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Gene

MARK2

microtubule affinity regulating kinase 2

Summary

Cytogenetic location
11q13.1
Coordinates
Chromosome 11: 63,839,110–63,911,020 (GRCh38)
Exons
19 exons across 71.9 kb
Protein
788 amino acids
Also known as
PAR-1, Par1b, PAR-1B
Previous symbols
EMK1
MANE Select transcript
ENST00000402010.8NM_001039469.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MARK2 yet. The test sequences your whole genome, so your data includes it all the same.

How MARK2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where MARK2 sits. MARK2 and 35 genes near it on chromosome 11, from 63,375,065 to 64,375,064.Chromosome 1111q13.1p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2563.4 Mb63.6 Mb63.8 Mb64 Mb64.2 MbSLC22A9: 63,369,217–63,411,798, forward strandSLC22A9PLAAT5: 63,461,404–63,491,228, reverse strandPLAAT5LGALS12: 63,505,966–63,519,767, forward strandLGALS12PLAAT4: 63,529,451–63,549,076, forward strandPLAAT4PLAAT2: 63,552,770–63,564,157, reverse strandPLAAT2PLAAT3: 63,569,750–63,616,901, reverse strandPLAAT3ATL3: 63,624,087–63,671,921, reverse strandATL3RTN3: 63,681,444–63,759,909, forward strandRTN3ZFTA: 63,759,892–63,769,752, reverse strandZFTASPINDOC: 63,813,405–63,827,718, forward strandSPINDOCMARK2: 63,839,110–63,911,020, forward strandMARK2RCOR2: 63,910,992–63,919,787, reverse strandRCOR2NAA40: 63,938,669–63,957,324, forward strandNAA40COX8A: 63,974,579–63,976,543, forward strandCOX8AOTUB1: 63,985,853–64,001,811, forward strandOTUB1MACROD1: 63,998,553–64,166,501, reverse strandMACROD1FLRT1: 64,035,757–64,119,403, forward strandFLRT1STIP1: 64,185,272–64,204,549, forward strandSTIP1FERMT3: 64,205,926–64,223,896, forward strandFERMT3TRPT1: 64,223,799–64,226,823, reverse strandTRPT1NUDT22: 64,225,941–64,230,686, forward strandNUDT22DNAJC4: 64,230,158–64,234,286, forward strandVEGFB: 64,234,406–64,239,264, forward strandFKBP2: 64,241,003–64,244,583, forward strand: 64,241,095–64,244,583, forward strandPPP1R14B: 64,244,478–64,246,956, reverse strandPLCB3: 64,251,498–64,269,424, forward strandBAD: 64,269,828–64,291,946, reverse strandBADGPR137: 64,270,062–64,290,690, forward strandKCNK4: 64,291,302–64,300,031, forward strandKCNK4CATSPERZ: 64,300,338–64,304,770, forward strandCATSPERZESRRA: 64,305,080–64,317,859, forward strandTRMT112: 64,316,460–64,318,086, reverse strandPRDX5: 64,317,977–64,321,827, forward strandCCDC88B: 64,340,197–64,357,534, forward strandRPS6KA4: 64,359,134–64,372,215, forward strandRPS6KA4Diagram of MARK2: 19 exons on the forward strand of chromosome 11Exon 2: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 17: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 1: 63,839,110–63,839,560, 451 basesExon 2: 63,895,159–63,895,338, 180 basesExon 3: 63,895,580–63,895,633, 54 basesExon 4: 63,898,232–63,898,280, 49 basesExon 5: 63,898,608–63,898,673, 66 basesExon 6: 63,898,763–63,898,833, 71 basesExon 7: 63,899,052–63,899,108, 57 basesExon 8: 63,899,874–63,900,110, 237 basesExon 9: 63,900,559–63,900,678, 120 basesExon 10: 63,900,780–63,900,879, 100 basesExon 11: 63,900,957–63,901,069, 113 basesExon 12: 63,902,198–63,902,330, 133 basesExon 13: 63,902,601–63,902,782, 182 basesExon 14: 63,903,061–63,903,158, 98 basesExon 15: 63,903,986–63,904,147, 162 basesExon 16: 63,904,786–63,905,043, 258 basesExon 17: 63,906,088–63,906,114, 27 basesExon 18: 63,908,260–63,908,304, 45 basesExon 19: 63,908,877–63,911,020, 2,144 bases151015195′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.5 kb of the gene's 71.9 kb; 2,367 of those bases code for the protein.

How a genome test reads MARK2

8

positions in MARK2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 71.9 kb of MARK2, introns included, not only the 4.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MARK2 gene: microtubule affinity regulating kinase 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/mark2

Vancouver

Dante Labs. MARK2 gene: microtubule affinity regulating kinase 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/mark2

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