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Gene

RPL10

ribosomal protein L10

Summary

Cytogenetic location
Xq28
Coordinates
Chromosome X: 154,398,377–154,402,332 (GRCh38)
Exons
7 exons across 4 kb
Protein
214 amino acids
Also known as
NOV, QM, DXS648E, DXS648, FLJ23544, L10, uL16
MANE Select transcript
ENST00000369817.7NM_006013.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong

    How RPL10 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome X, with a bracket where RPL10 sits. RPL10 and 39 genes near it on chromosome X, from 153,900,355 to 154,900,354.Chromosome XXq28p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q28154 Mb154.2 Mb154.4 Mb154.6 Mb154.8 Mb: 153,872,221–153,909,223, reverse strandAVPR2: 153,902,531–153,907,169, forward strandAVPR2ARHGAP4: 153,907,367–153,934,999, reverse strandNAA10: 153,928,799–153,935,083, reverse strandNAA10RENBP: 153,935,269–153,944,688, reverse strandRENBPHCFC1: 153,946,434–153,972,427, reverse strandHCFC1TMEM187: 153,972,290–153,983,194, forward strandTMEM187IRAK1: 154,010,501–154,020,650, reverse strandIRAK1MECP2: 154,021,573–154,137,103, reverse strandMECP2OPN1LW: 154,144,243–154,159,032, forward strandOPN1LWOPN1MW: 154,182,596–154,196,861, forward strandOPN1MWOPN1MW2: 154,219,756–154,233,286, forward strandOPN1MW2OPN1MW3: 154,257,582–154,271,090, forward strandOPN1MW3TEX28: 154,271,265–154,295,853, reverse strandTEX28TKTL1: 154,295,795–154,330,350, forward strandTKTL1FLNA: 154,348,524–154,374,643, reverse strandEMD: 154,379,205–154,381,574, forward strandEMDRPL10: 154,398,377–154,402,332, forward strandRPL10DNASE1L1: 154,401,236–154,412,119, reverse strandDNASE1L1TAFAZZIN: 154,409,456–154,421,726, forward strandTAFAZZINATP6AP1: 154,428,618–154,436,517, forward strandGDI1: 154,436,600–154,443,467, forward strandGDI1FAM50A: 154,444,103–154,450,655, forward strandPLXNA3: 154,458,275–154,477,779, forward strandLAGE3: 154,477,598–154,479,291, reverse strandLAGE3UBL4A: 154,483,717–154,486,661, reverse strandUBL4ASLC10A3: 154,487,306–154,490,690, reverse strandFAM3A: 154,505,019–154,516,882, reverse strandFAM3AG6PD: 154,517,825–154,547,584, reverse strandG6PDIKBKG: 154,541,179–154,568,543, forward strandIKBKGCTAG1A: 154,585,133–154,586,816, forward strandCTAG1ACTAG1B: 154,617,609–154,619,282, reverse strandCTAG1BCTAG2: 154,651,972–154,653,579, reverse strandCTAG2GAB3: 154,675,249–154,751,583, reverse strandGAB3DKC1: 154,762,741–154,777,697, forward strandDKC1MPP1: 154,778,684–154,821,039, reverse strandMPP1SMIM9: 154,823,348–154,834,662, reverse strandSMIM9F8: 154,835,788–155,026,940, reverse strandF8H2AB1: 154,884,972–154,885,558, forward strandH2AB1F8A1: 154,886,355–154,888,061, forward strandF8A1Diagram of RPL10: 7 exons on the forward strand of chromosome XExon 7: 1 known disease-causing siteExon 1: 154,398,377–154,398,394, 18 basesExon 2: 154,398,497–154,398,542, 46 basesExon 3: 154,399,338–154,399,396, 59 basesExon 4: 154,399,487–154,399,594, 108 basesExon 5: 154,399,803–154,399,941, 139 basesExon 6: 154,400,464–154,400,626, 163 basesExon 7: 154,400,702–154,402,332, 1,631 bases12345675′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.2 kb of the gene's 4 kb; 645 of those bases code for the protein.

    How a genome test reads RPL10

    1

    position in RPL10 where ClinVar classes a change as pathogenic or likely pathogenic

    1 of them (100%) falls in a region short reads find hard.

    • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.

    A whole genome covers all 4 kb of RPL10, introns included, not only the 2.2 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). RPL10 gene: ribosomal protein L10. Retrieved 16 October 2026, from https://dantelabs.com/genes/rpl10

    Vancouver

    Dante Labs. RPL10 gene: ribosomal protein L10 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rpl10

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