Skip to content
Use your HSA or FSA funds

Gene

RIN2

Ras and Rab interactor 2

Summary

Cytogenetic location
20p11.23
Coordinates
Chromosome 20: 19,758,258–20,002,456 (GRCh38)
Exons
13 exons across 244.2 kb
Protein
895 amino acids
Also known as
RASSF4
MANE Select transcript
ENST00000255006.12NM_018993.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Cutis Laxa

    • Cutis laxa (CL) is an inherited or acquired connective tissue disorder characterized by wrinkled, redundant and sagging inelastic skin associated with skeletal and developmental anomalies and, in some cases, with severe systemic involvement. Several different forms of inherited CL have been described, differentiated on the basis of the mode of inheritance and differences in the extent of internal organ involvement, associated anomalies and disease severity.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

How RIN2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 20, with a bracket where RIN2 sits. RIN2 and 5 genes near it on chromosome 20, from 19,380,357 to 20,380,356.Chromosome 2020p11.23p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3319.4 Mb19.6 Mb19.8 Mb20 Mb20.2 MbSLC24A3: 19,212,495–19,724,784, forward strandSLC24A3RIN2: 19,758,258–20,002,456, forward strandRIN2NAA20: 20,017,310–20,034,387, forward strandNAA20CRNKL1: 20,027,769–20,056,046, reverse strandCRNKL1CFAP61: 20,052,511–20,360,703, forward strandCFAP61INSM1: 20,368,104–20,370,949, forward strandINSM1Diagram of RIN2: 13 exons on the forward strand of chromosome 20Exon 5: 1 known disease-causing siteExon 11: 1 known disease-causing siteExon 1: 19,758,258–19,758,327, 70 basesExon 2: 19,799,622–19,799,747, 126 basesExon 3: 19,889,566–19,889,658, 93 basesExon 4: 19,935,099–19,935,199, 101 basesExon 5: 19,956,615–19,956,807, 193 basesExon 6: 19,960,700–19,960,811, 112 basesExon 7: 19,964,952–19,965,024, 73 basesExon 8: 19,970,838–19,970,929, 92 basesExon 9: 19,974,654–19,975,787, 1,134 basesExon 10: 19,990,006–19,990,311, 306 basesExon 11: 19,992,168–19,992,299, 132 basesExon 12: 19,996,679–19,996,842, 164 basesExon 13: 20,000,613–20,002,456, 1,844 bases1510135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.4 kb of the gene's 244.2 kb; 2,688 of those bases code for the protein.

How a genome test reads RIN2

2

positions in RIN2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 244.2 kb of RIN2, introns included, not only the 4.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RIN2 gene: Ras and Rab interactor 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/rin2

Vancouver

Dante Labs. RIN2 gene: Ras and Rab interactor 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/rin2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test