Gene
PRMT7
protein arginine methyltransferase 7
- HGNC 25557(opens in a new tab)
- Ensembl gene ENSG00000132600(opens in a new tab)
- NCBI Gene 54496(opens in a new tab)
Summary
- Cytogenetic location
- 16q22.1
- Coordinates
- Chromosome 16: 68,311,019–68,358,584 (GRCh38)
- Exons
- 19 exons across 47.6 kb
- Protein
- 692 amino acids
- Also known as
- FLJ10640, KIAA1933
- MANE Select transcript
- ENST00000441236.3NM_019023.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Intellectual Disability
One of 233 genes linked to it
- 3 GenCC submitters rate it definitive or strong
How PRMT7 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.7 kb of the gene's 47.6 kb; 2,079 of those bases code for the protein.
How a genome test reads PRMT7
33
positions in PRMT7 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 47.6 kb of PRMT7, introns included, not only the 3.7 kb of exons.
Traits linked to PRMT7
The Human Phenotype Ontology lists these as features of the rare conditions PRMT7 can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Broad head shape
- Decreased volume of lip
- Flattened bony protrusion above eyes
- Hairy forehead
- Long philtrum
- Redundant neck skin
- Short neck
- Abnormal facial shape
Show 20 more traits
- Flat face
- Flat nose
- Gum enlargement
- Nasal tip, upturned
- Prominent forehead
- Short nose
- Short opening between the eyelids
- Zygomatic flattening
- Abnormally small head
- Broad nasal tip
- Collapsed nostrils
- Dacryocystitis
- Dental crowding
- Depressed nasal bridge
- Eye folds
- Receding chin
- Skin tag in front of the ear
- Wide nasal bridge
- Frontal bossing
- High palate
Abnormality of the nervous system
- Delayed ability to walk
- Delayed CNS myelination
- Delayed speech and language development
- Global developmental delay
- Severe global developmental delay
- Short attention span
- Sudden loss of muscle tone
- Tethered cord
Show 13 more traits
- Intellectual disability
- Abnormal shape of brain
- Epilepsy
- Intellectual disability, mild
- Intellectual disability, severe
- Specific learning disability
- Typical absence seizure
- Abnormal conus terminalis morphology
- IQ between 34 and 49
- Pauses in breathing while sleeping
- Seizure affecting one half of brain
- Thick corpus callosum
- Underdevelopment of part of brain called corpus callosum
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). PRMT7 gene: protein arginine methyltransferase 7. Retrieved 16 October 2026, from https://dantelabs.com/genes/prmt7
Dante Labs. PRMT7 gene: protein arginine methyltransferase 7 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/prmt7
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