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Gene

PIGB

phosphatidylinositol glycan anchor biosynthesis class B

Summary

Cytogenetic location
15q21.3
Coordinates
Chromosome 15: 55,319,222–55,355,648 (GRCh38)
Exons
12 exons across 36.4 kb
Protein
554 amino acids
Also known as
PIG-B, GPI-MT-III
MANE Select transcript
ENST00000164305.10NM_004855.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • GPI Anchor Biosynthesis Defects

    • Disorders of GPI Anchor Biosynthesis

      A group of inherited conditions caused by variants in the PIG, PGAP and related genes needed to make and attach the GPI anchor, typically causing developmental delay, low muscle tone and epilepsy.

      • ClinGen rates the link moderate
      • 3 GenCC submitters rate it definitive or strong

Broader groupings

  • Epilepsy (Full Panel)

    • Epilepsy

      One of 171 genes linked to it

      A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

      • ClinGen rates the link moderate
      • 3 GenCC submitters rate it definitive or strong

How PIGB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where PIGB sits. PIGB and 9 genes near it on chromosome 15, from 54,837,435 to 55,837,434.Chromosome 1515q21.3p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.355 Mb55.2 Mb55.4 Mb55.6 Mb55.8 MbRSL24D1: 55,180,797–55,197,076, reverse strandRSL24D1RAB27A: 55,202,966–55,319,174, reverse strandRAB27APIGBOS1: 55,317,086–55,319,419, reverse strandPIGBOS1PIGB: 55,319,222–55,355,648, forward strandPIGBCCPG1: 55,319,687–55,408,510, reverse strandCCPG1PIERCE2: 55,408,480–55,418,798, forward strandPIERCE2DNAAF4: 55,410,525–55,508,234, reverse strandDNAAF4PYGO1: 55,538,884–55,588,994, reverse strandPYGO1PRTG: 55,611,544–55,743,203, reverse strandPRTGNEDD4: 55,826,917–55,993,660, reverse strandNEDD4Diagram of PIGB: 12 exons on the forward strand of chromosome 15Exon 1: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 1: 55,319,222–55,319,413, 192 basesExon 2: 55,320,275–55,320,410, 136 basesExon 3: 55,321,273–55,321,390, 118 basesExon 4: 55,327,531–55,327,635, 105 basesExon 5: 55,329,724–55,329,854, 131 basesExon 6: 55,333,867–55,334,007, 141 basesExon 7: 55,339,267–55,339,318, 52 basesExon 8: 55,340,612–55,340,823, 212 basesExon 9: 55,341,738–55,341,802, 65 basesExon 10: 55,350,699–55,350,912, 214 basesExon 11: 55,354,798–55,354,978, 181 basesExon 12: 55,355,286–55,355,648, 363 bases1246810125′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 36.4 kb; 1,665 of those bases code for the protein.

How a genome test reads PIGB

8

positions in PIGB where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 36.4 kb of PIGB, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). PIGB gene: phosphatidylinositol glycan anchor biosynthesis class B. Retrieved 17 October 2026, from https://dantelabs.com/genes/pigb

Vancouver

Dante Labs. PIGB gene: phosphatidylinositol glycan anchor biosynthesis class B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/pigb

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