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Gene

GPC6

glypican 6

Summary

Cytogenetic location
13q31.3-q32.1
Coordinates
Chromosome 13: 93,226,807–94,408,020 (GRCh38)
Exons
9 exons across 1,181.2 kb
Protein
555 amino acids
MANE Select transcript
ENST00000377047.9NM_005708.5
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads GPC6 yet. The test sequences your whole genome, so your data includes it all the same.

How GPC6 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 13, with a bracket where GPC6 sits. GPC6 and 8 genes near it on chromosome 13, from 92,045,593 to 95,589,234.Chromosome 1313q31.3-q32.1p13p12p11.2p11.1q11q12.11q12.12q12.13q12.2q12.3q13.1q13.2q13.3q14.11q14.12q14.13q14.2q14.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q3492.5 Mb93 Mb93.5 Mb94 Mb94.5 Mb95 Mb95.5 MbGPC5: 91,398,585–92,873,682, forward strandGPC5GPC6: 93,226,807–94,408,020, forward strandGPC6DCT: 94,436,811–94,479,682, reverse strandDCTTGDS: 94,574,041–94,596,286, reverse strandTGDSGPR180: 94,601,788–94,653,091, forward strandGPR180SOX21: 94,709,622–94,712,545, reverse strandSOX21ABCC4: 95,019,831–95,301,822, reverse strandABCC4CLDN10: 95,433,594–95,603,306, forward strandCLDN10DZIP1: 95,578,202–95,644,740, reverse strandDZIP1Diagram of GPC6: 9 exons on the forward strand of chromosome 13Exon 3: 1 known disease-causing siteExon 1: 93,226,807–93,227,616, 810 basesExon 2: 93,545,263–93,545,421, 159 basesExon 3: 93,830,154–93,830,545, 392 basesExon 4: 94,027,729–94,027,894, 166 basesExon 5: 94,286,349–94,286,479, 131 basesExon 6: 94,305,980–94,306,123, 144 basesExon 7: 94,382,414–94,382,550, 137 basesExon 8: 94,398,466–94,398,641, 176 basesExon 9: 94,403,015–94,408,020, 5,006 bases1595′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.1 kb of the gene's 1,181.2 kb; 1,668 of those bases code for the protein.

Sequencing GPC6

1

position in GPC6 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 1,181.2 kb of GPC6, introns included, not only the 7.1 kb of exons.

Traits linked to GPC6

The Human Phenotype Ontology lists these as features of the rare conditions GPC6 can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GPC6 gene: glypican 6. Retrieved 17 October 2026, from https://dantelabs.com/genes/gpc6

Vancouver

Dante Labs. GPC6 gene: glypican 6 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/gpc6

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