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Gene

SON

SON DNA and RNA binding protein

Summary

Cytogenetic location
21q22.11
Coordinates
Chromosome 21: 33,543,038–33,577,481 (GRCh38)
Exons
12 exons across 34.4 kb
Protein
2,426 amino acids
Also known as
DBP-5, NREBP, KIAA1019, BASS1, FLJ21099, FLJ33914
Previous symbols
C21orf50
MANE Select transcript
ENST00000356577.10NM_138927.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads SON yet. The test sequences your whole genome, so your data includes it all the same.

How SON is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 21, with a bracket where SON sits. SON and 14 genes near it on chromosome 21, from 33,060,260 to 34,060,259.Chromosome 2121q22.11p13p12p11.2p11.1q11.1q11.2q21.1q21.2q21.3q22.11q22.12q22.13q22.2q22.333.2 Mb33.4 Mb33.6 Mb33.8 Mb34 MbOLIG1: 33,070,141–33,072,413, forward strandOLIG1IFNAR2: 33,205,282–33,265,675, forward strandIFNAR2IFNAR2-IL10RB: 33,229,892–33,297,160, forward strandIFNAR2-IL10RBIL10RB: 33,265,958–33,311,420, forward strandIL10RBIFNAR1: 33,324,387–33,359,864, forward strandIFNAR1IFNGR2: 33,403,205–33,479,348, forward strandIFNGR2TMEM50B: 33,432,190–33,480,004, reverse strandTMEM50BDNAJC28: 33,485,615–33,491,753, reverse strandDNAJC28GART: 33,498,517–33,543,524, reverse strandGARTSON: 33,543,038–33,577,481, forward strandSONDONSON: 33,559,542–33,589,015, reverse strandDONSON: 33,584,687–33,931,607, reverse strandCRYZL1: 33,589,341–33,643,926, reverse strandCRYZL1ITSN1: 33,642,400–33,899,861, forward strandITSN1ATP5PO: 33,901,027–33,915,853, reverse strandATP5PODiagram of SON: 12 exons on the forward strand of chromosome 21Exon 2: 3 known disease-causing sitesExon 3: 63 known disease-causing sitesExon 4: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 1: 33,543,038–33,543,169, 132 basesExon 2: 33,546,213–33,546,379, 167 basesExon 3: 33,549,476–33,555,391, 5,916 basesExon 4: 33,557,156–33,557,316, 161 basesExon 5: 33,559,230–33,559,376, 147 basesExon 6: 33,559,587–33,559,775, 189 basesExon 7: 33,567,157–33,567,267, 111 basesExon 8: 33,568,971–33,569,087, 117 basesExon 9: 33,573,308–33,573,455, 148 basesExon 10: 33,575,596–33,575,667, 72 basesExon 11: 33,575,778–33,575,893, 116 basesExon 12: 33,576,365–33,577,481, 1,117 bases1246810125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8.4 kb of the gene's 34.4 kb; 7,281 of those bases code for the protein.

How a genome test reads SON

73

positions in SON where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (1.4%) falls in a region short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.

A whole genome covers all 34.4 kb of SON, introns included, not only the 8.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SON gene: SON DNA and RNA binding protein. Retrieved 16 October 2026, from https://dantelabs.com/genes/son

Vancouver

Dante Labs. SON gene: SON DNA and RNA binding protein [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/son

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