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Condition report · Immunological

Leukocyte Adhesion Deficiency

Inherited conditions in which white blood cells cannot stick to blood vessel walls and reach sites of infection, causing severe bacterial infections without pus, delayed separation of the umbilical cord and poor wound healing. Genes are ITGB2 (type 1), SLC35C1 (type 2) and FERMT3 (type 3, with bleeding).

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The condition we analyse

Leukocyte adhesion deficiency

Autosomal recessive

Defective white cell adhesion caused by changes in both copies of ITGB2, SLC35C1 or FERMT3.

What a diagnosis changes

Severe forms are treated with stem cell transplantation; type 2 may respond to oral fucose, and antibiotic prophylaxis and dental care reduce infections.

Genes analysed

Also known as

LAD

Includes 3 related subtypes ↓
  • leukocyte adhesion deficiency 1
  • leukocyte adhesion deficiency 3
  • leukocyte adhesion deficiency type II
MONDO:0017570Orphanet 2968MedGen 124419

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