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Gene

HIRA

histone cell cycle regulator

Summary

Cytogenetic location
22q11.21
Coordinates
Chromosome 22: 19,330,698–19,431,733 (GRCh38)
Exons
25 exons across 101 kb
Protein
1,017 amino acids
Also known as
DGCR1, TUP1
Previous symbols
TUPLE1
MANE Select transcript
ENST00000263208.5NM_003325.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads HIRA yet. The test sequences your whole genome, so your data includes it all the same.

How HIRA is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 22, with a bracket where HIRA sits. HIRA and 22 genes near it on chromosome 22, from 18,881,216 to 19,881,215.Chromosome 2222q11.21p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3319 Mb19.2 Mb19.4 Mb19.6 Mb19.8 MbDGCR6: 18,905,677–18,916,623, forward strandDGCR6: 18,906,238–18,947,732, forward strandPRODH: 18,912,696–18,936,451, reverse strandPRODHFAM246C: 19,029,524–19,031,242, forward strandFAM246CDGCR2: 19,036,280–19,122,461, reverse strandDGCR2ESS2: 19,130,279–19,144,684, reverse strandESS2TSSK2: 19,131,308–19,132,622, forward strandTSSK2GSC2: 19,146,993–19,150,292, reverse strandGSC2SLC25A1: 19,175,573–19,178,863, reverse strandSLC25A1CLTCL1: 19,179,319–19,291,774, reverse strandCLTCL1HIRA: 19,330,698–19,431,733, reverse strandHIRAC22orf39: 19,351,368–19,447,714, reverse strandC22orf39MRPL40: 19,431,837–19,436,078, forward strandMRPL40UFD1: 19,449,899–19,479,695, reverse strandUFD1CDC45: 19,479,457–19,520,612, forward strandCDC45CLDN5: 19,517,452–19,527,545, reverse strandCLDN5SEPTIN5: 19,714,117–19,724,781, forward strandSEPTIN5: 19,717,220–19,724,772, forward strandGP1BB: 19,723,539–19,724,776, forward strandGP1BBTBX1: 19,756,703–19,783,593, forward strandTBX1GNB1L: 19,781,243–19,854,947, reverse strandGNB1LRTL10: 19,846,138–19,854,939, reverse strandRTL10TXNRD2: 19,875,517–19,941,934, reverse strandTXNRD2Diagram of HIRA: 25 exons on the reverse strand of chromosome 22Exon 25: 19,330,698–19,331,556, 859 basesExon 24: 19,351,358–19,351,446, 89 basesExon 23: 19,353,356–19,353,519, 164 basesExon 22: 19,353,996–19,354,118, 123 basesExon 21: 19,355,760–19,355,865, 106 basesExon 20: 19,356,230–19,356,288, 59 basesExon 19: 19,356,890–19,357,051, 162 basesExon 18: 19,359,336–19,359,484, 149 basesExon 17: 19,361,237–19,361,341, 105 basesExon 16: 19,361,727–19,361,931, 205 basesExon 15: 19,375,631–19,375,792, 162 basesExon 14: 19,377,869–19,378,066, 198 basesExon 13: 19,383,620–19,383,705, 86 basesExon 12: 19,385,521–19,385,736, 216 basesExon 11: 19,387,711–19,387,816, 106 basesExon 10: 19,388,484–19,388,554, 71 basesExon 9: 19,392,101–19,392,214, 114 basesExon 8: 19,394,342–19,394,509, 168 basesExon 7: 19,396,787–19,396,947, 161 basesExon 6: 19,397,992–19,398,087, 96 basesExon 5: 19,405,786–19,405,880, 95 basesExon 4: 19,407,184–19,407,274, 91 basesExon 3: 19,408,483–19,408,593, 111 basesExon 2: 19,410,716–19,410,778, 63 basesExon 1: 19,431,440–19,431,733, 294 bases25201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.1 kb of the gene's 101 kb; 3,054 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). HIRA gene: histone cell cycle regulator. Retrieved 16 October 2026, from https://dantelabs.com/genes/hira

Vancouver

Dante Labs. HIRA gene: histone cell cycle regulator [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/hira

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