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Gene

MID1

midline 1

Summary

Cytogenetic location
Xp22.2
Coordinates
Chromosome X: 10,445,556–10,620,585 (GRCh38)
Exons
10 exons across 175 kb
Protein
667 amino acids
Also known as
OS, FXY, TRIM18, RNF59
MANE Select transcript
ENST00000317552.9NM_000381.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads MID1 yet. The test sequences your whole genome, so your data includes it all the same.

How MID1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome X, with a bracket where MID1 sits. MID1 and 3 genes near it on chromosome X, from 10,033,071 to 11,033,070.Chromosome XXp22.2p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q2810.2 Mb10.4 Mb10.6 Mb10.8 Mb11 MbWWC3: 10,015,254–10,144,592, forward strandWWC3CLCN4: 10,156,938–10,237,663, forward strandCLCN4MID1: 10,445,556–10,620,585, reverse strandMID1: 10,566,888–10,576,955, reverse strandDiagram of MID1: 10 exons on the reverse strand of chromosome XExon 10: 9 known disease-causing sitesExon 9: 4 known disease-causing sitesExon 8: 3 known disease-causing sitesExon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 4 known disease-causing sitesExon 2: 4 known disease-causing sitesExon 10: 10,445,556–10,449,716, 4,161 basesExon 9: 10,454,870–10,455,077, 208 basesExon 8: 10,459,646–10,459,807, 162 basesExon 7: 10,469,697–10,469,840, 144 basesExon 6: 10,474,623–10,474,750, 128 basesExon 5: 10,482,480–10,482,628, 149 basesExon 4: 10,495,584–10,495,691, 108 basesExon 3: 10,523,092–10,523,187, 96 basesExon 2: 10,566,888–10,567,603, 716 basesExon 1: 10,620,290–10,620,585, 296 bases109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.2 kb of the gene's 175 kb; 2,004 of those bases code for the protein.

How a genome test reads MID1

34

positions in MID1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 175 kb of MID1, introns included, not only the 6.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MID1 gene: midline 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/mid1

Vancouver

Dante Labs. MID1 gene: midline 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/mid1

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