Gene
FZD2
frizzled class receptor 2
- HGNC 4040(opens in a new tab)
- Ensembl gene ENSG00000180340(opens in a new tab)
- NCBI Gene 2535(opens in a new tab)
Summary
- Cytogenetic location
- 17q21.31
- Coordinates
- Chromosome 17: 44,557,484–44,561,262 (GRCh38)
- Exons
- 1 exon across 3.8 kb
- Protein
- 565 amino acids
- MANE Select transcript
- ENST00000315323.5NM_001466.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads FZD2 yet. The test sequences your whole genome, so your data includes it all the same.
How FZD2 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.8 kb of the gene's 3.8 kb; 1,698 of those bases code for the protein.
How a genome test reads FZD2
3
positions in FZD2 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 3.8 kb of FZD2, introns included, not only the 3.8 kb of exons.
Traits linked to FZD2
The Human Phenotype Ontology lists these as features of the rare conditions FZD2 can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Depressed nasal bridge
- Midface retrusion
- Nasal tip, upturned
- Short nose
- Wide nasal bridge
- Wide nose
- Abnormality of the gums
- Big calvaria
Show 29 more traits
- Both sided cleft lip
- Broad opening between the eyelids
- Central cleft palate
- Cleft palate
- Cleft tongue
- Curly eyelashes
- Downturned corners of mouth
- Euryblepharon
- Eye folds
- Frontal bossing
- Gum enlargement
- High, narrow palate
- Little lower jaw
- Long eyelashes
- Long philtrum
- Open bite
- Prominent forehead
- Receding chin
- Tented mouth
- Upward slanting of the opening between the eyelids
- Zygomatic flattening
- Downward slanting of the opening between the eyelids
- Extra teeth
- Failure of development of all teeth
- Failure of development of between one and six teeth
- Failure of development of more than six teeth
- Short neck
- Short philtrum
- Cleft nasal tip
Abnormality of limbs
- Rhizomelic arm shortening
- Short humerus
- Disproportionately short upper portion of limb
- Elbow dislocation
- Short fingers or toes
- Short palm
- Shortened 1st long bone of hand
- Smaller or shorter than typical limbs
Show 14 more traits
- Broad femoral neck
- Curvature of little finger
- Dislocated radial head
- Short calf bone
- Avascular necrosis of the capital femoral epiphysis
- Coxa valga
- Coxa vara
- Dislocated kneecap
- Finger syndactyly
- Hip dislocation
- Permanent flexion of the finger
- Hypoplastic distal humeri
- Limited elbow flexion
- Limited elbow flexion/extension
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). FZD2 gene: frizzled class receptor 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/fzd2
Dante Labs. FZD2 gene: frizzled class receptor 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/fzd2
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