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Gene

ADNP

activity dependent neuroprotector homeobox

Summary

Cytogenetic location
20q13.13
Coordinates
Chromosome 20: 50,888,918–50,931,437 (GRCh38)
Exons
6 exons across 42.5 kb
Protein
1,102 amino acids
Also known as
KIAA0784, ADNP1
MANE Select transcript
ENST00000621696.5NM_001282531.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 5 GenCC submitters rate it definitive or strong

    How ADNP is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 20, with a bracket where ADNP sits. ADNP and 8 genes near it on chromosome 20, from 50,410,178 to 51,410,177.Chromosome 2020q13.13p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3350.6 Mb50.8 Mb51 Mb51.2 Mb51.4 MbPTPN1: 50,510,321–50,585,241, forward strandPTPN1RIPOR3: 50,585,180–50,692,021, reverse strandRIPOR3PARD6B: 50,731,365–50,756,836, forward strandPARD6BBCAS4: 50,794,894–50,877,179, forward strandBCAS4ADNP: 50,888,918–50,931,437, reverse strandADNPDPM1: 50,932,897–50,959,145, reverse strandDPM1MOCS3: 50,958,818–50,963,929, forward strandMOCS3KCNG1: 51,003,655–51,023,244, reverse strandKCNG1NFATC2: 51,386,957–51,563,072, reverse strandNFATC2Diagram of ADNP: 6 exons on the reverse strand of chromosome 20Exon 6: 65 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 6: 50,888,918–50,894,512, 5,595 basesExon 5: 50,902,017–50,902,109, 93 basesExon 4: 50,903,889–50,904,001, 113 basesExon 3: 50,904,766–50,904,849, 84 basesExon 2: 50,928,651–50,928,825, 175 basesExon 1: 50,930,826–50,931,437, 612 bases6543215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 6.7 kb of the gene's 42.5 kb; 3,309 of those bases code for the protein.

    How a genome test reads ADNP

    73

    positions in ADNP where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 42.5 kb of ADNP, introns included, not only the 6.7 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). ADNP gene: activity dependent neuroprotector homeobox. Retrieved 17 October 2026, from https://dantelabs.com/genes/adnp

    Vancouver

    Dante Labs. ADNP gene: activity dependent neuroprotector homeobox [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/adnp

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