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Gene

FRAS1

Fraser extracellular matrix complex subunit 1

Summary

Cytogenetic location
4q21.21
Coordinates
Chromosome 4: 78,057,323–78,544,269 (GRCh38)
Exons
74 exons across 486.9 kb
Protein
4,012 amino acids
Also known as
FLJ22031, FLJ14927, KIAA1500
MANE Select transcript
ENST00000512123.4NM_025074.7
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads FRAS1 yet. The test sequences your whole genome, so your data includes it all the same.

How FRAS1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where FRAS1 sits. FRAS1 and 6 genes near it on chromosome 4, from 77,570,376 to 79,031,216.Chromosome 44q21.21p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.277.6 Mb77.8 Mb78 Mb78.2 Mb78.4 Mb78.6 Mb78.8 Mb79 MbCXCL13: 77,511,753–77,611,834, forward strandCXCL13CNOT6L: 77,713,387–77,819,615, reverse strandCNOT6LMRPL1: 77,862,139–77,952,791, forward strandMRPL1FRAS1: 78,057,323–78,544,269, forward strandFRAS1ANXA3: 78,551,615–78,611,402, forward strandANXA3BMP2K: 78,776,015–78,916,365, forward strandBMP2KPAQR3: 78,887,127–78,939,440, reverse strandPAQR3Diagram of FRAS1: 74 exons on the forward strand of chromosome 4Exon 1: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 5: 6 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 7: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 12: 5 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 14: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 17: 3 known disease-causing sitesExon 18: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 20: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 22: 2 known disease-causing sitesExon 23: 1 known disease-causing siteExon 24: 1 known disease-causing siteExon 26: 1 known disease-causing siteExon 28: 3 known disease-causing sitesExon 29: 3 known disease-causing sitesExon 30: 3 known disease-causing sitesExon 31: 2 known disease-causing sitesExon 34: 1 known disease-causing siteExon 37: 1 known disease-causing siteExon 38: 4 known disease-causing sitesExon 39: 3 known disease-causing sitesExon 40: 2 known disease-causing sitesExon 41: 1 known disease-causing siteExon 42: 4 known disease-causing sitesExon 43: 4 known disease-causing sitesExon 44: 2 known disease-causing sitesExon 45: 3 known disease-causing sitesExon 46: 1 known disease-causing siteExon 47: 1 known disease-causing siteExon 48: 1 known disease-causing siteExon 49: 1 known disease-causing siteExon 50: 3 known disease-causing sitesExon 52: 1 known disease-causing siteExon 53: 2 known disease-causing sitesExon 54: 1 known disease-causing siteExon 55: 1 known disease-causing siteExon 56: 1 known disease-causing siteExon 57: 1 known disease-causing siteExon 59: 1 known disease-causing siteExon 60: 1 known disease-causing siteExon 61: 3 known disease-causing sitesExon 62: 1 known disease-causing siteExon 63: 3 known disease-causing sitesExon 64: 1 known disease-causing siteExon 66: 1 known disease-causing siteExon 70: 2 known disease-causing sitesExon 71: 3 known disease-causing sitesExon 72: 3 known disease-causing sitesExon 74: 4 known disease-causing sitesExon 1: 78,057,323–78,058,085, 763 basesExon 2: 78,065,985–78,066,016, 32 basesExon 3: 78,237,510–78,237,617, 108 basesExon 4: 78,245,233–78,245,325, 93 basesExon 5: 78,252,392–78,252,551, 160 basesExon 6: 78,255,242–78,255,375, 134 basesExon 7: 78,265,025–78,265,108, 84 basesExon 8: 