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Gene

TSR2

TSR2 ribosome maturation factor

Summary

Cytogenetic location
Xp11.22
Coordinates
Chromosome X: 54,440,404–54,448,032 (GRCh38)
Exons
5 exons across 7.6 kb
Protein
191 amino acids
Also known as
DT1P1A10, RP1-112K5.2, WGG1
MANE Select transcript
ENST00000375151.5NM_058163.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads TSR2 yet. The test sequences your whole genome, so your data includes it all the same.

How TSR2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome X, with a bracket where TSR2 sits. TSR2 and 9 genes near it on chromosome X, from 53,944,218 to 54,944,217.Chromosome XXp11.22p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q2854 Mb54.2 Mb54.4 Mb54.6 Mb54.8 MbPHF8: 53,934,245–54,048,958, reverse strandPHF8FAM120C: 54,068,324–54,183,581, reverse strandFAM120CWNK3: 54,192,823–54,358,642, reverse strandWNK3TSR2: 54,440,404–54,448,032, forward strandTSR2FGD1: 54,445,454–54,496,248, reverse strandFGD1GNL3L: 54,529,900–54,621,565, forward strandGNL3LITIH6: 54,748,918–54,798,255, reverse strandITIH6MAGED2: 54,807,572–54,816,015, forward strandMAGED2TRO: 54,920,462–54,931,436, forward strandTROPFKFB1: 54,931,434–54,994,789, reverse strandPFKFB1Diagram of TSR2: 5 exons on the forward strand of chromosome XExon 3: 1 known disease-causing siteExon 1: 54,440,404–54,440,502, 99 basesExon 2: 54,440,690–54,440,780, 91 basesExon 3: 54,443,400–54,443,491, 92 basesExon 4: 54,444,008–54,444,184, 177 basesExon 5: 54,444,416–54,448,032, 3,617 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.1 kb of the gene's 7.6 kb; 576 of those bases code for the protein.

Sequencing TSR2

2Low

How hard TSR2 is to sequence with short reads, out of 100

  • Mappability0%
  • Homology0%
  • Repeats8.2%
  • GC content8.1%
  • Reference coverage0%

1

position in TSR2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.6 kb of TSR2, introns included, not only the 4.1 kb of exons.

Traits linked to TSR2

The Human Phenotype Ontology lists these as features of the rare conditions TSR2 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). TSR2 gene: TSR2 ribosome maturation factor. Retrieved 17 October 2026, from https://dantelabs.com/genes/tsr2

Vancouver

Dante Labs. TSR2 gene: TSR2 ribosome maturation factor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tsr2

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