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Gene

KIF11

kinesin family member 11

Summary

Cytogenetic location
10q23.33
Coordinates
Chromosome 10: 92,593,130–92,655,395 (GRCh38)
Exons
22 exons across 62.3 kb
Protein
1,056 amino acids
Inheritance
Autosomal dominant
Also known as
Eg5, HKSP, TRIP5
Previous symbols
KNSL1
MANE Select transcript
ENST00000260731.5NM_004523.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Lymphoedema & Lymphatic Malformations

    • Microcephaly with Chorioretinopathy, Lymphoedema or Intellectual DisabilityAutosomal dominant

      A condition caused by changes in KIF11 with variable small head size, eye changes, leg lymphoedema and learning difficulties.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How KIF11 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where KIF11 sits. KIF11 and 7 genes near it on chromosome 10, from 92,124,263 to 93,124,262.Chromosome 1010q23.33p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.392.2 Mb92.4 Mb92.6 Mb92.8 Mb93 MbCPEB3: 92,046,692–92,291,628, reverse strandCPEB3MARCHF5: 92,291,142–92,354,079, forward strandMARCHF5IDE: 92,451,684–92,574,096, reverse strandIDEKIF11: 92,593,130–92,655,395, forward strandKIF11HHEX: 92,689,893–92,695,647, forward strandHHEXEXOC6: 92,826,831–93,059,493, forward strandEXOC6CYP26C1: 93,060,798–93,069,540, forward strandCYP26C1CYP26A1: 93,073,475–93,077,885, forward strandCYP26A1Diagram of KIF11: 22 exons on the forward strand of chromosome 10Exon 1: 2 known disease-causing sitesExon 2: 4 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 4: 1 known disease-causing siteExon 5: 6 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 7: 1 known disease-causing siteExon 8: 5 known disease-causing sitesExon 9: 3 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 11: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 13: 5 known disease-causing sitesExon 14: 1 known disease-causing siteExon 15: 1 known disease-causing siteExon 16: 3 known disease-causing sitesExon 17: 2 known disease-causing sitesExon 18: 5 known disease-causing sitesExon 19: 5 known disease-causing sitesExon 20: 3 known disease-causing sitesExon 21: 1 known disease-causing siteExon 1: 92,593,130–92,593,452, 323 basesExon 2: 92,606,265–92,606,397, 133 basesExon 3: 92,606,619–92,606,716, 98 basesExon 4: 92,607,159–92,607,237, 79 basesExon 5: 92,609,020–92,609,205, 186 basesExon 6: 92,609,385–92,609,509, 125 basesExon 7: 92,613,040–92,613,130, 91 basesExon 8: 92,613,377–92,613,619, 243 basesExon 9: 92,616,737–92,616,832, 96 basesExon 10: 92,621,385–92,621,473, 89 basesExon 11: 92,628,808–92,628,895, 88 basesExon 12: 92,630,176–92,630,364, 189 basesExon 13: 92,632,486–92,632,693, 208 basesExon 14: 92,633,623–92,633,795, 173 basesExon 15: 92,637,184–92,637,309, 126 basesExon 16: 92,637,387–92,637,545, 159 basesExon 17: 92,639,794–92,639,900, 107 basesExon 18: 92,645,363–92,645,642, 280 basesExon 19: 92,648,212–92,648,434, 223 basesExon 20: 92,649,835–92,649,986, 152 basesExon 21: 92,650,401–92,650,517, 117 basesExon 22: 92,653,665–92,655,395, 1,731 bases15101520225′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5 kb of the gene's 62.3 kb; 3,171 of those bases code for the protein.

How a genome test reads KIF11

72

positions in KIF11 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 62.3 kb of KIF11, introns included, not only the 5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KIF11 gene: kinesin family member 11. Retrieved 17 October 2026, from https://dantelabs.com/genes/kif11

Vancouver

Dante Labs. KIF11 gene: kinesin family member 11 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/kif11

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