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Gene

TFAP2A

transcription factor AP-2 alpha

Summary

Cytogenetic location
6p24.3
Coordinates
Chromosome 6: 10,396,677–10,415,074 (GRCh38)
Exons
7 exons across 18.4 kb
Protein
439 amino acids
Also known as
AP-2, AP-2alpha
Previous symbols
TFAP2, AP2TF
MANE Select transcript
ENST00000379613.10NM_001372066.1
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TFAP2A yet. The test sequences your whole genome, so your data includes it all the same.

How TFAP2A is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 6, with a bracket where TFAP2A sits. TFAP2A and 9 genes near it on chromosome 6, from 9,905,876 to 10,905,875.Chromosome 66p24.3p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2710 Mb10.2 Mb10.4 Mb10.6 Mb10.8 MbTFAP2A: 10,396,677–10,415,074, reverse strandTFAP2AGCNT2: 10,492,223–10,629,377, forward strandGCNT2C6orf52: 10,671,283–10,694,797, reverse strandC6orf52PAK1IP1: 10,694,633–10,711,168, forward strandPAK1IP1TMEM14C: 10,722,915–10,731,141, forward strandTMEM14CTMEM14B: 10,747,695–10,866,590, forward strandTMEM14B: 10,747,794–10,930,423, forward strandMAK: 10,762,723–10,838,553, reverse strandMAKGCM2: 10,873,223–10,882,041, reverse strandGCM2SYCP2L: 10,886,831–10,979,320, forward strandSYCP2LDiagram of TFAP2A: 7 exons on the reverse strand of chromosome 6Exon 7: 4 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 5: 4 known disease-causing sitesExon 4: 17 known disease-causing sitesExon 2: 5 known disease-causing sitesExon 7: 10,396,677–10,398,705, 2,029 basesExon 6: 10,400,448–10,400,589, 142 basesExon 5: 10,402,492–10,402,610, 119 basesExon 4: 10,404,508–10,404,739, 232 basesExon 3: 10,406,793–10,406,844, 52 basesExon 2: 10,409,901–10,410,335, 435 basesExon 1: 10,414,941–10,415,074, 134 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.1 kb of the gene's 18.4 kb; 1,320 of those bases code for the protein.

How a genome test reads TFAP2A

36

positions in TFAP2A where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.4 kb of TFAP2A, introns included, not only the 3.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TFAP2A gene: transcription factor AP-2 alpha. Retrieved 17 October 2026, from https://dantelabs.com/genes/tfap2a

Vancouver

Dante Labs. TFAP2A gene: transcription factor AP-2 alpha [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tfap2a

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