–79%)	In 1 condition
PRKG2protein kinase cGMP-dependent 2	Often (30–79%)	In 1 condition
PTCH1patched 1	Often (30–79%)	In 3 conditions
PTCH2patched 2	Often (30–79%)	In 1 condition
PTPN11protein tyrosine phosphatase non-receptor type 11	Often (30–79%)	In 1 condition
PUF60poly(U) binding splicing factor 60	Often (30–79%)	In 3 conditions
PUM1pumilio RNA binding family member 1	Often (30–79%)	In 1 condition
QARS1glutaminyl-tRNA synthetase 1	Often (30–79%)	In 1 condition
RAF1Raf-1 proto-oncogene, serine/threonine kinase	Often (30–79%)	In 1 condition
RBM10RNA binding motif protein 10	Often (30–79%)	In 2 conditions
RELNreelin	Often (30–79%)	In 1 condition
RHOAras homolog family member A	Often (30–79%)	In 1 condition
RLIMring finger protein, LIM domain interacting	Often (30–79%)	In 1 condition
RUNX2RUNX family transcription factor 2	Often (30–79%)	In 1 condition
SETD2SET domain containing 2, histone lysine methyltransferase	Often (30–79%)	In 1 condition
SKIC3SKI3 subunit of superkiller complex	Often (30–79%)	In 1 condition
SLC12A6solute carrier family 12 member 6	Often (30–79%)	In 1 condition
SMARCA2SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2	Often (30–79%)	In 1 condition
SMG9SMG9 nonsense mediated mRNA decay factor	Often (30–79%)	In 2 conditions
SOX10SRY-box transcription factor 10	Often (30–79%)	In 2 conditions
SPECC1Lsperm antigen with calponin homology and coiled-coil domains 1 like	Often (30–79%)	In 2 conditions
STAT3signal transducer and activator of transcription 3	Often (30–79%)	In 1 condition
STRA6signaling receptor and transporter of retinol STRA6	Often (30–79%)	In 1 condition
STT3ASTT3 oligosaccharyltransferase complex catalytic subunit A	Often (30–79%)	In 1 condition
SUFUSUFU negative regulator of hedgehog signaling	Often (30–79%)	In 1 condition
SUPT16HSPT16 homolog, facilitates chromatin remodeling subunit	Often (30–79%)	In 2 conditions
TBX6T-box transcription factor 6	Often (30–79%)	In 1 condition
TCOF1treacle ribosome biogenesis factor 1	Often (30–79%)	In 1 condition
TFAP2Atranscription factor AP-2 alpha	Often (30–79%)	In 1 condition
TNNI2troponin I2, fast skeletal type	Often (30–79%)	In 2 conditions
TNNT3troponin T3, fast skeletal type	Often (30–79%)	In 1 condition
TOE1target of EGR1, exonuclease	Often (30–79%)	In 2 conditions
TOGARAM1TOG array regulator of axonemal microtubules 1	Often (30–79%)	In 1 condition
TPM2tropomyosin 2	Often (30–79%)	In 1 condition
TPRtranslocated promoter region, nuclear basket protein	Often (30–79%)	In 1 condition
TRIM33tripartite motif containing 33	Often (30–79%)	In 1 condition
TRIM37tripartite motif containing 37	Often (30–79%)	In 2 conditions
TRMT1tRNA methyltransferase 1	Often (30–79%)	In 1 condition
TUBGCP4tubulin gamma complex component 4	Often (30–79%)	In 1 condition
TUBGCP6tubulin gamma complex component 6	Often (30–79%)	In 1 condition
TWIST1twist family bHLH transcription factor 1	Often (30–79%)	In 1 condition
UMPSuridine monophosphate synthetase	Often (30–79%)	In 1 condition
VPS33AVPS33A core subunit of CORVET and HOPS complexes	Often (30–79%)	In 1 condition
WLSWnt ligand secretion mediator	Often (30–79%)	In 1 condition
YARS1tyrosyl-tRNA synthetase 1	Often (30–79%)	In 1 condition
ZEB2zinc finger E-box binding homeobox 2	Often (30–79%)	In 3 conditions
AGO2argonaute RISC catalytic component 2	Sometimes (5–29%)	In 1 condition
