AtlasGene
DVL1
dishevelled segment polarity protein 1
- HGNC 3084↗(opens in a new tab)
- Ensembl gene ENSG00000107404↗(opens in a new tab)
- NCBI Gene 1855↗(opens in a new tab)
Summary
- Cytogenetic location
- 1p36.33
- Coordinates
- Chromosome 1: 1,335,278–1,349,418 (GRCh38)
- Exons
- 15 exons across 14.1 kb
- Protein
- 695 amino acids
- MANE Select transcript
- ENST00000378888.10NM_001330311.2
- Locus type
- Protein-coding
- Very high
- Confident
- Low
- Very low
AtlasThis page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/genes/dvl1.json"
page <- fromJSON(url)
page$gene$nameRead DVL1, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome TestCurated reports relevant to this gene
No Genome Test report reads DVL1 yet. The test sequences your whole genome, so your data includes it all the same.
How DVL1 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 3.3 kb of the gene's 14.1 kb; 2,088 of those bases code for the protein.
Sequencing DVL1
10Moderate
How hard DVL1 is to sequence with short reads, out of 100Each bar is the share of DVL1's exon bases in that kind of difficult region. The score weighs them by how much each costs a short-read call: 0 when no base is in any, 100 when every base is in all of them.
- MappabilityStretches where 100 or 250 bp reads cannot be placed uniquely, so a call there may be missing or wrong. Weight 35%.0%
- HomologySegmental duplications: copies elsewhere in the genome, such as paralogues and pseudogenes, at 90% identity or more. Weight 30%.0%
- RepeatsTandem repeats and runs of one base, which reads slip on and may not span. Weight 15%.4%
- GC contentWindows under 25% or over 65% G and C, which library preparation covers thinly. Weight 10%.92%
- Reference coverageGaps in the reference assembly nearby, where there is no sequence for reads to align to. Weight 10%.0%
15
positions in DVL1 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 14.1 kb of DVL1, introns included, not only the 3.3 kb of exons.
Traits linked to DVL1
The Human Phenotype Ontology lists these as features of the rare conditions DVL1 can cause. Each trait's page lists the other genes linked to it.
Abnormality of head or neck
- Big calvaria
- Calvarial osteosclerosis
- Depressed nasal bridge
- Failure of development of more than six teeth
- Frontal bossing
- Full upper lip
- High forehead
- High palate
Show 48 more traits
- Midface retrusion
- Short nose
- Triangular mouth
- Wide mouth
- Wide nasal bridge
- Gum enlargement
- Long philtrum
- Nasal tip, upturned
- Wide nose
- Abnormality of the gums
- Broad opening between the eyelids
- Central cleft palate
- Cleft palate
- Cleft tongue
- Curly eyelashes
- Delayed loss of baby teeth
- Downturned corners of mouth
- Downward slanting of the opening between the eyelids
- Euryblepharon
- Eye folds
- Flat face
- High, narrow palate
- Increased thickness of skull cap
- Little lower jaw
- Long eyelashes
- Open bite
- Prominent forehead
- Receding chin
- Short lingual frenulum
- Thin red part of the upper lip
- Upward slanting of the opening between the eyelids
- Wider-than-typical soft spot of skull
- Zygomatic flattening
- Absent uvula
- Cleft soft palate
- Extra teeth
- Failure of development of all teeth
- Failure of development of between one and six teeth
- Short neck
- Short philtrum
- Abnormal dentition
- Abnormally large tongue
- Bad bite
- Cleft of the mouth
- Delayed eruption of teeth
- Dental crowding
- Narrow palate
- Short hard palate
Abnormality of limbs
- Hip dislocation
- Short fingers or toes
- Underdeveloped outer large forearm bone
- Broad big toe
- Curvature of digit
- Short palm
- Smaller or shorter than typical limbs
- Broad thumb
Show 21 more traits
- Curvature of little finger
- Dislocated radial head
- Disproportionately short middle portion of limb
- Limited elbow extension and supination
- Notched outermost bone of the thumb
- Partial duplication of hand bones
- Partial duplication of the thumb bones
- Avascular necrosis of the capital femoral epiphysis
- Coxa valga
- Coxa vara
- Elbow dislocation
- Finger syndactyly
- Permanent flexion of the finger
- Broad toe
- Disproportionately short upper portion of limb
- Duplication of the outermost bone of hand
- Notched outermost bones of toes
- Radial deviation of finger
- Short middle bone of the little finger
- Short outermost finger bone
- Small hand
Abnormality of the musculoskeletal system
- Limited hip extension
- Short long bone
- Abnormal vertebral body morphology
- Funnel chest
- Kyphoscoliosis
- Missing part of vertebrae
- Permanent flexion of the finger or toe
- Scoliosis
Show 3 more traits
Abnormality of the genitourinary system
- Short penis
- Underdeveloped penis
- Undescended testes
- Hypospadias
- Small clitoris
- Small labia majora
- Underdeveloped inner lips
- Abnormality of the penis
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.18-e609d43e.
Cite this page
Dante Labs. (n.d.). DVL1 gene: dishevelled segment polarity protein 1. Retrieved 18 October 2026, from https://dantelabs.com/genes/dvl1
Dante Labs. DVL1 gene: dishevelled segment polarity protein 1 [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/dvl1
AtlasOne test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks