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Gene

APC2

APC regulator of Wnt signaling pathway 2

Summary

Cytogenetic location
19p13.3
Coordinates
Chromosome 19: 1,450,121–1,473,244 (GRCh38)
Exons
15 exons across 23.1 kb
Protein
2,303 amino acids
Also known as
APCL
MANE Select transcript
ENST00000590469.6NM_005883.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads APC2 yet. The test sequences your whole genome, so your data includes it all the same.

How APC2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where APC2 sits. APC2 and 41 genes near it on chromosome 19, from 961,683 to 1,961,682.Chromosome 1919p13.3p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.431 Mb1.2 Mb1.4 Mb1.6 Mb1.8 MbARID3A: 924,528–975,939, forward strandARID3AWDR18: 984,248–998,438, forward strandWDR18GRIN3B: 1,000,419–1,009,732, forward strandGRIN3BTMEM259: 1,009,615–1,021,270, reverse strandTMEM259CNN2: 1,026,270–1,039,077, forward strandCNN2ABCA7: 1,039,997–1,065,572, forward strandABCA7ARHGAP45: 1,065,923–1,087,829, forward strandARHGAP45POLR2E: 1,085,104–1,095,486, reverse strandPOLR2EGPX4: 1,103,982–1,106,791, forward strandGPX4SBNO2: 1,107,634–1,174,295, reverse strandSBNO2STK11: 1,177,558–1,228,431, forward strandSTK11CBARP: 1,228,282–1,239,465, reverse strandATP5F1D: 1,241,734–1,244,828, forward strandMIDN: 1,248,316–1,259,145, forward strandCIRBP: 1,259,384–1,274,880, forward strandCIRBPFAM174C: 1,275,509–1,279,244, forward strandFAM174CFAM174C: 1,276,021–1,279,244, forward strandFAM174CEFNA2: 1,285,873–1,301,431, forward strandEFNA2PWWP3A: 1,354,293–1,378,434, forward strandPWWP3ANDUFS7: 1,383,527–1,395,590, forward strandNDUFS7GAMT: 1,397,026–1,401,731, reverse strandGAMTDAZAP1: 1,407,533–1,435,687, forward strandDAZAP1RPS15: 1,438,149–1,440,508, forward strandRPS15APC2: 1,450,121–1,473,244, forward strandAPC2C19orf25: 1,461,143–1,479,565, reverse strandC19orf25PCSK4: 1,481,428–1,490,752, reverse strandPCSK4REEP6: 1,491,016–1,497,928, forward strandREEP6ADAMTSL5: 1,503,045–1,513,604, reverse strandPLK5: 1,507,978–1,536,046, forward strandMEX3D: 1,554,672–1,568,352, reverse strandMEX3DMBD3: 1,573,596–1,592,911, reverse strandMBD3: 1,578,339–1,605,445, reverse strandUQCR11: 1,593,987–1,605,500, reverse strandUQCR11TCF3: 1,609,291–1,652,911, reverse strandTCF3ONECUT3: 1,753,506–1,780,988, forward strandONECUT3ATP8B3: 1,781,761–1,812,295, reverse strandATP8B3REXO1: 1,815,248–1,848,493, reverse strandREXO1KLF16: 1,852,399–1,863,919, reverse strandKLF16ABHD17A: 1,876,810–1,885,618, reverse strandABHD17AADAT3: 1,905,214–1,913,448, forward strandADAT3SCAMP4: 1,905,214–1,926,013, forward strandSCAMP4CSNK1G2: 1,940,915–1,981,339, forward strandCSNK1G2Diagram of APC2: 15 exons on the forward strand of chromosome 19Exon 4: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 14: 1 known disease-causing siteExon 15: 3 known disease-causing sitesExon 1: 1,450,121–1,450,338, 218 basesExon 2: 1,452,984–1,453,142, 159 basesExon 3: 1,453,247–1,453,337, 91 basesExon 4: 1,453,431–1,453,611, 181 basesExon 5: 1,455,149–1,455,257, 109 basesExon 6: 1,455,384–1,455,500, 117 basesExon 7: 1,456,076–1,456,153, 78 basesExon 8: 1,456,306–1,456,404, 99 basesExon 9: 1,456,853–1,457,243, 391 basesExon 10: 1,457,965–1,458,060, 96 basesExon 11: 1,460,181–1,460,320, 140 basesExon 12: 1,460,780–1,460,857, 78 basesExon 13: 1,461,037–1,461,153, 117 basesExon 14: 1,461,963–1,462,177, 215 basesExon 15: 1,465,155–1,473,244, 8,090 bases12468101214155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.2 kb of the gene's 23.1 kb; 6,912 of those bases code for the protein.

How a genome test reads APC2

8

positions in APC2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 23.1 kb of APC2, introns included, not only the 10.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). APC2 gene: APC regulator of Wnt signaling pathway 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/apc2

Vancouver

Dante Labs. APC2 gene: APC regulator of Wnt signaling pathway 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/apc2

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