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Gene

PIGL

phosphatidylinositol glycan anchor biosynthesis class L

Summary

Cytogenetic location
17p11.2
Coordinates
Chromosome 17: 16,217,210–16,326,411 (GRCh38)
Exons
7 exons across 109.2 kb
Protein
252 amino acids
Also known as
PIG-L
MANE Select transcript
ENST00000225609.10NM_004278.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • GPI Anchor Biosynthesis Defects

    • Disorders of GPI Anchor Biosynthesis

      A group of inherited conditions caused by variants in the PIG, PGAP and related genes needed to make and attach the GPI anchor, typically causing developmental delay, low muscle tone and epilepsy.

      • 4 GenCC submitters rate it definitive or strong

Broader groupings

  • Congenital Disorders of Glycosylation

    • Congenital Disorders of Glycosylation (CDG)

      One of 98 genes linked to it

      A large group of inherited conditions in which sugar chains (glycans) are not correctly built or attached to proteins and lipids, often affecting the brain, liver, blood clotting, growth and many other body systems. Most are autosomal recessive, but some are X-linked or autosomal dominant.

      • 4 GenCC submitters rate it definitive or strong

  • Intellectual Disability

    • One of 233 genes linked to it

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong

How PIGL is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where PIGL sits. PIGL and 12 genes near it on chromosome 17, from 15,771,811 to 16,771,810.Chromosome 1717p11.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.315.8 Mb16 Mb16.2 Mb16.4 Mb16.6 MbADORA2B: 15,945,093–15,976,467, forward strandADORA2BZSWIM7: 15,976,219–15,999,717, reverse strandZSWIM7TTC19: 15,999,386–16,068,416, forward strandTTC19NCOR1: 16,029,065–16,218,185, reverse strandNCOR1PIGL: 16,217,210–16,326,411, forward strandPIGLCENPV: 16,340,011–16,353,661, reverse strandCENPVUBB: 16,378,898–16,382,745, forward strandUBBTRPV2: 16,407,465–16,437,861, forward strandTRPV2LRRC75A: 16,441,493–16,492,237, reverse strandLRRC75AZNF287: 16,546,954–16,569,218, reverse strandZNF287ZNF624: 16,620,734–16,653,860, reverse strandZNF624CCDC144A: 16,689,537–16,777,974, forward strandCCDC144A: 16,690,261–16,804,453, forward strandDiagram of PIGL: 7 exons on the forward strand of chromosome 17Exon 1: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 1: 16,217,210–16,217,461, 252 basesExon 2: 16,233,971–16,234,070, 100 basesExon 3: 16,299,888–16,299,978, 91 basesExon 4: 16,313,547–16,313,614, 68 basesExon 5: 16,316,681–16,316,712, 32 basesExon 6: 16,317,775–16,317,908, 134 basesExon 7: 16,325,800–16,326,411, 612 bases124675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.3 kb of the gene's 109.2 kb; 759 of those bases code for the protein.

How a genome test reads PIGL

8

positions in PIGL where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 109.2 kb of PIGL, introns included, not only the 1.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PIGL gene: phosphatidylinositol glycan anchor biosynthesis class L. Retrieved 17 October 2026, from https://dantelabs.com/genes/pigl

Vancouver

Dante Labs. PIGL gene: phosphatidylinositol glycan anchor biosynthesis class L [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/pigl

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