Skip to content
Use your HSA or FSA funds

Gene

PIGT

phosphatidylinositol glycan anchor biosynthesis class T

Summary

Cytogenetic location
20q13.12
Coordinates
Chromosome 20: 45,416,141–45,426,241 (GRCh38)
Exons
12 exons across 10.1 kb
Protein
578 amino acids
Also known as
PIG-T
MANE Select transcript
ENST00000279036.12NM_015937.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • GPI Anchor Biosynthesis Defects

    • Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome

      A group of GPI anchor defects (PIGN, PIGA, PIGT, PIGQ and related genes) with low muscle tone, seizures, developmental delay and congenital anomalies.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
    • Disorders of GPI Anchor Biosynthesis

      A group of inherited conditions caused by variants in the PIG, PGAP and related genes needed to make and attach the GPI anchor, typically causing developmental delay, low muscle tone and epilepsy.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

Broader groupings

  • Congenital Disorders of Glycosylation

    • Congenital Disorders of Glycosylation (CDG)

      One of 98 genes linked to it

      A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

How PIGT is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 20, with a bracket where PIGT sits. PIGT and 41 genes near it on chromosome 20, from 44,921,191 to 45,921,190.Chromosome 2020q13.12p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3345 Mb45.2 Mb45.4 Mb45.6 Mb45.8 MbPABPC1L: 44,909,999–44,959,160, forward strandPABPC1LTOMM34: 44,942,130–44,960,449, reverse strandTOMM34STK4: 44,966,474–45,084,214, forward strandSTK4KCNS1: 45,091,214–45,101,188, reverse strandKCNS1WFDC5: 45,109,452–45,115,217, reverse strandWFDC5WFDC12: 45,123,425–45,124,465, reverse strandWFDC12PI3: 45,174,901–45,176,544, forward strandPI3SEMG1: 45,206,973–45,210,605, forward strandSEMG1SEMG2: 45,221,373–45,224,462, forward strandSEMG2SLPI: 45,251,638–45,254,568, reverse strandSLPIMATN4: 45,293,445–45,312,469, reverse strandMATN4RBPJL: 45,306,840–45,317,824, forward strandRBPJLSDC4: 45,325,288–45,348,433, reverse strandSDC4SYS1: 45,359,977–45,376,798, forward strandSYS1SYS1-DBNDD2: 45,363,200–45,410,610, forward strandSYS1-DBNDD2TP53TG5: 45,371,804–45,407,889, reverse strandTP53TG5DBNDD2: 45,405,616–45,410,870, forward strandDBNDD2PIGT: 45,416,141–45,426,241, forward strandPIGTWFDC2: 45,469,166–45,481,533, forward strandWFDC2SPINT3: 45,512,461–45,515,622, reverse strandSPINT3WFDC6: 45,533,091–45,539,496, reverse strandWFDC6EPPIN-WFDC6: 45,534,196–45,547,662, reverse strandEPPIN-WFDC6EPPIN: 45,540,626–45,547,786, reverse strandEPPINWFDC8: 45,551,153–45,579,326, reverse strandWFDC9: 45,607,939–45,631,284, reverse strandWFDC9WFDC10A: 45,629,733–45,631,196, forward strandWFDC10AWFDC11: 45,648,563–45,670,270, reverse strandWFDC11WFDC10B: 45,684,651–45,705,019, reverse strandWFDC10BWFDC13: 45,702,038–45,708,817, forward strandWFDC13SPINT4: 45,722,347–45,725,830, forward strandSPINT4WFDC3: 45,747,944–45,791,932, reverse strandWFDC3DNTTIP1: 45,791,937–45,811,427, forward strandDNTTIP1UBE2C: 45,812,561–45,816,965, forward strandUBE2CTNNC2: 45,823,214–45,833,745, reverse strandTNNC2SNX21: 45,833,633–45,843,276, forward strandSNX21ACOT8: 45,841,709–45,857,435, reverse strandZSWIM3: 45,857,591–45,879,131, forward strandZSWIM1: 45,881,201–45,885,266, forward strandZSWIM1SPATA25: 45,886,491–45,887,626, reverse strandNEURL2: 45,888,002–45,891,220, reverse strandCTSA: 45,890,144–45,898,949, forward strandCTSAPLTP: 45,897,535–45,912,235, reverse strandDiagram of PIGT: 12 exons on the forward strand of chromosome 20Exon 1: 3 known disease-causing sitesExon 2: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 4: 4 known disease-causing sitesExon 6: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 9: 2 known disease-causing sitesExon 10: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 12: 2 known disease-causing sitesExon 1: 45,416,141–45,416,343, 203 basesExon 2: 45,416,517–45,416,694, 178 basesExon 3: 45,418,852–45,418,979, 128 basesExon 4: 45,419,295–45,419,395, 101 basesExon 5: 45,419,504–45,419,590, 87 basesExon 6: 45,420,136–45,420,223, 88 basesExon 7: 45,420,332–45,420,429, 98 basesExon 8: 45,420,528–45,420,693, 166 basesExon 9: 45,421,383–45,421,583, 201 basesExon 10: 45,424,216–45,424,381, 166 basesExon 11: 45,424,496–45,424,579, 84 basesExon 12: 45,425,574–45,426,241, 668 bases1234567891011125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 10.1 kb; 1,737 of those bases code for the protein.

How a genome test reads PIGT

23

positions in PIGT where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 10.1 kb of PIGT, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PIGT gene: phosphatidylinositol glycan anchor biosynthesis class T. Retrieved 16 October 2026, from https://dantelabs.com/genes/pigt

Vancouver

Dante Labs. PIGT gene: phosphatidylinositol glycan anchor biosynthesis class T [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/pigt

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test