AHDC1AT-hook DNA binding motif containing 1	Sometimes (5–29%)	In 1 condition
AP4B1adaptor related protein complex 4 subunit beta 1	Sometimes (5–29%)	In 1 condition
ARMC9armadillo repeat containing 9	Sometimes (5–29%)	In 1 condition
BCAS3BCAS3 microtubule associated cell migration factor	Sometimes (5–29%)	In 1 condition
BMP2bone morphogenetic protein 2	Sometimes (5–29%)	In 1 condition
BPNT23'(2'), 5'-bisphosphate nucleotidase 2	Sometimes (5–29%)	In 1 condition
BRF1BRF1 general transcription factor IIIB subunit	Sometimes (5–29%)	In 1 condition
CDC42cell division cycle 42	Sometimes (5–29%)	In 2 conditions
CDK13cyclin dependent kinase 13	Sometimes (5–29%)	In 1 condition
CHN1chimerin 1	Sometimes (5–29%)	In 1 condition
COG5component of oligomeric golgi complex 5	Sometimes (5–29%)	In 1 condition
CSNK2A1casein kinase 2 alpha 1	Sometimes (5–29%)	In 1 condition
CTCFCCCTC-binding factor	Sometimes (5–29%)	In 1 condition
CTSDcathepsin D	Sometimes (5–29%)	In 1 condition
DCHS1dachsous cadherin-related 1	Sometimes (5–29%)	In 2 conditions
DHRS3dehydrogenase/reductase 3	Sometimes (5–29%)	In 1 condition
DLK1delta like non-canonical Notch ligand 1	Sometimes (5–29%)	In 1 condition
EDEM3ER degradation enhancing alpha-mannosidase like protein 3	Sometimes (5–29%)	In 1 condition
EXT1exostosin glycosyltransferase 1	Sometimes (5–29%)	In 1 condition
FANCLFA complementation group L	Sometimes (5–29%)	In 1 condition
FBXL3F-box and leucine rich repeat protein 3	Sometimes (5–29%)	In 1 condition
FBXL4F-box and leucine rich repeat protein 4	Sometimes (5–29%)	In 1 condition
FBXO11F-box protein 11	Sometimes (5–29%)	In 1 condition
FEM1Bfem-1 homolog B	Sometimes (5–29%)	In 1 condition
FLI1Fli-1 proto-oncogene, ETS transcription factor	Sometimes (5–29%)	In 1 condition
FOXC1forkhead box C1	Sometimes (5–29%)	In 1 condition
FRAS1Fraser extracellular matrix complex subunit 1	Sometimes (5–29%)	In 2 conditions
FREM2FRAS1 related extracellular matrix 2	Sometimes (5–29%)	In 1 condition
FRMPD4FERM and PDZ domain containing 4	Sometimes (5–29%)	In 1 condition
GABBR1gamma-aminobutyric acid type B receptor subunit 1	Sometimes (5–29%)	In 1 condition
GAD1glutamate decarboxylase 1	Sometimes (5–29%)	In 1 condition
GNPNAT1glucosamine-phosphate N-acetyltransferase 1	Sometimes (5–29%)	In 1 condition
GRIP1glutamate receptor interacting protein 1	Sometimes (5–29%)	In 1 condition
GTF3C3general transcription factor IIIC subunit 3	Sometimes (5–29%)	In 1 condition
H4C5H4 clustered histone 5	Sometimes (5–29%)	In 1 condition
HECTD4HECT domain E3 ubiquitin protein ligase 4	Sometimes (5–29%)	In 1 condition
HNRNPRheterogeneous nuclear ribonucleoprotein R	Sometimes (5–29%)	In 1 condition
HS2ST1heparan sulfate 2-O-sulfotransferase 1	Sometimes (5–29%)	In 1 condition
JARID2jumonji and AT-rich interaction domain containing 2	Sometimes (5–29%)	In 1 condition
KCNJ2potassium inwardly rectifying channel subfamily J member 2	Sometimes (5–29%)	In 1 condition
KCNJ5potassium inwardly rectifying channel subfamily J member 5	Sometimes (5–29%)	In 1 condition
KDM2Blysine demethylase 2B	Sometimes (5–29%)	In 1 condition
KDM4Blysine demethylase 4B	Sometimes (5–29%)	In 1 condition
KIF11kinesin family member 11	Sometimes (5–29%)	In 1 condition
KIFBPkinesin family binding protein	Sometimes (5–29%)	In 2 conditions
