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Gene

MED12

mediator complex subunit 12

Summary

Cytogenetic location
Xq13.1
Coordinates
Chromosome X: 71,118,596–71,142,450 (GRCh38)
Exons
45 exons across 23.9 kb
Protein
2,177 amino acids
Also known as
CAGH45, HOPA, OPA1, TRAP230, KIAA0192, OKS, ARC240, Kto
Previous symbols
TNRC11, FGS1
MANE Select transcript
ENST00000374080.8NM_005120.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Intellectual Disability

      • One of 233 genes linked to it

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong

    How MED12 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome X, with a bracket where MED12 sits. MED12 and 16 genes near it on chromosome X, from 70,630,523 to 71,630,522.Chromosome XXq13.1p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q2870.8 Mb71 Mb71.2 Mb71.4 Mb71.6 MbTEX11: 70,528,940–70,908,711, reverse strandTEX11SLC7A3: 70,925,556–70,931,149, reverse strandSLC7A3SNX12: 70,963,111–71,073,426, reverse strandSNX12FOXO4: 71,095,839–71,103,535, forward strandCXorf65: 71,103,889–71,106,788, reverse strandCXorf65: 71,103,987–71,111,575, reverse strandIL2RG: 71,107,404–71,112,108, reverse strandIL2RGMED12: 71,118,596–71,142,450, forward strandMED12NLGN3: 71,143,286–71,175,306, forward strandNLGN3GJB1: 71,212,811–71,225,519, forward strandGJB1ZMYM3: 71,239,617–71,255,269, reverse strandZMYM3NONO: 71,254,270–71,301,522, forward strandNONOITGB1BP2: 71,301,717–71,305,371, forward strandITGB1BP2TAF1: 71,366,129–71,532,374, forward strandTAF1OGT: 71,533,068–71,575,892, forward strandOGTGCNA: 71,578,436–71,613,590, forward strandGCNACXCR3: 71,615,912–71,618,545, reverse strandCXCR3Diagram of MED12: 45 exons on the forward strand of chromosome XExon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 7: 2 known disease-causing sitesExon 11: 2 known disease-causing sitesExon 12: 1 known disease-causing siteExon 13: 4 known disease-causing sitesExon 15: 1 known disease-causing siteExon 19: 2 known disease-causing sitesExon 21: 2 known disease-causing sitesExon 22: 2 known disease-causing sitesExon 24: 2 known disease-causing sitesExon 25: 2 known disease-causing sitesExon 26: 1 known disease-causing siteExon 28: 2 known disease-causing sitesExon 29: 2 known disease-causing sitesExon 30: 1 known disease-causing siteExon 32: 2 known disease-causing sitesExon 35: 2 known disease-causing sitesExon 36: 1 known disease-causing siteExon 39: 1 known disease-causing siteExon 41: 2 known disease-causing sitesExon 42: 3 known disease-causing sitesExon 43: 2 known disease-causing sitesExon 44: 1 known disease-causing siteExon 1: 71,118,596–71,118,853, 258 basesExon 2: 71,119,373–71,119,477, 105 basesExon 3: 71,119,686–71,119,877, 192 basesExon 4: 71,120,014–71,120,170, 157 basesExon 5: 71,120,971–71,121,152, 182 basesExon 6: 71,121,327–71,121,437, 111 basesExon 7: 71,121,562–71,121,816, 255 basesExon 8: 71,122,200–71,122,346, 147 basesExon 9: 71,122,508–71,122,607, 100 basesExon 10: 71,122,738–71,122,874, 137 basesExon 11: 71,123,095–71,123,226, 132 basesExon 12: 71,123,594–71,123,720, 127 basesExon 13: 71,124,159–71,124,388, 230 basesExon 14: 71,124,764–71,124,844, 81 basesExon 15: 71,124,976–71,125,146, 171 basesExon 16: 71,125,351–71,125,495, 145 basesExon 17: 71,125,663–71,125,713, 51 basesExon 18: 71,126,036–71,126,154, 119 basesExon 19: 71,126,341–71,126,484, 144 basesExon 20: 71,126,969–71,127,132, 164 basesExon 21: 71,127,336–71,127,467, 132 basesExon 22: 71,127,893–71,128,120, 228 basesExon 23: 71,128,296–71,128,440, 145 basesExon 24: 71,128,598–71,128,718, 121 basesExon 25: 71,129,114–71,129,215, 102 basesExon 26: 71,129,316–71,129,429, 114 basesExon 27: 71,129,680–71,129,855, 176 basesExon 28: 71,130,035–71,130,214, 180 basesExon 29: 71,131,550–71,131,621, 72 basesExon 30: 71,132,073–71,132,206, 134 basesExon 31: 71,132,377–71,132,538, 162 basesExon 32: 71,132,845–71,132,956, 112 basesExon 33: 71,133,123–71,133,212, 90 basesExon 34: 71,134,357–71,134,466, 110 basesExon 35: 71,134,713–71,134,848, 136 basesExon 36: 71,135,092–71,135,253, 162 basesExon 37: 71,136,281–71,136,655, 375 basesExon 38: 71,136,879–71,137,029, 151 basesExon 39: 71,137,187–71,137,383, 197 basesExon 40: 71,137,558–71,137,635, 78 basesExon 41: 71,137,726–71,137,943, 218 basesExon 42: 71,140,635–71,140,857, 223 basesExon 43: 71,141,230–71,141,370, 141 basesExon 44: 71,141,883–71,141,964, 82 basesExon 45: 71,142,175–71,142,450, 276 bases1510152025303540455′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 6.9 kb of the gene's 23.9 kb; 6,534 of those bases code for the protein.

    How a genome test reads MED12

    51

    positions in MED12 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 23.9 kb of MED12, introns included, not only the 6.9 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). MED12 gene: mediator complex subunit 12. Retrieved 16 October 2026, from https://dantelabs.com/genes/med12

    Vancouver

    Dante Labs. MED12 gene: mediator complex subunit 12 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/med12

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