78,266,834–78,266,935, 102 basesExon 9: 78,267,241–78,267,432, 192 basesExon 10: 78,278,655–78,278,744, 90 basesExon 11: 78,281,398–78,281,433, 36 basesExon 12: 78,282,820–78,282,967, 148 basesExon 13: 78,284,405–78,284,548, 144 basesExon 14: 78,286,405–78,286,539, 135 basesExon 15: 78,308,066–78,308,209, 144 basesExon 16: 78,315,594–78,315,734, 141 basesExon 17: 78,317,368–78,317,508, 141 basesExon 18: 78,318,810–78,318,986, 177 basesExon 19: 78,333,272–78,333,412, 141 basesExon 20: 78,337,674–78,337,817, 144 basesExon 21: 78,363,513–78,363,665, 153 basesExon 22: 78,363,908–78,364,054, 147 basesExon 23: 78,369,838–78,369,984, 147 basesExon 24: 78,372,718–78,372,858, 141 basesExon 25: 78,374,111–78,374,251, 141 basesExon 26: 78,375,739–78,375,879, 141 basesExon 27: 78,379,726–78,379,996, 271 basesExon 28: 78,384,059–78,384,143, 85 basesExon 29: 78,387,375–78,387,701, 327 basesExon 30: 78,400,734–78,400,887, 154 basesExon 31: 78,407,663–78,407,841, 179 basesExon 32: 78,412,969–78,413,085, 117 basesExon 33: 78,418,949–78,419,063, 115 basesExon 34: 78,421,863–78,422,000, 138 basesExon 35: 78,424,388–78,424,420, 33 basesExon 36: 78,429,095–78,429,226, 132 basesExon 37: 78,430,292–78,430,417, 126 basesExon 38: 78,432,357–78,432,604, 248 basesExon 39: 78,438,570–78,438,718, 149 basesExon 40: 78,438,902–78,439,064, 163 basesExon 41: 78,441,162–78,441,297, 136 basesExon 42: 78,445,522–78,445,712, 191 basesExon 43: 78,446,727–78,446,880, 154 basesExon 44: 78,448,053–78,448,316, 264 basesExon 45: 78,450,151–78,450,339, 189 basesExon 46: 78,451,772–78,451,891, 120 basesExon 47: 78,452,175–78,452,354, 180 basesExon 48: 78,464,021–78,464,145, 125 basesExon 49: 78,464,443–78,464,583, 141 basesExon 50: 78,466,208–78,466,435, 228 basesExon 51: 78,469,978–78,470,091, 114 basesExon 52: 78,472,180–78,472,330, 151 basesExon 53: 78,473,438–78,473,597, 160 basesExon 54: 78,475,438–78,475,606, 169 basesExon 55: 78,477,815–78,478,061, 247 basesExon 56: 78,479,374–78,479,718, 345 basesExon 57: 78,481,804–78,481,964, 161 basesExon 58: 78,482,388–78,482,535, 148 basesExon 59: 78,488,875–78,489,080, 206 basesExon 60: 78,496,805–78,496,961, 157 basesExon 61: 78,499,721–78,499,921, 201 basesExon 62: 78,507,421–78,507,608, 188 basesExon 63: 78,508,731–78,509,006, 276 basesExon 64: 78,511,274–78,511,506, 233 basesExon 65: 78,513,392–78,513,552, 161 basesExon 66: 78,515,799–78,516,013, 215 basesExon 67: 78,519,331–78,519,481, 151 basesExon 68: 78,521,523–78,521,630, 108 basesExon 69: 78,522,649–78,522,808, 160 basesExon 70: 78,526,541–78,526,657, 117 basesExon 71: 78,534,449–78,534,615, 167 basesExon 72: 78,536,995–78,537,200, 206 basesExon 73: 78,539,294–78,539,440, 147 basesExon 74: 78,540,531–78,544,269, 3,739 bases1510152025303540455055606570745′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 15.9 kb of the gene's 486.9 kb; 12,039 of those bases code for the protein.

How a genome test reads FRAS1

151

positions in FRAS1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 486.9 kb of FRAS1, introns included, not only the 15.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). FRAS1 gene: Fraser extracellular matrix complex subunit 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/fras1

Vancouver

Dante Labs. FRAS1 gene: Fraser extracellular matrix complex subunit 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fras1

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