Gene
WNT5A
Wnt family member 5A
- HGNC 12784↗(opens in a new tab)
- Ensembl gene ENSG00000114251↗(opens in a new tab)
- NCBI Gene 7474↗(opens in a new tab)
Summary
- Cytogenetic location
- 3p14.3
- Coordinates
- Chromosome 3: 55,465,715–55,487,306 (GRCh38)
- Exons
- 5 exons across 21.6 kb
- Protein
- 380 amino acids
- Also known as
- hWNT5A
- MANE Select transcript
- ENST00000264634.9NM_003392.7
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome TestCurated reports relevant to this gene
No Genome Test report reads WNT5A yet. The test sequences your whole genome, so your data includes it all the same.
How WNT5A is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 5.8 kb of the gene's 21.6 kb; 1,143 of those bases code for the protein.
How a genome test reads WNT5A
7
positions in WNT5A where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 21.6 kb of WNT5A, introns included, not only the 5.8 kb of exons.
Traits linked to WNT5A
The Human Phenotype Ontology lists these as features of the rare conditions WNT5A can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Short nose
- Midface retrusion
- Nasal tip, upturned
- Wide nasal bridge
- Wide nose
- Abnormality of the gums
- Big calvaria
- Broad opening between the eyelids
Show 38 more traits
- Central cleft palate
- Cleft tongue
- Curly eyelashes
- Delayed loss of baby teeth
- Depressed nasal bridge
- Downturned corners of mouth
- Downward slanting of the opening between the eyelids
- Euryblepharon
- Eye folds
- Flat face
- Frontal bossing
- Gum enlargement
- High, narrow palate
- Little lower jaw
- Long eyelashes
- Long philtrum
- Open bite
- Prominent forehead
- Receding chin
- Short lingual frenulum
- Upward slanting of the opening between the eyelids
- Wider-than-typical soft spot of skull
- Zygomatic flattening
- Extra teeth
- Failure of development of all teeth
- Failure of development of between one and six teeth
- Failure of development of more than six teeth
- Short neck
- Short philtrum
- Abnormally large tongue
- Cleft of the mouth
- Delayed eruption of teeth
- Dental crowding
- High palate
- Narrow palate
- Short hard palate
- Thin red part of the upper lip
- Triangular mouth
Abnormality of limbs
- Short fingers or toes
- Short palm
- Smaller or shorter than typical limbs
- Curvature of little finger
- Dislocated radial head
- Limited elbow extension and supination
- Avascular necrosis of the capital femoral epiphysis
- Coxa valga
Show 15 more traits
- Coxa vara
- Elbow dislocation
- Finger syndactyly
- Hip dislocation
- Permanent flexion of the finger
- Broad thumb
- Broad toe
- Curvature of digit
- Disproportionately short middle portion of limb
- Disproportionately short upper portion of limb
- Duplication of the outermost bone of hand
- Notched outermost bones of toes
- Radial deviation of finger
- Short middle bone of the little finger
- Small hand
Abnormality of the genitourinary system
- Underdeveloped penis
- Small clitoris
- Small labia majora
- Underdeveloped inner lips
- Undescended testes
- Abnormality of the penis
- Epispadias
- Hypospadias
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). WNT5A gene: Wnt family member 5A. Retrieved 17 October 2026, from https://dantelabs.com/genes/wnt5a
Dante Labs. WNT5A gene: Wnt family member 5A [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/wnt5a
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