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Gene

COMT

catechol-O-methyltransferase

Summary

Cytogenetic location
22q11.21
Coordinates
Chromosome 22: 19,941,772–19,969,975 (GRCh38)
Exons
6 exons across 28.2 kb
Protein
271 amino acids
MANE Select transcript
ENST00000361682.11NM_000754.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads COMT yet. The test sequences your whole genome, so your data includes it all the same.

How COMT is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 22, with a bracket where COMT sits. COMT and 23 genes near it on chromosome 22, from 19,455,874 to 20,455,873.Chromosome 2222q11.21p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3319.6 Mb19.8 Mb20 Mb20.2 Mb20.4 MbUFD1: 19,449,899–19,479,695, reverse strandUFD1CDC45: 19,479,457–19,520,612, forward strandCDC45CLDN5: 19,517,452–19,527,545, reverse strandCLDN5SEPTIN5: 19,714,117–19,724,781, forward strandSEPTIN5: 19,717,220–19,724,772, forward strandGP1BB: 19,723,539–19,724,776, forward strandGP1BBTBX1: 19,756,703–19,783,593, forward strandTBX1GNB1L: 19,781,243–19,854,947, reverse strandGNB1LRTL10: 19,846,138–19,854,939, reverse strandRTL10TXNRD2: 19,875,517–19,941,934, reverse strandTXNRD2COMT: 19,941,772–19,969,975, forward strandCOMTARVCF: 19,969,866–20,016,862, reverse strandARVCFTANGO2: 20,016,615–20,067,962, forward strandTANGO2DGCR8: 20,080,025–20,111,877, forward strandDGCR8TRMT2A: 20,111,866–20,117,392, reverse strandTRMT2ARANBP1: 20,115,877–20,128,037, forward strandRANBP1ZDHHC8: 20,129,456–20,148,007, forward strandZDHHC8CCDC188: 20,146,381–20,151,059, reverse strandRTN4R: 20,241,415–20,283,246, reverse strandRTN4RDGCR6L: 20,312,140–20,320,085, reverse strandDGCR6LZNF74: 20,394,115–20,409,406, forward strandZNF74SCARF2: 20,424,584–20,438,332, reverse strandSCARF2: 20,429,241–20,446,620, reverse strandKLHL22: 20,441,519–20,496,893, reverse strandKLHL22Diagram of COMT: 6 exons on the forward strand of chromosome 22Exon 1: 19,941,772–19,941,897, 126 basesExon 2: 19,961,199–19,961,289, 91 basesExon 3: 19,962,527–19,962,815, 289 basesExon 4: 19,963,566–19,963,759, 194 basesExon 5: 19,964,168–19,964,299, 132 basesExon 6: 19,968,536–19,969,975, 1,440 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 28.2 kb; 816 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). COMT gene: catechol-O-methyltransferase. Retrieved 16 October 2026, from https://dantelabs.com/genes/comt

Vancouver

Dante Labs. COMT gene: catechol-O-methyltransferase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/comt

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