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Gene

AGO2

argonaute RISC catalytic component 2

Summary

Cytogenetic location
8q24.3
Coordinates
Chromosome 8: 140,520,156–140,635,633 (GRCh38)
Exons
19 exons across 115.5 kb
Protein
859 amino acids
Also known as
hAGO2, Q10, LINC00980
Previous symbols
EIF2C2, CASC7
MANE Select transcript
ENST00000220592.10NM_012154.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads AGO2 yet. The test sequences your whole genome, so your data includes it all the same.

How AGO2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where AGO2 sits. AGO2 and 3 genes near it on chromosome 8, from 140,077,895 to 141,077,894.Chromosome 88q24.3p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.3140.2 Mb140.4 Mb140.6 Mb140.8 Mb141 MbTRAPPC9: 139,726,939–140,458,579, reverse strandTRAPPC9CHRAC1: 140,511,288–140,517,154, forward strandCHRAC1AGO2: 140,520,156–140,635,633, reverse strandAGO2PTK2: 140,657,900–141,002,216, reverse strandPTK2Diagram of AGO2: 19 exons on the reverse strand of chromosome 8Exon 18: 1 known disease-causing siteExon 14: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 9: 3 known disease-causing sitesExon 8: 1 known disease-causing siteExon 5: 3 known disease-causing sitesExon 19: 140,520,156–140,532,152, 11,997 basesExon 18: 140,532,416–140,532,615, 200 basesExon 17: 140,535,468–140,535,569, 102 basesExon 16: 140,539,320–140,539,454, 135 basesExon 15: 140,541,164–140,541,358, 195 basesExon 14: 140,544,213–140,544,303, 91 basesExon 13: 140,547,468–140,547,627, 160 basesExon 12: 140,549,114–140,549,298, 185 basesExon 11: 140,551,303–140,551,436, 134 basesExon 10: 140,555,896–140,556,018, 123 basesExon 9: 140,556,167–140,556,286, 120 basesExon 8: 140,557,089–140,557,236, 148 basesExon 7: 140,558,485–140,558,572, 88 basesExon 6: 140,559,395–140,559,529, 135 basesExon 5: 140,560,374–140,560,510, 137 basesExon 4: 140,562,453–140,562,634, 182 basesExon 3: 140,572,812–140,572,932, 121 basesExon 2: 140,585,119–140,585,311, 193 basesExon 1: 140,635,485–140,635,633, 149 bases191510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 14.6 kb of the gene's 115.5 kb; 2,580 of those bases code for the protein.

How a genome test reads AGO2

10

positions in AGO2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 115.5 kb of AGO2, introns included, not only the 14.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AGO2 gene: argonaute RISC catalytic component 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/ago2

Vancouver

Dante Labs. AGO2 gene: argonaute RISC catalytic component 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ago2

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