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Gene

SLC35C1

solute carrier family 35 member C1

Summary

Cytogenetic location
11p11.2
Coordinates
Chromosome 11: 45,805,149–45,813,016 (GRCh38)
Exons
2 exons across 7.9 kb
Protein
364 amino acids
Inheritance
Autosomal recessive
Also known as
FUCT1, FLJ11320
MANE Select transcript
ENST00000314134.4NM_018389.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Congenital Disorders of Glycosylation

    • SLC35C1-CDG (Leukocyte Adhesion Deficiency Type II)Autosomal recessive

      A congenital disorder of glycosylation caused by variants in the fucose transporter gene SLC35C1, with recurrent infections, very high white cell counts, growth and developmental delay.

      • ClinGen rates the link strong
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Oral fucose supplements can reduce infections in some people.

    • Congenital Disorders of Glycosylation (CDG)

      One of 98 genes linked to it

      A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

      • ClinGen rates the link strong
      • 5 GenCC submitters rate it definitive or strong

  • Leukocyte Adhesion Deficiency

    • Autosomal recessive

      Defective white cell adhesion caused by changes in both copies of ITGB2, SLC35C1 or FERMT3.

      • ClinGen rates the link strong
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Severe forms are treated with stem cell transplantation; type 2 may respond to oral fucose, and antibiotic prophylaxis and dental care reduce infections.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How SLC35C1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 11, with a bracket where SLC35C1 sits. SLC35C1 and 8 genes near it on chromosome 11, from 45,309,083 to 46,309,082.Chromosome 1111p11.2p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q2545.4 Mb45.6 Mb45.8 Mb46 Mb46.2 MbCHST1: 45,647,689–45,666,096, reverse strandCHST1SLC35C1: 45,805,149–45,813,016, forward strandSLC35C1CRY2: 45,847,118–45,883,248, forward strandCRY2MAPK8IP1: 45,885,593–45,906,470, forward strandMAPK8IP1FREY1: 45,906,513–45,907,272, reverse strandFREY1PEX16: 45,909,663–45,918,854, reverse strandPEX16LARGE2: 45,918,146–45,929,376, forward strandLARGE2PHF21A: 45,929,319–46,121,473, reverse strandCREB3L1: 46,277,636–46,321,422, forward strandCREB3L1Diagram of SLC35C1: 2 exons on the forward strand of chromosome 11Exon 1: 5 known disease-causing sitesExon 2: 3 known disease-causing sitesExon 1: 45,805,149–45,806,336, 1,188 basesExon 2: 45,810,776–45,813,016, 2,241 bases125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.4 kb of the gene's 7.9 kb; 1,095 of those bases code for the protein.

How a genome test reads SLC35C1

8

positions in SLC35C1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.9 kb of SLC35C1, introns included, not only the 3.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC35C1 gene: solute carrier family 35 member C1. Retrieved 16 October 2026, from https://dantelabs.com/genes/slc35c1

Vancouver

Dante Labs. SLC35C1 gene: solute carrier family 35 member C1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/slc35c1

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