Gene
LRRC7
leucine rich repeat containing 7
- HGNC 18531↗(opens in a new tab)
- Ensembl gene ENSG00000033122↗(opens in a new tab)
- NCBI Gene 57554↗(opens in a new tab)
Summary
- Cytogenetic location
- 1p31.1
- Coordinates
- Chromosome 1: 69,567,922–70,144,364 (GRCh38)
- Exons
- 27 exons across 576.4 kb
- Protein
- 1,575 amino acids
- Also known as
- KIAA1365, densin-180
- MANE Select transcript
- ENST00000651989.2NM_001370785.2
- Locus type
- Protein-coding
- Very high
- Confident
- Low
- Very low
This page as data
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page <- fromJSON(url)
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How LRRC7 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 27.9 kb of the gene's 576.4 kb; 4,728 of those bases code for the protein.
Traits linked to LRRC7
The Human Phenotype Ontology lists these as features of the rare conditions LRRC7 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Anxiety
- Ataxia
- Attention deficit
- Autism spectrum disorder
- Behavioral abnormality
- Brief seizures with staring spells
- Can't control feelings
- Cerebellar vermis atrophy
Show 64 more traits
- Cerebral palsy
- Chiari type I malformation
- Clumsiness
- Complex febrile seizure
- Decreased reflex response
- Delayed ability to sit
- Delayed fine motor development
- Delayed motor skills
- Depression
- Difficulty articulating speech
- Difficulty falling asleep
- Dysgraphia
- Dystonia
- EEG abnormality
- Febrile seizure (within the age range of 3 months to 6 years)
- Fluid-filled cyst in spinal cord
- Frequent temper tantrums
- Global developmental delay
- Grammar-specific speech disorder
- Hallucinations
- Hallucinations of sound
- Hand tremor
- Headache
- Impulsivity
- Inability to coordinate movements when walking
- Inability to speak
- Inability to walk
- Incoordination
- Increased appetite
- Intellectual disability
- Intellectual disability, mild
- Intellectual disability, severe
- IQ between 34 and 49
- Irritability
- Low frustration tolerance
- Migraine
- Mild global developmental delay
- Moderate global developmental delay
- Moderate receptive language delay
- Pain insensitivity
- Pauses in breathing while sleeping
- Psychosis
- Reading disability
- Reduced impulse control
- Resting tremor
- Restlessness
- Selective mutism
- Self-injurious behavior
- Severe global developmental delay
- Short attention span
- Short corpus callosum
- Slow movements
- Thin corpus callosum
- Typical absence seizure
- Underdevelopment of part of brain called corpus callosum
- Unsteady walk
- Visual hallucinations
- Aggressive behavior
- Autism
- Delayed speech and language development
- Delayed ability to walk
- Epilepsy
- Difficulty sleeping
- Interictal epileptiform activity
Abnormality of the musculoskeletal system
- Appendicular hypotonia
- Basal ganglia calcification
- Cogwheel rigidity
- Double-Jointed
- Generalized decreased muscle tone
- Kyphoscoliosis
- Low muscle tone, in neonatal onset
- Muscle weakness
Show 4 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). LRRC7 gene: leucine rich repeat containing 7. Retrieved 18 October 2026, from https://dantelabs.com/genes/lrrc7
Dante Labs. LRRC7 gene: leucine rich repeat containing 7 [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/lrrc7
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