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Gene

HS2ST1

heparan sulfate 2-O-sulfotransferase 1

Summary

Cytogenetic location
1p22.3
Coordinates
Chromosome 1: 86,914,635–87,109,982 (GRCh38)
Exons
7 exons across 195.3 kb
Protein
356 amino acids
Also known as
KIAA0448
MANE Select transcript
ENST00000370550.10NM_012262.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads HS2ST1 yet. The test sequences your whole genome, so your data includes it all the same.

How HS2ST1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where HS2ST1 sits. HS2ST1 and 5 genes near it on chromosome 1, from 86,512,309 to 87,512,308.Chromosome 11p22.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4486.6 Mb86.8 Mb87 Mb87.2 Mb87.4 MbCLCA4: 86,547,076–86,580,758, forward strandCLCA4SH3GLB1: 86,704,510–86,748,184, forward strandSH3GLB1SELENOF: 86,861,214–86,914,424, reverse strandSELENOFHS2ST1: 86,914,635–87,109,982, forward strandHS2ST1: 86,993,009–87,169,204, forward strandLMO4: 87,328,428–87,348,923, forward strandLMO4Diagram of HS2ST1: 7 exons on the forward strand of chromosome 1Exon 1: 1 known disease-causing siteExon 1: 86,914,635–86,915,160, 526 basesExon 2: 87,072,934–87,073,172, 239 basesExon 3: 87,084,194–87,084,279, 86 basesExon 4: 87,092,531–87,092,669, 139 basesExon 5: 87,097,838–87,097,935, 98 basesExon 6: 87,103,432–87,103,589, 158 basesExon 7: 87,104,470–87,109,982, 5,513 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.8 kb of the gene's 195.3 kb; 1,071 of those bases code for the protein.

How a genome test reads HS2ST1

1

position in HS2ST1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 195.3 kb of HS2ST1, introns included, not only the 6.8 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). HS2ST1 gene: heparan sulfate 2-O-sulfotransferase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/hs2st1

Vancouver

Dante Labs. HS2ST1 gene: heparan sulfate 2-O-sulfotransferase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hs2st1

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