Gene
JMJD1C
jumonji domain containing 1C
- HGNC 12313↗(opens in a new tab)
- Ensembl gene ENSG00000171988↗(opens in a new tab)
- NCBI Gene 221037↗(opens in a new tab)
Summary
- Cytogenetic location
- 10q21.3
- Coordinates
- Chromosome 10: 63,167,225–63,465,977 (GRCh38)
- Exons
- 26 exons across 298.8 kb
- Protein
- 2,540 amino acids
- Also known as
- DKFZp761F0118, KIAA1380, FLJ14374, KDM3C
- Previous symbols
- TRIP8
- MANE Select transcript
- ENST00000399262.7NM_032776.3
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Intellectual Disability
One of 233 genes linked to it
- 1 GenCC submitter rates it definitive or strong
How JMJD1C is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 8.8 kb of the gene's 298.8 kb; 7,623 of those bases code for the protein.
Genes linked to the same conditions
- ACSL4acyl-CoA synthetase long chain family member 4Shares 1 condition
- ADKadenosine kinaseShares 1 condition
- ADNPactivity dependent neuroprotector homeoboxShares 1 condition
- AFF2ALF transcription elongation factor 2Shares 1 condition
- AHDC1AT-hook DNA binding motif containing 1Shares 1 condition
- ALKBH8alkB homolog 8, tRNA methyltransferaseShares 1 condition
- ANK3ankyrin 3Shares 1 condition
- ANKRD11ankyrin repeat domain 11Shares 1 condition
- AP1S2adaptor related protein complex 1 subunit sigma 2Shares 1 condition
- AP2M1adaptor related protein complex 2 subunit mu 1Shares 1 condition
- ARHGEF9Cdc42 guanine nucleotide exchange factor 9Shares 1 condition
- ARID1AAT-rich interaction domain 1AShares 1 condition
Traits linked to JMJD1C
The Human Phenotype Ontology lists these as features of the rare conditions JMJD1C can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Abnormal facial shape
- Bulbous nose
- Cleft palate
- Corners of eye widely separated
- Eye folds
- Flattening of the skull base
- Prominent nasal bridge
- Upward slanting of the opening between the eyelids
Show 19 more traits
- Wide nasal bridge
- Abnormal dentition
- Abnormality of the eyelid
- Abnormality of the skull
- Dental cavities
- Long face
- Long philtrum
- Short neck
- Zygomatic flattening
- Abnormal tooth enamel
- Abnormally small head
- Blockage of the rear opening of the nasal cavity
- Downward slanting of the opening between the eyelids
- Little lower jaw
- Multiple suture craniosynostosis
- Narrow mouth
- Retinal arteriolar tortuosity
- Short philtrum
- Tall shaped head
Abnormality of the digestive system
- Anorectal anomaly
- Constipation
- Absent anus
- Acid reflux
- Enlarged colon lacking nerve cells
- Feeding difficulties in infancy
- Gallstones
- Inguinal hernia
Show 3 more traits
Abnormality of the eye
- Drooping upper eyelid
- New blood vessel formation in cornea
- Posterior embryotoxon
- Abnormally small eyeball
- Clouding of the lens of the eye
- Cross-eyed
- Glaucoma
- Optic atrophy
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
- The ACMG secondary findings list, SF v3.2.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). JMJD1C gene: jumonji domain containing 1C. Retrieved 17 October 2026, from https://dantelabs.com/genes/jmjd1c
Dante Labs. JMJD1C gene: jumonji domain containing 1C [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/jmjd1c
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