Gene

CENPF

centromere protein F

Cytogenetic location: 1q41
Coordinates: Chromosome 1: 214,603,195–214,664,571 (GRCh38)
Exons: 20 exons across 61.4 kb
Protein: 3,114 amino acids
Also known as: hcp-1
MANE Select transcript: ENST00000366955.8NM_016343.4
Locus type: Protein-coding

This page as data

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Curated report relevant to this gene

Primary Ciliary Dyskinesia
- Autosomal recessive
  A rare, genetically heterogeneous, primarily respiratory disorder characterized by chronic upper and lower respiratory tract disease. Approximately half of PCD patients have an organ laterality defect (situs inversus totalis or situs ambiguus/heterotaxy).
  - 4 GenCC submitters rate it definitive or strong

How CENPF is laid out

Coding sequence
Untranslated region
Intron
Direction of transcription
Known disease-causing sites
Stretches short reads find hard

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 10.3 kb of the gene's 61.4 kb; 9,345 of those bases code for the protein.

Sequencing CENPF

positions in CENPF where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 61.4 kb of CENPF, introns included, not only the 10.3 kb of exons.

Traits linked to CENPF

The Human Phenotype Ontology lists these as features of the rare conditions CENPF can cause. Each trait's page lists the other genes linked to it.

Abnormality of the eye

Show 1 more trait

Wide-set eyes

Abnormality of head or neck

Abnormality of the nervous system

Abnormality of the digestive system

Abnormality of the cardiovascular system

Abnormality of the genitourinary system

External links

Gene records

Transcript

Protein

Variants

Clinical

Where this comes from

HGNC: the gene's symbol, name, other symbols and location.
MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
The ACMG secondary findings list, SF v3.2.
ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). CENPF gene: centromere protein F. Retrieved 17 October 2026, from https://dantelabs.com/genes/cenpf

Vancouver

Dante Labs. CENPF gene: centromere protein F [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cenpf

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