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Gene

CTNNB1

catenin beta 1

Summary

Cytogenetic location
3p22.1
Coordinates
Chromosome 3: 41,199,505–41,240,443 (GRCh38)
Exons
15 exons across 40.9 kb
Protein
781 amino acids
Also known as
beta-catenin, armadillo
Previous symbols
CTNNB
MANE Select transcript
ENST00000349496.11NM_001904.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Vitreoretinopathy

    • Vitreoretinal Degeneration
      • 2 GenCC submitters rate it definitive or strong

Broader groupings

How CTNNB1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where CTNNB1 sits. CTNNB1 and 1 gene near it on chromosome 3, from 40,719,974 to 41,719,973.Chromosome 33p22.1p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2940.8 Mb41 Mb41.2 Mb41.4 Mb41.6 MbCTNNB1: 41,199,505–41,240,443, forward strandCTNNB1ULK4: 41,246,599–41,962,236, reverse strandULK4Diagram of CTNNB1: 15 exons on the forward strand of chromosome 3Exon 3: 9 known disease-causing sitesExon 4: 8 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 7: 10 known disease-causing sitesExon 8: 3 known disease-causing sitesExon 9: 13 known disease-causing sitesExon 10: 6 known disease-causing sitesExon 11: 5 known disease-causing sitesExon 12: 10 known disease-causing sitesExon 13: 6 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 15: 2 known disease-causing sitesExon 1: 41,199,505–41,199,670, 166 basesExon 2: 41,224,021–41,224,081, 61 basesExon 3: 41,224,526–41,224,753, 228 basesExon 4: 41,224,954–41,225,207, 254 basesExon 5: 41,225,334–41,225,572, 239 basesExon 6: 41,225,660–41,225,861, 202 basesExon 7: 41,227,208–41,227,352, 145 basesExon 8: 41,233,341–41,233,444, 104 basesExon 9: 41,233,529–41,233,867, 339 basesExon 10: 41,234,139–41,234,297, 159 basesExon 11: 41,235,724–41,235,843, 120 basesExon 12: 41,236,349–41,236,499, 151 basesExon 13: 41,236,588–41,236,709, 122 basesExon 14: 41,238,016–41,238,076, 61 basesExon 15: 41,239,134–41,240,443, 1,310 bases12468101214155′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.7 kb of the gene's 40.9 kb; 2,346 of those bases code for the protein.

How a genome test reads CTNNB1

100

positions in CTNNB1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 40.9 kb of CTNNB1, introns included, not only the 3.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CTNNB1 gene: catenin beta 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/ctnnb1

Vancouver

Dante Labs. CTNNB1 gene: catenin beta 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ctnnb1

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