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Gene

GLUL

glutamate-ammonia ligase

Summary

Cytogenetic location
1q25.3
Coordinates
Chromosome 1: 182,378,098–182,391,790 (GRCh38)
Exons
7 exons across 13.7 kb
Protein
373 amino acids
Previous symbols
GLNS
MANE Select transcript
ENST00000331872.11NM_001033044.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • ClinGen rates the link moderate
        • 2 GenCC submitters rate it definitive or strong

    How GLUL is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 1, with a bracket where GLUL sits. GLUL and 8 genes near it on chromosome 1, from 181,884,944 to 182,884,943.Chromosome 11q25.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44182 Mb182.2 Mb182.4 Mb182.6 Mb182.8 MbZNF648: 182,054,570–182,061,712, reverse strandZNF648GLUL: 182,378,098–182,391,790, reverse strandGLULTEDDM1: 182,398,117–182,400,667, reverse strandTEDDM1RGSL1: 182,409,192–182,560,599, forward strandRGSL1RNASEL: 182,563,015–182,589,272, reverse strandRNASELRGS16: 182,598,623–182,604,394, reverse strandRGS16RGS8: 182,641,816–182,684,587, reverse strandRGS8NPL: 182,789,263–182,831,017, forward strandNPLDHX9: 182,839,302–182,888,120, forward strandDHX9Diagram of GLUL: 7 exons on the reverse strand of chromosome 1Exon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 7: 182,378,098–182,384,723, 6,626 basesExon 6: 182,385,357–182,385,556, 200 basesExon 5: 182,385,760–182,385,887, 128 basesExon 4: 182,386,256–182,386,402, 147 basesExon 3: 182,387,131–182,387,292, 162 basesExon 2: 182,388,572–182,388,750, 179 basesExon 1: 182,391,679–182,391,790, 112 bases76543215′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 7.6 kb of the gene's 13.7 kb; 1,122 of those bases code for the protein.

    How a genome test reads GLUL

    8

    positions in GLUL where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 13.7 kb of GLUL, introns included, not only the 7.6 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). GLUL gene: glutamate-ammonia ligase. Retrieved 16 October 2026, from https://dantelabs.com/genes/glul

    Vancouver

    Dante Labs. GLUL gene: glutamate-ammonia ligase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/glul

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