Gene
EIF4A2
eukaryotic translation initiation factor 4A2
- HGNC 3284(opens in a new tab)
- Ensembl gene ENSG00000156976(opens in a new tab)
- NCBI Gene 1974(opens in a new tab)
Summary
- Cytogenetic location
- 3q27.3
- Coordinates
- Chromosome 3: 186,783,577–186,789,897 (GRCh38)
- Exons
- 11 exons across 6.3 kb
- Protein
- 407 amino acids
- Also known as
- DDX2B, EIF4A, BM-010
- Previous symbols
- EIF4F
- MANE Select transcript
- ENST00000323963.10NM_001967.4
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads EIF4A2 yet. The test sequences your whole genome, so your data includes it all the same.
How EIF4A2 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 1.9 kb of the gene's 6.3 kb; 1,224 of those bases code for the protein.
How a genome test reads EIF4A2
8
positions in EIF4A2 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 6.3 kb of EIF4A2, introns included, not only the 1.9 kb of exons.
Traits linked to EIF4A2
The Human Phenotype Ontology lists these as features of the rare conditions EIF4A2 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Absent speech development
- Attention deficit
- Atypical absence seizure
- Autism
- Brief seizures with staring spells
- Cerebellar vermis hypoplasia
- Delayed fine motor development
- Delayed motor skills
Show 24 more traits
- Delayed speech and language development
- Diminishment of social interactions
- Epilepsy
- Epileptic spasm
- Fluid-filled sac located in membrane surrounding brain or spinal cord
- Focal emotional seizure with laughing
- Gliosis
- Global developmental delay
- Grand mal seizures
- Head-banging
- Hypoplasia of the pons
- Impulsivity
- Infantile spasms
- Intellectual disability
- Intellectual disability, mild
- Intellectual disability, severe
- Mild global developmental delay
- Myoclonic seizure
- Ongoing loss of nerve cells
- Seizure affecting one half of brain
- Severe global developmental delay
- Short corpus callosum
- Thin corpus callosum
- Ventriculomegaly
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). EIF4A2 gene: eukaryotic translation initiation factor 4A2. Retrieved 17 October 2026, from https://dantelabs.com/genes/eif4a2
Dante Labs. EIF4A2 gene: eukaryotic translation initiation factor 4A2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/eif4a2
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