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Gene

SNAI2

snail family transcriptional repressor 2

Summary

Cytogenetic location
8q11.21
Coordinates
Chromosome 8: 48,917,598–48,921,429 (GRCh38)
Exons
3 exons across 3.8 kb
Protein
268 amino acids
Also known as
SLUGH1, SNAIL2, SLUGH
Previous symbols
SLUG
MANE Select transcript
ENST00000020945.4NM_003068.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Waardenburg Syndrome

    • A group of conditions (types 1 to 4) causing hearing loss and pigment changes of the hair, skin and eyes, caused by genes such as PAX3, MITF, SOX10, EDNRB and EDN3.

      • 1 GenCC submitter rates it definitive or strong

How SNAI2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 8, with a bracket where SNAI2 sits. SNAI2 and 2 genes near it on chromosome 8, from 48,419,514 to 49,419,513.Chromosome 88q11.21p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.348.6 Mb48.8 Mb49 Mb49.2 Mb49.4 MbCLXN: 48,710,789–48,735,311, reverse strandCLXNSNAI2: 48,917,598–48,921,429, reverse strandSNAI2PPDPFL: 49,054,311–49,076,093, forward strandPPDPFLDiagram of SNAI2: 3 exons on the reverse strand of chromosome 8Exon 3: 48,917,598–48,918,988, 1,391 basesExon 2: 48,919,896–48,920,441, 546 basesExon 1: 48,921,187–48,921,429, 243 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 3.8 kb; 807 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SNAI2 gene: snail family transcriptional repressor 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/snai2

Vancouver

Dante Labs. SNAI2 gene: snail family transcriptional repressor 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/snai2

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