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Gene

RPS19

ribosomal protein S19

Summary

Cytogenetic location
19q13.2
Coordinates
Chromosome 19: 41,860,255–41,872,925 (GRCh38)
Exons
6 exons across 12.7 kb
Protein
145 amino acids
Inheritance
Autosomal dominant
Also known as
S19, eS19, DBA
Previous symbols
LOH19CR1
MANE Select transcript
ENST00000598742.6NM_001022.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Diamond-Blackfan Anemia

    • Autosomal dominant

      A congenital aregenerative and often macrocytic anemia with erythroblastopenia.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How RPS19 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where RPS19 sits. RPS19 and 36 genes near it on chromosome 19, from 41,366,590 to 42,366,589.Chromosome 1919q13.2p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4341.4 Mb41.6 Mb41.8 Mb42 Mb42.2 Mb: 41,350,853–41,425,001, forward strandTMEM91: 41,350,885–41,384,742, forward strandEXOSC5: 41,367,173–41,397,441, reverse strandBCKDHA: 41,397,792–41,425,092, forward strandBCKDHAB3GNT8: 41,422,878–41,428,730, reverse strandB3GNT8DMAC2: 41,431,317–41,440,717, reverse strandDMAC2ERICH4: 41,443,152–41,444,765, forward strandERICH4CEACAM21: 41,549,518–41,586,844, forward strandCEACAM21CEACAM4: 41,619,014–41,627,082, reverse strandCEACAM4CEACAM7: 41,666,629–41,706,976, reverse strandCEACAM7CEACAM5: 41,708,585–41,730,519, forward strandCEACAM5: 41,708,657–41,756,737, forward strandCEACAM6: 41,750,977–41,772,211, forward strandCEACAM6CEACAM3: 41,796,587–41,811,557, forward strandCEACAM3LYPD4: 41,837,073–41,844,718, reverse strandLYPD4DMRTC2: 41,844,743–41,852,333, forward strandDMRTC2RPS19: 41,860,255–41,872,925, forward strandRPS19CD79A: 41,877,104–41,881,372, forward strandCD79AARHGEF1: 41,883,063–41,930,150, forward strandARHGEF1ERFL: 41,907,704–41,928,449, reverse strandERFLRABAC1: 41,956,681–41,959,390, reverse strandRABAC1: 41,956,879–41,994,232, reverse strandATP1A3: 41,966,582–41,997,497, reverse strandATP1A3GRIK5: 41,998,315–42,070,240, reverse strandGRIK5ZNF574: 42,068,477–42,083,096, forward strandZNF574POU2F2: 42,086,110–42,196,585, reverse strandPOU2F2DEDD2: 42,198,593–42,220,140, reverse strandDEDD2: 42,215,133–42,232,149, reverse strandZNF526: 42,216,774–42,231,887, forward strandZNF526GSK3A: 42,226,225–42,242,625, reverse strandGSK3A: 42,234,583–42,255,132, reverse strandERF: 42,247,569–42,255,172, reverse strandCIC: 42,268,508–42,295,801, forward strandCICPAFAH1B3: 42,297,023–42,303,546, reverse strandPAFAH1B3PRR19: 42,302,098–42,310,821, forward strandPRR19TMEM145: 42,313,299–42,325,064, forward strandTMEM145MEGF8: 42,325,518–42,378,769, forward strandMEGF8Diagram of RPS19: 6 exons on the forward strand of chromosome 19Exon 2: 14 known disease-causing sitesExon 3: 11 known disease-causing sitesExon 4: 17 known disease-causing sitesExon 5: 8 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 1: 41,860,255–41,860,289, 35 basesExon 2: 41,860,775–41,860,845, 71 basesExon 3: 41,861,112–41,861,212, 101 basesExon 4: 41,869,031–41,869,214, 184 basesExon 5: 41,869,699–41,869,753, 55 basesExon 6: 41,871,351–41,872,925, 1,575 bases1234565′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2 kb of the gene's 12.7 kb; 438 of those bases code for the protein.

How a genome test reads RPS19

62

positions in RPS19 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 12.7 kb of RPS19, introns included, not only the 2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). RPS19 gene: ribosomal protein S19. Retrieved 16 October 2026, from https://dantelabs.com/genes/rps19

Vancouver

Dante Labs. RPS19 gene: ribosomal protein S19 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/rps19

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