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Gene

MED13

mediator complex subunit 13

Summary

Cytogenetic location
17q23.2
Coordinates
Chromosome 17: 61,942,605–62,065,278 (GRCh38)
Exons
30 exons across 122.7 kb
Protein
2,174 amino acids
Also known as
KIAA0593, TRAP240
Previous symbols
THRAP1
MANE Select transcript
ENST00000397786.7NM_005121.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    How MED13 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 17, with a bracket where MED13 sits. MED13 and 6 genes near it on chromosome 17, from 61,503,942 to 62,503,941.Chromosome 1717q23.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.361.6 Mb61.8 Mb62 Mb62.2 Mb62.4 MbNACA2: 61,590,421–61,591,219, reverse strandNACA2BRIP1: 61,679,139–61,863,561, reverse strandBRIP1INTS2: 61,865,367–61,928,016, reverse strandINTS2MED13: 61,942,605–62,065,278, reverse strandMED13EFCAB3: 62,343,941–62,416,480, forward strandEFCAB3METTL2A: 62,423,866–62,453,385, forward strandMETTL2ATLK2: 62,458,658–62,615,481, forward strandTLK2Diagram of MED13: 30 exons on the reverse strand of chromosome 17Exon 26: 1 known disease-causing siteExon 25: 2 known disease-causing sitesExon 23: 2 known disease-causing sitesExon 21: 1 known disease-causing siteExon 20: 2 known disease-causing sitesExon 19: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 17: 2 known disease-causing sitesExon 16: 3 known disease-causing sitesExon 14: 6 known disease-causing sitesExon 11: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 9: 5 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 6: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 30: 61,942,605–61,946,600, 3,996 basesExon 29: 61,946,917–61,947,017, 101 basesExon 28: 61,950,825–61,950,998, 174 basesExon 27: 61,952,965–61,953,113, 149 basesExon 26: 61,955,382–61,955,567, 186 basesExon 25: 61,955,680–61,955,838, 159 basesExon 24: 61,956,339–61,956,481, 143 basesExon 23: 61,960,867–61,961,090, 224 basesExon 22: 61,961,588–61,961,779, 192 basesExon 21: 61,962,752–61,962,971, 220 basesExon 20: 61,965,006–61,965,468, 463 basesExon 19: 61,966,462–61,966,651, 190 basesExon 18: 61,968,035–61,968,258, 224 basesExon 17: 61,972,727–61,972,888, 162 basesExon 16: 61,982,198–61,983,114, 917 basesExon 15: 61,984,171–61,984,367, 197 basesExon 14: 61,984,651–61,984,865, 215 basesExon 13: 61,985,000–61,985,090, 91 basesExon 12: 61,987,007–61,987,128, 122 basesExon 11: 61,992,540–61,992,621, 82 basesExon 10: 61,995,152–61,995,365, 214 basesExon 9: 62,010,550–62,011,233, 684 basesExon 8: 62,029,541–62,029,651, 111 basesExon 7: 62,029,851–62,030,013, 163 basesExon 6: 62,031,444–62,031,638, 195 basesExon 5: 62,033,787–62,033,984, 198 basesExon 4: 62,035,463–62,035,608, 146 basesExon 3: 62,052,537–62,052,705, 169 basesExon 2: 62,063,067–62,063,301, 235 basesExon 1: 62,065,140–62,065,278, 139 bases3025201510515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 10.5 kb of the gene's 122.7 kb; 6,525 of those bases code for the protein.

    How a genome test reads MED13

    36

    positions in MED13 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 122.7 kb of MED13, introns included, not only the 10.5 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). MED13 gene: mediator complex subunit 13. Retrieved 17 October 2026, from https://dantelabs.com/genes/med13

    Vancouver

    Dante Labs. MED13 gene: mediator complex subunit 13 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/med13

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