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Gene

RELN

reelin

Summary

Cytogenetic location
7q22.1
Coordinates
Chromosome 7: 103,471,789–103,989,658 (GRCh38)
Exons
65 exons across 517.9 kb
Protein
3,460 amino acids
Also known as
RL, PRO1598
MANE Select transcript
ENST00000428762.6NM_005045.4
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • 2 GenCC submitters rate it definitive or strong

    How RELN is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 7, with a bracket where RELN sits. RELN and 9 genes near it on chromosome 7, from 102,953,919 to 104,507,528.Chromosome 77q22.1p22.3p22.2p22.1p21.3p21.2p21.1p15.3p15.2p15.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.21q11.22q11.23q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q31.1q31.2q31.31q31.32q31.33q32.1q32.2q32.3q33q34q35q36.1q36.2q36.3103 Mb103.2 Mb103.4 Mb103.6 Mb103.8 Mb104 Mb104.2 Mb104.4 MbFBXL13: 102,811,020–103,075,400, reverse strandFBXL13ARMC10: 103,074,625–103,103,945, forward strandARMC10NAPEPLD: 103,099,776–103,151,172, reverse strandNAPEPLDPMPCB: 103,295,717–103,342,067, forward strandPMPCBDNAJC2: 103,310,497–103,344,837, reverse strandDNAJC2PSMC2: 103,328,570–103,370,346, forward strandPSMC2SLC26A5: 103,352,730–103,446,212, reverse strandSLC26A5RELN: 103,471,789–103,989,658, reverse strandRELNORC5: 104,126,341–104,208,047, reverse strandORC5LHFPL3: 104,328,603–104,908,561, forward strandLHFPL3Diagram of RELN: 65 exons on the reverse strand of chromosome 7Exon 65: 1 known disease-causing siteExon 62: 1 known disease-causing siteExon 61: 2 known disease-causing sitesExon 59: 2 known disease-causing sitesExon 57: 1 known disease-causing siteExon 56: 2 known disease-causing sitesExon 55: 1 known disease-causing siteExon 54: 2 known disease-causing sitesExon 53: 1 known disease-causing siteExon 52: 1 known disease-causing siteExon 50: 2 known disease-causing sitesExon 49: 1 known disease-causing siteExon 45: 1 known disease-causing siteExon 44: 1 known disease-causing siteExon 43: 3 known disease-causing sitesExon 42: 3 known disease-causing sitesExon 41: 1 known disease-causing siteExon 39: 1 known disease-causing siteExon 37: 1 known disease-causing siteExon 36: 2 known disease-causing sitesExon 35: 1 known disease-causing siteExon 34: 3 known disease-causing sitesExon 33: 2 known disease-causing sitesExon 32: 3 known disease-causing sitesExon 30: 2 known disease-causing sitesExon 29: 1 known disease-causing siteExon 27: 2 known disease-causing sitesExon 26: 1 known disease-causing siteExon 25: 4 known disease-causing sitesExon 24: 1 known disease-causing siteExon 23: 1 known disease-causing siteExon 22: 2 known disease-causing sitesExon 21: 1 known disease-causing siteExon 20: 2 known disease-causing sitesExon 19: 2 known disease-causing sitesExon 18: 2 known disease-causing sitesExon 16: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 65: 103,471,789–103,472,908, 1,120 basesExon 64: 103,478,389–103,478,394, 6 basesExon 63: 103,482,873–103,482,971, 99 basesExon 62: 103,483,653–103,483,850, 198 basesExon 61: 103,486,197–103,486,416, 220 basesExon 60: 103,489,742–103,489,899, 158 basesExon 59: 103,490,668–103,490,829, 162 basesExon 58: 103,491,953–103,492,026, 74 basesExon 57: 103,495,723–103,495,898, 176 basesExon 56: 103,496,526–103,496,768, 243 basesExon 55: 103,497,820–103,497,926, 107 basesExon 54: 103,498,077–103,498,252, 176 basesExon 53: 103,500,745–103,500,922, 178 basesExon 52: 103,503,016–103,503,230, 215 basesExon 51: 103,510,851–103,511,005, 155 basesExon 50: 103,515,185–103,515,441, 257 basesExon 49: 103,519,323–103,519,516, 194 basesExon 48: 103,522,022–103,522,199, 178 basesExon 47: 103,523,391–103,523,531, 141 basesExon 46: 103,535,316–103,535,484, 169 basesExon 45: 103,539,078–103,539,327, 250 basesExon 44: 103,540,197–103,540,455, 259 basesExon 43: 103,542,731–103,542,878, 148 basesExon 42: 103,545,124–103,545,344, 221 basesExon 41: 103,551,067–103,551,296, 230 basesExon 40: 103,553,461–103,553,563, 103 basesExon 39: 103,553,660–103,553,831, 172 basesExon 38: 103,556,977–103,557,159, 183 basesExon 37: 103,557,965–103,558,049, 85 basesExon 36: 103,561,532–103,561,709, 178 basesExon 35: 103,561,813–103,561,953, 141 basesExon 34: 103,565,278–103,565,551, 274 basesExon 33: 103,566,224–103,566,412, 189 basesExon 32: 103,566,601–103,566,759, 159 basesExon 31: 103,572,184–103,572,260, 77 basesExon 30: 103,574,092–103,574,299, 208 basesExon 29: 103,575,548–103,575,705, 158 basesExon 28: 103,589,596–103,589,828, 233 basesExon 27: 103,593,682–103,593,882, 201 basesExon 26: 103,594,321–103,594,492, 172 basesExon 25: 103,596,456–103,596,661, 206 basesExon 24: 103,603,304–103,603,490, 187 basesExon 23: 103,604,346–103,604,483, 138 basesExon 22: 103,610,695–103,610,807, 113 basesExon 21: 103,611,611–103,611,803, 193 basesExon 20: 103,629,940–103,630,176, 237 basesExon 19: 103,635,425–103,635,586, 162 basesExon 18: 103,636,235–103,636,468, 234 basesExon 17: 103,640,543–103,640,609, 67 basesExon 16: 103,650,274–103,650,383, 110 basesExon 15: 103,651,661–103,651,789, 129 basesExon 14: 103,652,551–103,652,759, 209 basesExon 13: 103,654,093–103,654,205, 113 basesExon 12: 103,661,376–103,661,527, 152 basesExon 11: 103,682,116–103,682,261, 146 basesExon 10: 103,697,853–103,698,093, 241 basesExon 9: 103,700,910–103,701,006, 97 basesExon 8: 103,723,140–103,723,191, 52 basesExon 7: 103,728,111–103,728,207, 97 basesExon 6: 103,749,426–103,749,504, 79 basesExon 5: 103,753,182–103,753,214, 33 basesExon 4: 103,776,557–103,776,627, 71 basesExon 3: 103,833,537–103,833,672, 136 basesExon 2: 103,917,075–103,917,185, 111 basesExon 1: 103,989,131–103,989,658, 528 bases6560504030201015′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 11.7 kb of the gene's 517.9 kb; 10,383 of those bases code for the protein.

    How a genome test reads RELN

    84

    positions in RELN where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 517.9 kb of RELN, introns included, not only the 11.7 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). RELN gene: reelin. Retrieved 16 October 2026, from https://dantelabs.com/genes/reln

    Vancouver

    Dante Labs. RELN gene: reelin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/reln

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