Gene
GTF3C3
general transcription factor IIIC subunit 3
- HGNC 4666↗(opens in a new tab)
- Ensembl gene ENSG00000119041↗(opens in a new tab)
- NCBI Gene 9330↗(opens in a new tab)
Summary
- Cytogenetic location
- 2q33.1
- Coordinates
- Chromosome 2: 196,763,035–196,799,683 (GRCh38)
- Exons
- 18 exons across 36.6 kb
- Protein
- 886 amino acids
- Also known as
- TFiiiC2-102, TFIIIC102
- MANE Select transcript
- ENST00000263956.8NM_012086.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome TestCurated reports relevant to this gene
No Genome Test report reads GTF3C3 yet. The test sequences your whole genome, so your data includes it all the same.
How GTF3C3 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.3 kb of the gene's 36.6 kb; 2,661 of those bases code for the protein.
How a genome test reads GTF3C3
1
position in GTF3C3 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 36.6 kb of GTF3C3, introns included, not only the 4.3 kb of exons.
Traits linked to GTF3C3
The Human Phenotype Ontology lists these as features of the rare conditions GTF3C3 can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Crease in skin under the eye
- Dandy-Walker malformation
- Development of small head that was not present at birth
- Enlarged cisterna magna
- Full lower lip
- Long eyelashes
- Long face
- Monobrow
Show 32 more traits
- Round face
- Short nose
- Tented mouth
- Abnormally small head
- Full cheeks
- High forehead
- Narrow forehead
- Small head present at birth
- Almond shaped eyes
- Broad chin
- Broad eyebrow
- Broad nasal tip
- Broad opening between the eyelids
- Bulbous nose
- Cleft palate
- Deep bite
- Downward slanting of the opening between the eyelids
- Drooling
- Eye folds
- Facial asymmetry
- Full lips
- Gap between teeth
- High, narrow palate
- Increased size of tooth
- Little lower jaw
- Long philtrum
- Low frontal hairline
- Pierre-Robin sequence
- Smooth philtrum
- Thick eyebrow
- Upward slanting of the opening between the eyelids
- Wide nasal bridge
Abnormality of the nervous system
- Ataxia
- Bilateral tonic-clonic seizure with generalized onset
- Brief seizures with staring spells
- Cerebral palsy
- Choreoathetosis
- Clonic seizure
- Clonus
- Degeneration of cerebellum
Show 28 more traits
- Dystonia
- Fluid-filled sac located in membrane surrounding brain or spinal cord
- Focal impaired awareness seizure
- Generalized brain degeneration
- Generalized tonic seizure
- Global developmental delay
- Hypoplasia of the pons
- Inability to coordinate movements when walking
- Intellectual disability
- Jerking
- Lateral ventricle dilatation
- Myoclonic seizure
- Simple febrile seizure
- Simplified gyral pattern
- Small cerebellum
- Tetraparesis
- Thin corpus callosum
- Tonic seizure
- Tremor
- Underdevelopment of part of brain called corpus callosum
- EEG abnormality
- Intellectual disability, severe
- IQ between 34 and 49
- Unsteady walk
- Attention deficit
- Autism spectrum disorder
- Epilepsy
- Intellectual disability, mild
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). GTF3C3 gene: general transcription factor IIIC subunit 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/gtf3c3
Dante Labs. GTF3C3 gene: general transcription factor IIIC subunit 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gtf3c3
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