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Gene

KIT

KIT proto-oncogene, receptor tyrosine kinase

Summary

Cytogenetic location
4q12
Coordinates
Chromosome 4: 54,657,957–54,740,715 (GRCh38)
Exons
21 exons across 82.8 kb
Protein
976 amino acids
Also known as
CD117, SCFR, C-Kit
Previous symbols
PBT
MANE Select transcript
ENST00000288135.6NM_000222.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads KIT yet. The test sequences your whole genome, so your data includes it all the same.

How KIT is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where KIT sits. KIT and 3 genes near it on chromosome 4, from 54,199,336 to 55,199,335.Chromosome 44q12p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.254.2 Mb54.4 Mb54.6 Mb54.8 Mb55 Mb: 53,377,839–54,295,272, forward strandPDGFRA: 54,229,130–54,298,246, forward strandPDGFRAKIT: 54,657,957–54,740,715, forward strandKITKDR: 55,078,144–55,125,623, reverse strandKDRDiagram of KIT: 21 exons on the forward strand of chromosome 4Exon 1: 2 known disease-causing sitesExon 2: 3 known disease-causing sitesExon 3: 7 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 8: 4 known disease-causing sitesExon 9: 3 known disease-causing sitesExon 10: 1 known disease-causing siteExon 11: 16 known disease-causing sitesExon 12: 4 known disease-causing sitesExon 13: 4 known disease-causing sitesExon 14: 3 known disease-causing sitesExon 15: 2 known disease-causing sitesExon 16: 3 known disease-causing sitesExon 17: 6 known disease-causing sitesExon 18: 3 known disease-causing sitesExon 19: 2 known disease-causing sitesExon 20: 2 known disease-causing sitesExon 1: 54,657,957–54,658,081, 125 basesExon 2: 54,695,512–54,695,781, 270 basesExon 3: 54,698,284–54,698,565, 282 basesExon 4: 54,699,630–54,699,766, 137 basesExon 5: 54,703,724–54,703,892, 169 basesExon 6: 54,707,098–54,707,287, 190 basesExon 7: 54,709,424–54,709,539, 116 basesExon 8: 54,723,584–54,723,698, 115 basesExon 9: 54,725,857–54,726,050, 194 basesExon 10: 54,727,218–54,727,324, 107 basesExon 11: 54,727,416–54,727,542, 127 basesExon 12: 54,727,823–54,727,927, 105 basesExon 13: 54,728,011–54,728,121, 111 basesExon 14: 54,729,335–54,729,485, 151 basesExon 15: 54,731,328–54,731,419, 92 basesExon 16: 54,731,871–54,731,998, 128 basesExon 17: 54,733,070–54,733,192, 123 basesExon 18: 54,736,498–54,736,609, 112 basesExon 19: 54,736,721–54,736,820, 100 basesExon 20: 54,737,175–54,737,280, 106 basesExon 21: 54,738,429–54,740,715, 2,287 bases15101520215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.1 kb of the gene's 82.8 kb; 2,931 of those bases code for the protein.

How a genome test reads KIT

91

positions in KIT where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 82.8 kb of KIT, introns included, not only the 5.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). KIT gene: KIT proto-oncogene, receptor tyrosine kinase. Retrieved 16 October 2026, from https://dantelabs.com/genes/kit

Vancouver

Dante Labs. KIT gene: KIT proto-oncogene, receptor tyrosine kinase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/kit

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