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Gene

MAP3K7

mitogen-activated protein kinase kinase kinase 7

Summary

Cytogenetic location
6q15
Coordinates
Chromosome 6: 90,513,579–90,587,072 (GRCh38)
Exons
17 exons across 73.5 kb
Protein
606 amino acids
Also known as
MEKK7
Previous symbols
TAK1
MANE Select transcript
ENST00000369329.8NM_145331.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MAP3K7 yet. The test sequences your whole genome, so your data includes it all the same.

How MAP3K7 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where MAP3K7 sits. MAP3K7 and 1 gene near it on chromosome 6, from 90,050,326 to 91,050,325.Chromosome 66q15p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2790.2 Mb90.4 Mb90.6 Mb90.8 Mb91 MbBACH2: 89,926,528–90,296,982, reverse strandBACH2MAP3K7: 90,513,579–90,587,072, reverse strandMAP3K7Diagram of MAP3K7: 17 exons on the reverse strand of chromosome 6Exon 16: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 17: 90,513,579–90,516,681, 3,103 basesExon 16: 90,518,447–90,518,562, 116 basesExon 15: 90,519,258–90,519,319, 62 basesExon 14: 90,523,678–90,523,783, 106 basesExon 13: 90,536,337–90,536,401, 65 basesExon 12: 90,544,552–90,544,632, 81 basesExon 11: 90,547,258–90,547,387, 130 basesExon 10: 90,548,047–90,548,177, 131 basesExon 9: 90,550,468–90,550,549, 82 basesExon 8: 90,552,049–90,552,179, 131 basesExon 7: 90,553,458–90,553,586, 129 basesExon 6: 90,556,500–90,556,624, 125 basesExon 5: 90,560,076–90,560,214, 139 basesExon 4: 90,561,622–90,561,667, 46 basesExon 3: 90,568,558–90,568,623, 66 basesExon 2: 90,571,697–90,571,807, 111 basesExon 1: 90,586,764–90,587,072, 309 bases1716141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 73.5 kb; 1,821 of those bases code for the protein.

How a genome test reads MAP3K7

8

positions in MAP3K7 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 73.5 kb of MAP3K7, introns included, not only the 4.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MAP3K7 gene: mitogen-activated protein kinase kinase kinase 7. Retrieved 16 October 2026, from https://dantelabs.com/genes/map3k7

Vancouver

Dante Labs. MAP3K7 gene: mitogen-activated protein kinase kinase kinase 7 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/map3k7

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