Skip to content
Use your HSA or FSA funds

Gene

TMEM53

transmembrane protein 53

Summary

Cytogenetic location
1p34.1
Coordinates
Chromosome 1: 44,653,247–44,674,481 (GRCh38)
Exons
3 exons across 21.2 kb
Protein
277 amino acids
Also known as
FLJ22353, NET4
MANE Select transcript
ENST00000372237.8NM_024587.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads TMEM53 yet. The test sequences your whole genome, so your data includes it all the same.

How TMEM53 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 1, with a bracket where TMEM53 sits. TMEM53 and 15 genes near it on chromosome 1, from 44,163,864 to 45,163,863.Chromosome 11p34.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4444.2 Mb44.4 Mb44.6 Mb44.8 Mb45 MbDMAP1: 44,213,427–44,230,038, forward strandDMAP1ERI3: 44,221,070–44,355,267, reverse strandERI3RNF220: 44,405,142–44,651,724, forward strandRNF220TMEM53: 44,653,247–44,674,481, reverse strandTMEM53ARMH1: 44,674,692–44,725,591, forward strandARMH1KIF2C: 44,739,810–44,767,767, forward strandKIF2CRPS8: 44,775,251–44,779,124, forward strandRPS8BEST4: 44,781,836–44,791,550, reverse strandBEST4PLK3: 44,799,915–44,805,995, forward strandPLK3DYNLT4: 44,805,885–44,807,417, reverse strandDYNLT4BTBD19: 44,808,506–44,817,381, forward strandPTCH2: 44,819,154–44,843,253, reverse strandEIF2B3: 44,850,464–44,986,722, reverse strandEIF2B3HECTD3: 45,002,540–45,011,369, reverse strandHECTD3UROD: 45,010,950–45,015,577, forward strandURODZSWIM5: 45,016,395–45,306,209, reverse strandZSWIM5Diagram of TMEM53: 3 exons on the reverse strand of chromosome 1Exon 3: 44,653,247–44,655,209, 1,963 basesExon 2: 44,660,174–44,660,295, 122 basesExon 1: 44,674,331–44,674,481, 151 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.2 kb of the gene's 21.2 kb; 834 of those bases code for the protein.

How a genome test reads TMEM53

1

position in TMEM53 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 21.2 kb of TMEM53, introns included, not only the 2.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TMEM53 gene: transmembrane protein 53. Retrieved 16 October 2026, from https://dantelabs.com/genes/tmem53

Vancouver

Dante Labs. TMEM53 gene: transmembrane protein 53 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tmem53

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test