Skip to content
Use your HSA or FSA funds
Sequence your genome (opens in a new tab)

Gene

NEXMIF

neurite extension and migration factor

Summary

Cytogenetic location
Xq13.3
Coordinates
Chromosome X: 74,732,856–74,925,452 (GRCh38)
Exons
4 exons across 192.6 kb
Protein
1,516 amino acids
Also known as
XPN, MRX98, KIDLIA
Previous symbols
KIAA2022
MANE Select transcript
ENST00000055682.12NM_001008537.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

  • Epilepsy (Full Panel)

    • X-Linked Complex Neurodevelopmental Disorder

      A complex neurodevelopmental disorder that is transmitted via X-linked inheritance, and is characterized by intellectual disability, autism and epilepsy.

      • ClinGen rates the link definitive
      • 1 GenCC submitter rates it definitive or strong

Broader groupings

How NEXMIF is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome X, with a bracket where NEXMIF sits. NEXMIF and 5 genes near it on chromosome X, from 74,329,154 to 75,329,153.Chromosome XXq13.3p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q2874.4 Mb74.6 Mb74.8 Mb75 Mb75.2 MbSLC16A2: 74,421,383–74,534,693, forward strandSLC16A2RLIM: 74,582,976–74,614,646, reverse strandRLIMNEXMIF: 74,732,856–74,925,452, reverse strandNEXMIFABCB7: 75,044,938–75,156,732, reverse strandABCB7UPRT: 75,156,388–75,307,811, forward strandUPRTZDHHC15: 75,327,087–75,523,502, reverse strandZDHHC15Diagram of NEXMIF: 4 exons on the reverse strand of chromosome XExon 3: 66 known disease-causing sitesExon 2: 1 known disease-causing siteExon 4: 74,732,856–74,739,498, 6,643 basesExon 3: 74,740,100–74,744,477, 4,378 basesExon 2: 74,745,572–74,745,697, 126 basesExon 1: 74,924,883–74,925,452, 570 bases43215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 11.7 kb of the gene's 192.6 kb; 4,551 of those bases code for the protein.

How a genome test reads NEXMIF

68

positions in NEXMIF where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 192.6 kb of NEXMIF, introns included, not only the 11.7 kb of exons.

Genes linked to the same conditions

Traits linked to NEXMIF

The Human Phenotype Ontology lists these as features of the rare conditions NEXMIF can cause. Each trait's page lists the other genes linked to it.

Abnormality of the nervous system

Show 44 more traits

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NEXMIF gene: neurite extension and migration factor. Retrieved 17 October 2026, from https://dantelabs.com/genes/nexmif

Vancouver

Dante Labs. NEXMIF gene: neurite extension and migration factor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/nexmif

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test