Gene
VPS33A
VPS33A core subunit of CORVET and HOPS complexes
- HGNC 18179(opens in a new tab)
- Ensembl gene ENSG00000139719(opens in a new tab)
- NCBI Gene 65082(opens in a new tab)
Summary
- Cytogenetic location
- 12q24.31
- Coordinates
- Chromosome 12: 122,229,564–122,266,494 (GRCh38)
- Exons
- 13 exons across 36.9 kb
- Protein
- 596 amino acids
- MANE Select transcript
- ENST00000267199.9NM_022916.6
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads VPS33A yet. The test sequences your whole genome, so your data includes it all the same.
How VPS33A is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 4.6 kb of the gene's 36.9 kb; 1,791 of those bases code for the protein.
How a genome test reads VPS33A
1
position in VPS33A where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 36.9 kb of VPS33A, introns included, not only the 4.6 kb of exons.
Traits linked to VPS33A
The Human Phenotype Ontology lists these as features of the rare conditions VPS33A can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Absent speech development
- Global developmental delay
- Motor delay
- Brain degeneration
- Decreased reflex response
- Delayed CNS myelination
- Inability to walk
- Brain imaging abnormality
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). VPS33A gene: VPS33A core subunit of CORVET and HOPS complexes. Retrieved 16 October 2026, from https://dantelabs.com/genes/vps33a
Dante Labs. VPS33A gene: VPS33A core subunit of CORVET and HOPS complexes [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/vps33a
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