KITKIT proto-oncogene, receptor tyrosine kinase	Sometimes (5–29%)	In 1 condition
KMT5Blysine methyltransferase 5B	Sometimes (5–29%)	In 1 condition
KPTNkaptin, actin binding protein	Sometimes (5–29%)	In 1 condition
KRASKRas proto-oncogene, GTPase	Sometimes (5–29%)	In 1 condition
KREMEN1kringle containing transmembrane protein 1	Sometimes (5–29%)	In 1 condition
LGI1leucine rich glioma inactivated 1	Sometimes (5–29%)	In 1 condition
LMNB1lamin B1	Sometimes (5–29%)	In 1 condition
LRPPRCleucine rich pentatricopeptide repeat containing	Sometimes (5–29%)	In 1 condition
LZTR1leucine zipper like post translational regulator 1	Sometimes (5–29%)	In 1 condition
MAFBMAF bZIP transcription factor B	Sometimes (5–29%)	In 2 conditions
MAPK1mitogen-activated protein kinase 1	Sometimes (5–29%)	In 1 condition
MARK2microtubule affinity regulating kinase 2	Sometimes (5–29%)	In 1 condition
MECP2methyl-CpG binding protein 2	Sometimes (5–29%)	In 1 condition
MEG3maternally expressed 3	Sometimes (5–29%)	In 1 condition
MPV17mitochondrial inner membrane protein MPV17	Sometimes (5–29%)	In 1 condition
NOTCH2notch receptor 2	Sometimes (5–29%)	In 1 condition
NSUN2NOP2/Sun RNA methyltransferase 2	Sometimes (5–29%)	In 1 condition
OPHN1oligophrenin 1	Sometimes (5–29%)	In 1 condition
PAHphenylalanine hydroxylase	Sometimes (5–29%)	In 1 condition
PIGBphosphatidylinositol glycan anchor biosynthesis class B	Sometimes (5–29%)	In 2 conditions
PIK3R1phosphoinositide-3-kinase regulatory subunit 1	Sometimes (5–29%)	In 2 conditions
PITX2paired like homeodomain 2	Sometimes (5–29%)	In 2 conditions
POLR1ARNA polymerase I subunit A	Sometimes (5–29%)	In 1 condition
PRKDCprotein kinase, DNA-activated, catalytic subunit	Sometimes (5–29%)	In 1 condition
PRMT7protein arginine methyltransferase 7	Sometimes (5–29%)	In 1 condition
PURApurine rich element binding protein A	Sometimes (5–29%)	In 2 conditions
RAB34RAB34, member RAS oncogene family	Sometimes (5–29%)	In 1 condition
RFX7regulatory factor X7	Sometimes (5–29%)	In 1 condition
RMRPRNA component of mitochondrial RNA processing endoribonuclease	Sometimes (5–29%)	In 1 condition
RPL10ribosomal protein L10	Sometimes (5–29%)	In 1 condition
RTL1retrotransposon Gag like 1	Sometimes (5–29%)	In 1 condition
RTTNrotatin	Sometimes (5–29%)	In 1 condition
RYR1ryanodine receptor 1	Sometimes (5–29%)	In 1 condition
SALL4spalt like transcription factor 4	Sometimes (5–29%)	In 1 condition
SCN4Asodium voltage-gated channel alpha subunit 4	Sometimes (5–29%)	In 2 conditions
SEPHS1selenophosphate synthetase 1	Sometimes (5–29%)	In 1 condition
SETSET nuclear proto-oncogene	Sometimes (5–29%)	In 1 condition
SHANK3SH3 and multiple ankyrin repeat domains 3	Sometimes (5–29%)	In 1 condition
SLC1A4solute carrier family 1 member 4	Sometimes (5–29%)	In 1 condition
SLC35C1solute carrier family 35 member C1	Sometimes (5–29%)	In 1 condition
SLC4A10solute carrier family 4 member 10	Sometimes (5–29%)	In 1 condition
SNAI2snail family transcriptional repressor 2	Sometimes (5–29%)	In 1 condition
SNX14sorting nexin 14	Sometimes (5–29%)	In 1 condition
SONSON DNA and RNA binding protein	Sometimes (5–29%)	In 2 conditions
SOX6SRY-box transcription factor 6	Sometimes (5–29%)	In 1 condition
SPTBN1spectrin beta, non-erythrocytic 1	Sometimes (5–29%)	In 1 condition
SVBPsmall vasohibin binding protein	Sometimes (5–29%)	In 1 condition
