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Gene

MAF

MAF bZIP transcription factor

Summary

Cytogenetic location
16q23.2
Coordinates
Chromosome 16: 79,593,838–79,600,737 (GRCh38)
Exons
2 exons across 6.9 kb
Protein
403 amino acids
Also known as
c-MAF
MANE Select transcript
ENST00000326043.5NM_005360.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated report relevant to this gene

  • Hereditary Congenital & Juvenile Cataract

    • Early-Onset Non-Syndromic Cataract

      Cataract that appears at birth or early in life without other features, caused by changes in lens genes such as the crystallins (CRYAA, CRYBB2, CRYGD and others), GJA3, GJA8 and MIP.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Early detection and surgery in children help prevent permanent vision loss from amblyopia, and family members can be offered eye checks.

How MAF is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 16, with a bracket where MAF sits. MAF and 1 gene near it on chromosome 16, from 79,097,288 to 80,097,287.Chromosome 1616q23.2p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.379.2 Mb79.4 Mb79.6 Mb79.8 Mb80 MbWWOX: 78,099,400–79,212,667, forward strandWWOXMAF: 79,593,838–79,600,737, reverse strandMAFDiagram of MAF: 2 exons on the reverse strand of chromosome 16Exon 1: 16 known disease-causing sitesExon 2: 79,593,838–79,594,553, 716 basesExon 1: 79,598,785–79,600,737, 1,953 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.7 kb of the gene's 6.9 kb; 1,212 of those bases code for the protein.

How a genome test reads MAF

16

positions in MAF where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 6.9 kb of MAF, introns included, not only the 2.7 kb of exons.

Genes linked to the same conditions

Traits linked to MAF

The Human Phenotype Ontology lists these as features of the rare conditions MAF can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MAF gene: MAF bZIP transcription factor. Retrieved 17 October 2026, from https://dantelabs.com/genes/maf

Vancouver

Dante Labs. MAF gene: MAF bZIP transcription factor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/maf

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