Gene
MDGA2
MAM domain containing glycosylphosphatidylinositol anchor 2
- HGNC 19835↗(opens in a new tab)
- Ensembl gene ENSG00000139915↗(opens in a new tab)
- NCBI Gene 161357↗(opens in a new tab)
Summary
- Cytogenetic location
- 14q21.3
- Coordinates
- Chromosome 14: 46,840,092–47,675,605 (GRCh38)
- Exons
- 17 exons across 835.5 kb
- Protein
- 1,025 amino acids
- Previous symbols
- MAMDC1
- MANE Select transcript
- ENST00000399232.8NM_001113498.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How MDGA2 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 5.7 kb of the gene's 835.5 kb; 3,078 of those bases code for the protein.
Traits linked to MDGA2
The Human Phenotype Ontology lists these as features of the rare conditions MDGA2 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Absent speech development
- Atypical absence seizure
- Brain degeneration
- Brisk reflexes
- Clonic seizure
- Delayed ability to walk
- Delayed CNS myelination
- Delayed speech and language development
Show 51 more traits
- Encephalopathy
- Epilepsy
- Intellectual disability
- Intellectual disability, severe
- Interictal EEG abnormality
- Involuntary movements
- Irritability
- Jerking
- More active than typical
- Motor delay
- Severe global developmental delay
- Small basal ganglia
- Bilateral tonic-clonic seizure with focal onset
- Delayed ability to sit
- Reduced cerebral white matter volume
- Small hippocampus
- Abnormality of coordination
- Bilateral tonic-clonic seizure with generalized onset
- Decreased reflex response
- Degeneration of cerebrum
- Difficulty sleeping
- EEG with multifocal slow activity
- Epileptic spasm
- Global developmental delay
- Hippocampal atrophy
- Loss of developmental milestones
- Multifocal epileptiform discharges
- Myoclonic seizure
- Repeated seizures without recovery between them
- Seizure affecting one half of brain
- Abnormal corpus callosum morphology
- Abnormal diffusion weighted cerebral MRI morphology
- Abnormal gait
- Abnormal myelination
- Ataxia
- Attention deficit
- Autism
- Behavioral abnormality
- Continuous spike and waves during slow sleep
- Diminished deep tendon reflex
- Disorder of involuntary muscle movements
- EEG with abnormally slow frequencies
- EEG with burst suppression
- Hypsarrhythmia
- Impulsivity
- Lateral ventricle dilatation
- Mental deterioration
- Sudden loss of muscle tone
- Tonic seizure
- Tremor
- Unsteady walk
Abnormality of head or neck
- Weakness of facial musculature
- Wide nasal bridge
- Development of small head that was not present at birth
- Highly arched eyebrow
- Tented mouth
- High forehead
- High frontal hairline
- Long lower eyelashes
Show 23 more traits
- Narrow forehead
- Short philtrum
- Thin eyebrow
- Upward slanting of the opening between the eyelids
- Abnormally small head
- Big maxilla
- Bulbous nose
- Decreased volume of lower lip
- Downturned corners of mouth
- Downward slanting of the opening between the eyelids
- Enlarged cisterna magna
- Eye folds
- Failure of development of between one and six teeth
- Frontal bossing
- High palate
- Long eyelashes
- Long face
- Long, narrow head
- Medial flaring of the eyebrow
- Parietal bossing
- Prominent forehead
- Smooth philtrum
- Underdeveloped tissue around nostril
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). MDGA2 gene: MAM domain containing glycosylphosphatidylinositol anchor 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/mdga2
Dante Labs. MDGA2 gene: MAM domain containing glycosylphosphatidylinositol anchor 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/mdga2
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