TBCKTBC1 domain containing kinase	Sometimes (5–29%)	In 2 conditions
TMEM53transmembrane protein 53	Sometimes (5–29%)	In 1 condition
TP63tumor protein p63	Sometimes (5–29%)	In 2 conditions
TRIOtrio Rho guanine nucleotide exchange factor	Sometimes (5–29%)	In 1 condition
TRPS1transcriptional repressor GATA binding 1	Sometimes (5–29%)	In 1 condition
TRPV6transient receptor potential cation channel subfamily V member 6	Sometimes (5–29%)	In 1 condition
TXNL4Athioredoxin like 4A	Sometimes (5–29%)	In 1 condition
USP9Xubiquitin specific peptidase 9 X-linked	Sometimes (5–29%)	In 2 conditions
WACWW domain containing adaptor with coiled-coil	Sometimes (5–29%)	In 1 condition
WARS2tryptophanyl tRNA synthetase 2, mitochondrial	Sometimes (5–29%)	In 1 condition
ZMYM2zinc finger MYM-type containing 2	Sometimes (5–29%)	In 1 condition
ZSCAN10zinc finger and SCAN domain containing 10	Sometimes (5–29%)	In 1 condition
ADA2adenosine deaminase 2	Rarely (1–4%)	In 1 condition
AP2M1adaptor related protein complex 2 subunit mu 1	Rarely (1–4%)	In 1 condition
CHD2chromodomain helicase DNA binding protein 2	Rarely (1–4%)	In 1 condition
GATA1GATA binding protein 1	Rarely (1–4%)	In 1 condition
HEATR3HEAT repeat containing 3	Rarely (1–4%)	In 1 condition
MED16mediator complex subunit 16	Rarely (1–4%)	In 1 condition
NEXMIFneurite extension and migration factor	Rarely (1–4%)	In 1 condition
RNU4-2RNA, U4 small nuclear 2	Rarely (1–4%)	In 1 condition
RPL11ribosomal protein L11	Rarely (1–4%)	In 1 condition
RPL15ribosomal protein L15	Rarely (1–4%)	In 1 condition
RPL18ribosomal protein L18	Rarely (1–4%)	In 1 condition
RPL26ribosomal protein L26	Rarely (1–4%)	In 1 condition
RPL27ribosomal protein L27	Rarely (1–4%)	In 1 condition
RPL31ribosomal protein L31	Rarely (1–4%)	In 1 condition
RPL35ribosomal protein L35	Rarely (1–4%)	In 1 condition
RPL35Aribosomal protein L35a	Rarely (1–4%)	In 1 condition
RPL5ribosomal protein L5	Rarely (1–4%)	In 1 condition
RPL8ribosomal protein L8	Rarely (1–4%)	In 1 condition
RPL9ribosomal protein L9	Rarely (1–4%)	In 1 condition
RPS10ribosomal protein S10	Rarely (1–4%)	In 1 condition
RPS15Aribosomal protein S15a	Rarely (1–4%)	In 1 condition
RPS17ribosomal protein S17	Rarely (1–4%)	In 1 condition
RPS19ribosomal protein S19	Rarely (1–4%)	In 1 condition
RPS20ribosomal protein S20	Rarely (1–4%)	In 1 condition
RPS24ribosomal protein S24	Rarely (1–4%)	In 1 condition
RPS26ribosomal protein S26	Rarely (1–4%)	In 1 condition
RPS27ribosomal protein S27	Rarely (1–4%)	In 1 condition
RPS28ribosomal protein S28	Rarely (1–4%)	In 1 condition
RPS29ribosomal protein S29	Rarely (1–4%)	In 1 condition
RPS7ribosomal protein S7	Rarely (1–4%)	In 2 conditions
SCN1Asodium voltage-gated channel alpha subunit 1	Rarely (1–4%)	In 1 condition
SLC2A1solute carrier family 2 member 1	Rarely (1–4%)	In 1 condition
SLC6A1solute carrier family 6 member 1	Rarely (1–4%)	In 1 condition
SYNGAP1synaptic Ras GTPase activating protein 1	Rarely (1–4%)	In 1 condition
TSR2TSR2 ribosome maturation factor	Rarely (1–4%)	In 1 condition
ACOX1acyl-CoA oxidase 1	Not recorded	In 1 condition
ACY1aminoacylase 1	Not recorded	In 1 condition
AHI1Abelson helper integration site 1	Not recorded	In 1 condition
ALG3ALG3 alpha-1,3- mannosyltransferase	Not recorded	In 1 condition
AP4E1adaptor related protein complex 4 subunit epsilon 1	Not recorded	In 1 condition
