Skip to content
Use your HSA or FSA funds

Gene

ADAMTS3

ADAM metallopeptidase with thrombospondin type 1 motif 3

Summary

Cytogenetic location
4q13.3
Coordinates
Chromosome 4: 72,280,969–72,569,221 (GRCh38)
Exons
22 exons across 288.3 kb
Protein
1,205 amino acids
Inheritance
Autosomal recessive
Also known as
KIAA0366, ADAMTS-4
MANE Select transcript
ENST00000286657.10NM_014243.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Primary Lymphoedema & Lymphatic Malformations

    • Hennekam Syndrome Type 3Autosomal recessive

      A condition caused by changes in ADAMTS3 that combines lymphoedema and swollen lymph vessels in the gut and other organs.

      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ADAMTS3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 4, with a bracket where ADAMTS3 sits. ADAMTS3 and 1 gene near it on chromosome 4, from 71,925,095 to 72,925,094.Chromosome 44q13.3p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.272 Mb72.2 Mb72.4 Mb72.6 Mb72.8 MbNPFFR2: 72,031,902–72,148,962, forward strandNPFFR2ADAMTS3: 72,280,969–72,569,221, reverse strandADAMTS3Diagram of ADAMTS3: 22 exons on the reverse strand of chromosome 4Exon 22: 72,280,969–72,283,704, 2,736 basesExon 21: 72,288,751–72,288,868, 118 basesExon 20: 72,290,855–72,291,062, 208 basesExon 19: 72,295,654–72,295,786, 133 basesExon 18: 72,298,277–72,298,442, 166 basesExon 17: 72,303,917–72,304,080, 164 basesExon 16: 72,305,987–72,306,067, 81 basesExon 15: 72,309,397–72,309,520, 124 basesExon 14: 72,311,048–72,311,181, 134 basesExon 13: 72,312,291–72,312,466, 176 basesExon 12: 72,313,677–72,313,822, 146 basesExon 11: 72,315,858–72,315,971, 114 basesExon 10: 72,318,572–72,318,704, 133 basesExon 9: 72,319,332–72,319,475, 144 basesExon 8: 72,319,858–72,319,963, 106 basesExon 7: 72,320,714–72,320,870, 157 basesExon 6: 72,323,014–72,323,097, 84 basesExon 5: 72,339,494–72,339,693, 200 basesExon 4: 72,414,815–72,414,971, 157 basesExon 3: 72,548,478–72,548,884, 407 basesExon 2: 72,567,374–72,567,401, 28 basesExon 1: 72,568,694–72,569,221, 528 bases22201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.2 kb of the gene's 288.3 kb; 3,618 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ADAMTS3 gene: ADAM metallopeptidase with thrombospondin type 1 motif 3. Retrieved 16 October 2026, from https://dantelabs.com/genes/adamts3

Vancouver

Dante Labs. ADAMTS3 gene: ADAM metallopeptidase with thrombospondin type 1 motif 3 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/adamts3

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test