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Gene

CRNKL1

crooked neck pre-mRNA splicing factor 1

Summary

Cytogenetic location
20p11.23
Coordinates
Chromosome 20: 20,034,368–20,052,466 (GRCh38)
Exons
14 exons across 18.1 kb
Protein
687 amino acids
Also known as
CRN, CLF, SYF3, Clf1
MANE Select transcript
ENST00000536226.2NM_001278628.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CRNKL1 yet. The test sequences your whole genome, so your data includes it all the same.

How CRNKL1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 20, with a bracket where CRNKL1 sits. CRNKL1 and 6 genes near it on chromosome 20, from 19,543,417 to 20,543,416.Chromosome 2020p11.23p13p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12q13.11q13.12q13.13q13.2q13.31q13.32q13.3319.6 Mb19.8 Mb20 Mb20.2 Mb20.4 MbSLC24A3: 19,212,495–19,724,784, forward strandSLC24A3RIN2: 19,757,594–20,003,572, forward strandRIN2NAA20: 20,017,310–20,034,387, forward strandNAA20CRNKL1: 20,034,368–20,052,466, reverse strandCRNKL1CFAP61: 20,052,511–20,360,703, forward strandCFAP61INSM1: 20,368,104–20,370,949, forward strandINSM1RALGAPA2: 20,389,530–20,712,673, reverse strandRALGAPA2Diagram of CRNKL1: 14 exons on the reverse strand of chromosome 20Exon 4: 1 known disease-causing siteExon 14: 20,034,368–20,036,362, 1,995 basesExon 13: 20,037,323–20,037,571, 249 basesExon 12: 20,038,349–20,038,450, 102 basesExon 11: 20,039,609–20,039,848, 240 basesExon 10: 20,040,686–20,040,766, 81 basesExon 9: 20,041,566–20,041,625, 60 basesExon 8: 20,042,325–20,042,516, 192 basesExon 7: 20,043,492–20,043,662, 171 basesExon 6: 20,045,308–20,045,486, 179 basesExon 5: 20,047,765–20,047,931, 167 basesExon 4: 20,048,343–20,048,501, 159 basesExon 3: 20,049,340–20,049,431, 92 basesExon 2: 20,050,470–20,050,622, 153 basesExon 1: 20,052,292–20,052,466, 175 bases14131211109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4 kb of the gene's 18.1 kb; 2,064 of those bases code for the protein.

How a genome test reads CRNKL1

1

position in CRNKL1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.1 kb of CRNKL1, introns included, not only the 4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CRNKL1 gene: crooked neck pre-mRNA splicing factor 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/crnkl1

Vancouver

Dante Labs. CRNKL1 gene: crooked neck pre-mRNA splicing factor 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/crnkl1

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