AP4S1adaptor related protein complex 4 subunit sigma 1	Not recorded	In 1 condition
ARXaristaless related homeobox	Not recorded	In 1 condition
ATAD3AATPase family AAA domain containing 3A	Not recorded	In 1 condition
ATP6V0A2ATPase H+ transporting V0 subunit a2	Not recorded	In 1 condition
ATRXATRX chromatin remodeler	Not recorded	In 1 condition
CCNKcyclin K	Not recorded	In 1 condition
CD96CD96 molecule	Not recorded	In 1 condition
CENPFcentromere protein F	Not recorded	In 1 condition
CHD3chromodomain helicase DNA binding protein 3	Not recorded	In 1 condition
COL27A1collagen type XXVII alpha 1 chain	Not recorded	In 1 condition
COLEC11collectin subfamily member 11	Not recorded	In 1 condition
DDX3XDEAD-box helicase 3 X-linked	Not recorded	In 1 condition
EDNRAendothelin receptor type A	Not recorded	In 1 condition
EEDembryonic ectoderm development	Not recorded	In 1 condition
ESCO2establishment of sister chromatid cohesion N-acetyltransferase 2	Not recorded	In 1 condition
FLNBfilamin B	Not recorded	In 1 condition
G6PC3glucose-6-phosphatase catalytic subunit 3	Not recorded	In 1 condition
GATAD2BGATA zinc finger domain containing 2B	Not recorded	In 1 condition
GNPATglyceronephosphate O-acyltransferase	Not recorded	In 1 condition
GPC6glypican 6	Not recorded	In 1 condition
IFT57intraflagellar transport 57	Not recorded	In 1 condition
LARP7La ribonucleoprotein 7, transcriptional regulator	Not recorded	In 1 condition
MAFMAF bZIP transcription factor	Not recorded	In 1 condition
MED13mediator complex subunit 13	Not recorded	In 1 condition
NAA10N-alpha-acetyltransferase 10, NatA catalytic subunit	Not recorded	In 1 condition
NRASNRAS proto-oncogene, GTPase	Not recorded	In 1 condition
OTUD6BOTU deubiquitinase 6B	Not recorded	In 1 condition
PARS2prolyl-tRNA synthetase 2, mitochondrial	Not recorded	In 1 condition
PBX1PBX homeobox 1	Not recorded	In 1 condition
PDHA1pyruvate dehydrogenase E1 subunit alpha 1	Not recorded	In 1 condition
PIEZO2piezo type mechanosensitive ion channel component 2	Not recorded	In 1 condition
PUS7pseudouridine synthase 7	Not recorded	In 1 condition
RALARAS like proto-oncogene A	Not recorded	In 1 condition
RARBretinoic acid receptor beta	Not recorded	In 1 condition
SOX18SRY-box transcription factor 18	Not recorded	In 1 condition
SOX5SRY-box transcription factor 5	Not recorded	In 1 condition
SRCAPSnf2 related CREBBP activator protein	Not recorded	In 1 condition
STAG2STAG2 cohesin complex component	Not recorded	In 1 condition
TAPT1transmembrane anterior posterior transformation 1	Not recorded	In 1 condition
TCF4transcription factor 4	Not recorded	In 1 condition
TENT5Aterminal nucleotidyltransferase 5A	Not recorded	In 1 condition
TMEM70transmembrane protein 70	Not recorded	In 1 condition
TMEM94transmembrane protein 94	Not recorded	In 1 condition
TNPO2transportin 2	Not recorded	In 1 condition
TRRAPtransformation/transcription domain associated protein	Not recorded	In 1 condition
WDR35WD repeat domain 35	Not recorded	In 1 condition
WNT7AWnt family member 7A	Not recorded	In 1 condition
ZMIZ1zinc finger MIZ-type containing 1	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormality of the bridge of the nose

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.19-9814e911.

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